Cited by 191Curcumin's Biomedical ApplicationsDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

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Formulations of Curcumin Nanoparticles for Brain Diseases

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Del Prado-Audelo, María L., Caballero-Florán, Isaac H., Meza-Toledo, Jorge A., Mendoza-Muñoz, Néstor, González-Torres, Maykel, Florán, Benjamín, Cortés, Hernán, Leyva-Gómez, Gerardo·2019·Biomolecules

DOI 10.3390/biom9020056PMC PMC6406762

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Abstract

Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms “curcumin” and “curcumin brain diseases”, which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.

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Authors: Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G.
Affiliations: Laboratorio de Posgrado en Tecnología Farmacéutica, FES-Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54740, Mexico
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Universidad del Valle de México (MX)
Facultad de Ciencias Químicas, Universidad de Colima, C.P. Colima 28400, México
CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico
Departamento de Fisiología, Biofísica & Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico
Instituto Nacional de Rehabilitación (MX)
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, C.P. Ciudad de México 04510, Mexico
Corresponding author: Cortés, Hernán
ORCID: Caballero-Florán, Isaac H.
Mendoza-Muñoz, Néstor
González-Torres, Maykel
Florán, Benjamín
Cortés, Hernán
Venue: Biomolecules
Publisher: MDPI AG
Published: 2019-02-08
Volume: 9
Issue: 2
Pages: 56
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom9020056
PMC: PMC6406762
OpenAlex: W2913877945
Cited by: 191
References: 129
Citations by year: 2026: 18 · 2025: 28 · 2024: 22 · 2023: 30 · 2022: 26 · 2021: 35 · 2020: 21 · 2019: 11
FWCI: 1.54
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (PAPIIT TA 200318)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: curcumin, curcumin nanoparticles, brain disorders, nanoparticle drug delivery, bioavailability, water solubility, anti-inflammatory activity, antioxidant activity, polyphenols, neurodegenerative diseases
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Brain Diseases, Curcumin, Humans, Temperature, Molecular Structure, Curcuma, Nanoparticles

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