Cited by 1,095Advanced Glycation End Products researchPotato Plant ResearchChronic Kidney Disease and Diabetes

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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

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Nowotny, Kerstin, Jung, Tobias, Höhn, Annika, Weber, Daniela, Grune, Tilman·2015·Biomolecules

DOI 10.3390/biom5010194PMC PMC4384119

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Abstract

Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease characterized by insulin resistance and β cell failure leading to elevated blood glucose levels. Hyperglycemia is suggested to be the main cause of diabetic complications, which not only decrease life quality and expectancy, but are also becoming a problem regarding the financial burden for health care systems. Therefore, and to counteract the continually increasing prevalence of diabetes, understanding the pathogenesis, the main risk factors, and the underlying molecular mechanisms may establish a basis for prevention and therapy. In this regard, research was performed revealing further evidence that oxidative stress has an important role in hyperglycemia-induced tissue injury as well as in early events relevant for the development of T2DM. The formation of advanced glycation end products (AGEs), a group of modified proteins and/or lipids with damaging potential, is one contributing factor. On the one hand it has been reported that AGEs increase reactive oxygen species formation and impair antioxidant systems, on the other hand the formation of some AGEs is induced per se under oxidative conditions. Thus, AGEs contribute at least partly to chronic stress conditions in diabetes. As AGEs are not only formed endogenously, but also derive from exogenous sources, i.e., food, they have been assumed as risk factors for T2DM. However, the role of AGEs in the pathogenesis of T2DM and diabetic complications—if they are causal or simply an effect—is only partly understood. This review will highlight the involvement of AGEs in the development and progression of T2DM and their role in diabetic complications.

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Authors: Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T.
Affiliations: German Institute of Human Nutrition (DE)
Corresponding author: Grune, Tilman
ORCID: Jung, Tobias
Höhn, Annika
Weber, Daniela
Grune, Tilman
Venue: Biomolecules
Publisher: MDPI AG
Published: 2015-03-16
Volume: 5
Issue: 1
Pages: 194-222
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom5010194
PMC: PMC4384119
OpenAlex: W1986014108
Cited by: 1,095
References: 172
Citations by year: 2026: 59 · 2025: 93 · 2024: 106 · 2023: 138 · 2022: 132 · 2021: 118 · 2020: 106 · 2019: 99 · 2018: 99 · 2017: 68 · 2016: 61 · 2015: 14
FWCI: 8.00
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: advanced glycation end products, oxidative stress, type 2 diabetes, hyperglycemia, reactive oxygen species, antioxidant defense, diabetes complications, insulin resistance, beta-cell failure
MeSH terms: Animals, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Cell Death, Glycation End Products, Advanced, Oxidative Stress, Insulin-Secreting Cells

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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

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