The ADP/ATP translocase drives mitophagy independent of nucleotide exchange
Open accessAbstract
Mitochondrial homeostasis depends on mitophagy, the programmed degradation of mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a multidimensional CRISPR-Cas9 genetic screen, using multiple mitophagy reporter systems and pro-mitophagy triggers, and identify numerous components of parkin-dependent mitophagy 1. Unexpectedly, we find that the adenine nucleotide translocator (ANT) complex is required for mitophagy in several cell types. Whereas pharmacological inhibition of ANT-mediated ADP/ATP exchange promotes mitophagy, genetic ablation of ANT paradoxically suppresses mitophagy. Notably, ANT promotes mitophagy independently of its nucleotide translocase catalytic activity. Instead, the ANT complex is required for inhibition of the presequence translocase TIM23, which leads to stabilization of PINK1, in response to bioenergetic collapse. ANT modulates TIM23 indirectly via interaction with TIM44, which regulates peptide import through TIM23 2. Mice that lack ANT1 show blunted mitophagy and consequent profound accumulation of aberrant mitochondria. Disease-causing human mutations in ANT1 abrogate binding to TIM44 and TIM23 and inhibit mitophagy. Together, our findings show that ANT is an essential and fundamental mediator of mitophagy in health and disease.
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Multiple genome-wide siRNA/CRISPR-Cas9 screens have identified mitophagy genes with little overlap between studies.
“Multiple genome-wide siRNA/CRISPR-Cas9 screens have already identified mitophagy genes although with little overlap between studies [15–18].”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [18]
The paper reports its own genome-wide CRISPR/Cas9 mitophagy screen (Abstract; page unavailable) and cites an earlier genome-wide RNAi screen (References; page unavailable). It reports variability among assays within its own study, but does not establish that different studies identified genes with little overlap. (LLM, conf=0.86)
Experimental — accuracy not yet measuredATG9A was previously identified as a regulator of PINK1-PRKN induced mitophagy in a CRISPR screen.
“It was also previously identified as a regulator of PINK1-PRKN induced mitophagy in a CRISPR screen [18]”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [18]
The paper describes a CRISPR screen for PINK1–Parkin-mediated mitophagy and says it identified autophagosome-related genes (main text and Extended Data Figures 1–2; pages unavailable). Searches for “ATG9A” and “Atg9 mitophagy CRISPR screen” found no passage identifying ATG9A as a screen hit, so our copy does not verify the specific claim. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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- Authors
- Hoshino, A., Wang, W.-J., Wada, S., McDermott-Roe, C., Evans, C. S., Gosis, B., Morley, M. P., Rathi, K. S., Li, J., Li, K., Yang, S., McManus, M. J., Bowman, C., Potluri, P., Levin, M., Damrauer, S., Wallace, D. C., Holzbaur, E. L. F., & Arany, Z.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Arany, Zoltan
- ORCID
- Venue
- Nature
- Published
- 2019-10-16
- Volume
- 575
- Issue
- 7782
- Pages
- 375-379
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC6858570
- OpenAlex
- W2980489405
- Cited by
- 228
- References
- 44
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 39 · 2023: 27 · 2022: 44 · 2021: 43 · 2020: 29
- FWCI
- 22.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (R01OD010944)
- Japan Society for the Promotion of Science (19H03658)
- National Heart, Lung, and Blood Institute (R01HL094499, R01HL126797, T32HL007843)
- National Institute of Mental Health (R01MH110185, R01MH108592)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107667, R01DK114103)
- National Institute of Neurological Disorders and Stroke (R37NS060698, R01NS021328)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- mitophagy, adenine nucleotide translocase, ANT1, Tim23, Tim44, mitochondrial homeostasis, nucleotide exchange
- MeSH terms
- Mitochondrial Precursor Protein Import Complex Proteins, PTEN-Induced Putative Kinase, Animals, Cell Line, Nucleotides, Protein Binding, Protein Kinases, Mitochondrial Membrane Transport Proteins, Mice, Mitophagy
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