BRCA1-A and BRISC: multifunctional molecular machines for ubiquitin signaling

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A pathology atlas of the human cancer transcriptome

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Defining the Human Deubiquitinating Enzyme Interaction Landscape

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Interferon-Stimulated Genes: What Do They All Do?

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Mechanisms of Deubiquitinase Specificity and Regulation

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The BRCT Domain Is a Phospho-Protein Binding Domain

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The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

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Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

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RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

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RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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Ubiquitin-binding domains

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Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

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Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

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Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

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DNA double-strand break repair pathway choice and cancer

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Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

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Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

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Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

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DNA DSB repair pathway choice: an orchestrated handover mechanism

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Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

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Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

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Endocytosis: the DUB version

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Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment

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Common variants at 19p13 are associated with susceptibility to ovarian cancer

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Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

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Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

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Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

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Crystal structure of the human COP9 signalosome

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Structural basis for regulation of human acetyl-CoA carboxylase

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K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

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Structural basis for specific recognition of Lys 63‐linked polyubiquitin chains by tandem UIMs of RAP80

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SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

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Ubiquitin chain conformation regulates recognition and activity of interacting proteins

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RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

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Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

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MERIT40 facilitates BRCA1 localization and DNA damage repairPreprint

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Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation

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MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaksPreprint

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The BRCA1 C-terminal domain: structure and function

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Assembly, analysis and architecture of atypical ubiquitin chains

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Phosphorylation and Specific Ubiquitin Acceptor Sites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor

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Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis

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Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

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Loss of BRCC3 Deubiquitinating Enzyme Leads to Abnormal Angiogenesis and Is Associated with Syndromic Moyamoya

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The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity

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The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments

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Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

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Structural Basis for Cell Cycle Checkpoint Control by the BRCA1−CtIP Complex,

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How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

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A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses

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Mechanisms of regulation and diversification of deubiquitylating enzyme function

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Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex

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Metabolic control of BRISC-SHMT2 assembly regulates immune signalling

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Structural basis of BRCC36 function in DNA repair and immune regulation

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Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

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Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy

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Mammalian Casein Kinase 1α and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling

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Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

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Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates

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NBA1/MERIT40 and BRE Interaction Is Required for the Integrity of Two Distinct Deubiquitinating Enzyme BRCC36-containing Complexes

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Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability

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Higher-Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

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Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys63-linked Polyubiquitin

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Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

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Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

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Breast Cancer–Associated <i>Abraxas</i> Mutation Disrupts Nuclear Localization and DNA Damage Response Functions

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Structural Evidence for Direct Interactions between the BRCT Domains of Human BRCA1 and a Phospho-peptide from Human ACC1

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Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins

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The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells

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The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair

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