Cited by 347DNA Repair MechanismsPARP inhibition in cancer therapyBRCA gene mutations in cancer

DNA double-strand break repair pathway choice and cancer

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Aparicio, Tomas, Baer, Richard, Gautier, Jean·2014·DNA Repair

Abstract

Since DNA double-strand breaks (DSBs) contribute to the genomic instability that drives cancer development, DSB repair pathways serve as important mechanisms for tumor suppression. Thus, genetic lesions, such as BRCA1 and BRCA2 mutations, that disrupt DSB repair are often associated with cancer susceptibility. In addition, recent evidence suggests that DSB "mis-repair", in which DSBs are resolved by an inappropriate repair pathway, can also promote genomic instability and presumably tumorigenesis. This notion has gained currency from recent cancer genome sequencing studies which have uncovered numerous chromosomal rearrangements harboring pathological DNA repair signatures. In this perspective, we discuss the factors that regulate DSB repair pathway choice and their consequences for genome stability and cancer.

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Authors
Aparicio, T., Baer, R., & Gautier, J.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
Gautier, Jean
Venue
DNA Repair
Publisher
Elsevier BV
Published
2014-07
Volume
19
Pages
169-175
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2090854519
Cited by
347
References
97
Citations by year
2026: 13 · 2025: 20 · 2024: 27 · 2023: 22 · 2022: 40 · 2021: 36 · 2020: 34 · 2019: 33 · 2018: 39 · 2017: 22 · 2016: 31 · 2015: 26 · 2014: 4
FWCI
11.35
Type
journal article
Language
en
Open access
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (P01CA174653, R01CA092245, R01CA167826)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Keywords
DNA double-strand break repair, repair pathway choice, genomic instability, cancer susceptibility, BRCA1, BRCA2, chromosomal rearrangements, tumor suppression, carcinogenesis
MeSH terms
Tumor Suppressor p53-Binding Protein 1, DNA Repair, Humans, Neoplasms, Recombination, Genetic, Signal Transduction, BRCA1 Protein, Genomic Instability, Intracellular Signaling Peptides and Proteins, DNA Breaks, Double-Stranded, DNA End-Joining Repair, Carcinogenesis

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