Cited by 191Curcumin's Biomedical ApplicationsDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

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Formulations of Curcumin Nanoparticles for Brain Diseases

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Del Prado-Audelo, María L., Caballero-Florán, Isaac H., Meza-Toledo, Jorge A., Mendoza-Muñoz, Néstor, González-Torres, Maykel, Florán, Benjamín, Cortés, Hernán, Leyva-Gómez, Gerardo·2019·Biomolecules

DOI 10.3390/biom9020056PMC PMC6406762

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Abstract

Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms “curcumin” and “curcumin brain diseases”, which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.

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Figure 1 Chemical structure of curcumin and keto–enol tautomerism.CC BY · PubMed Central

Figure 2 Thermal analysis of curcumin. Thermogravimetric analysis ((a), green line) and differential scanning calorimetry ((b), blue line). Melting point of curcumin is indicated at 174.05 °C.CC BY · PubMed Central

Figure 3 Curcumin dissolved in different mediums. (A) Curcumin in an acidic solution (pH 3.5); and (B) curcumin in a neutral solution (pH 7.4); both with the addition of 1% Tween 80 in order to increase solubility. (C) Curcumin in a basic solution (pH 12).CC BY · PubMed Central

Figure 4 Ultraviolet-Visible spectrophotometric scanning of curcumin. (a) Absorption in methanol, maximum peak of absorption found at 420 nm; (b) Absorption in neutral medium, maximum peak of absorption found at 420 nm; and (c) Absorption in basic medium, maximum peak of absorption found at 470 nm.CC BY · PubMed Central

Figure 5 Fourier transform infrared spectroscopy of curcumin. Characteristic bands of the molecule are indicated with arrows.CC BY · PubMed Central

Figure 6 Potential applications of curcumin. Due to the structure of curcumin, this molecule could be applied as treatment for a wide range of disorders, such as chronic diseases, inflammatory disorders, infections of diverse etiology, and other conditions. Adapted with permission from [26]. 2007, Springer Nature.CC BY · PubMed Central

Figure 7 Curcumin is a pleiotropic agent with multiple molecular targets. This molecule could modify the expression of genes, inflammatory cytokines, transcriptional and growth factors, enzymes, and receptors, among others. Adapted with permission from [26]. 2007, Springer Nature.CC BY · PubMed Central

Figure 8 Signaling pathways modulated by curcumin. Up and green arrows indicate the intermediaries upregulated by curcumin; meanwhile, down and red arrows indicate the intermediaries downregulated by curcumin. Adapted with permission from [26]. 2007, Springer Nature.CC BY · PubMed Central

Figure 9 Antioxidant mechanism of curcumin. There are two mechanisms to form phenoxyl radicals. The first mechanism (A) begins by initial electron transfer to the free radical; thus, a radical cation is formed, which produces a phenoxyl radical by a proton loss. The second mechanism (B) is related to direct hydrogen abstraction. Based on the bond dissociation energies, many authors suggest that the most susceptible target for free radicals in curcumin is phenolic OH.CC BY · PubMed Central

Figure 10 Curcumin solubility: (A) Curcumin showed poor solubility in aqueous medium; (B) the use of the nanoplatforms increased the drug solubility. Curcumin was entrapped in poly-ε-caprolactone nanoparticles stabilized by Pluronic F68 (Thermofisher, Whaltam, USA), with size of 170 nm and zeta potential of −7 mV.CC BY · PubMed Central

Figure 11 Atomic force microscopy (AFM) microscopy of curcumin poly-ε-caprolactone nanoparticles in two magnifications, left and right. Images in AFM (A), 2D (B) and 3D (C) mode.CC BY · PubMed Central

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Kakkar, V., & Kaur, I. P. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.08.006 · Cited by 217 · cited 1×
“3 Aluminum-induced behavioral (in vivo model) [90]”
Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
Yin, H., Guo, Q., Li, X., Tang, T., Li, C., Wang, H., Sun, Y., Feng, Q., Ma, C., Gao, C., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701495 · Cited by 214 · cited 6×
“Some authors have reported that curcumin suppresses the expression of IL-1β [44,45].”
BackgroundInfluential
Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation
Malvajerd, S. S., Azadi, A., Izadi, Z., Kurd, M., Dara, T., Dibaei, M., Zadeh, M. S., Javar, H. A., & Hamidi, M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00510 · Cited by 211 · cited 2×
“It has been suggested that aluminum is involved in the etiology of AD; thus, in an early study, the neuroprotective effect of solid lipid nanoparticles loaded with curcumin (SLN-Cur) was proved in an AD mouse model induced by 100 mg/kg of aluminum chloride [91].”
Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery
Nasr, M. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1092619 · Cited by 208 · cited 1×
“8 Biodistribution (ex vivo and in vivo models) [117]”
Background
Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations
Ramalingam, P., & Ko, Y. T. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1469-1 · Cited by 206 · cited 1×
“7 93, 4 Biodistribution (in vitro and in vivo models) [89]”
Background
Curcumin nanoparticles attenuate neurochemical and neurobehavioral deficits in experimental model of huntington’s disease.
Sandhir, R., Yadav, A., Mehrotra, A., Sunkaria, A., Singh, A., & Sharma, S. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8261-y · Cited by 204 · cited 2×
“[87] fabricated solid lipid nanoparticles loaded with curcumin (SLNP-Cur) and explored their neuroprotective effectiveness in a HD rat model induced by 3-nitropropionic acid (3-NP).”
Background
Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein
Zhang, C. M., Browne, A., Child, D. D., & Tanzi, R. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133520 · Cited by 191 · cited 3×
“Furthermore, it h s been recently de onstrated that curcumin may inhibit protein aggregation, such as amyloid-β (Aβ) protein, which is related to sever l neurological pathologies, such as Alzheimer’s disease (AD) [7].”
BackgroundInfluential
Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi, B., Belletti, D., Pederzoli, F., Masoni, M., Keller, J., Ballestrazzi, A., Vandelli, M. A., Tosi, G., & Grabrucker, A. M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.015 · Cited by 184 · cited 1×
“[129] designed and engineered a curcumin-encapsulated PLGA nanoparticle bound to peptide g7 (Cur-NP-g7) to promote BBB crossing.”
Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats
González-Reyes, S., Guzmán‐Beltrán, S., Medina‐Campos, O. N., & Pedraza‐Chaverrí, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/801418 · Cited by 180 · cited 1×
“[61] evaluated the neuroprotection of curcumin in the primary cultures of the cerebellar granule neurons of rats.”
Background
Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy
Zhang, N., Yan, F., Liang, X., Wu, M., Shen, Y., Chen, M., Xu, Y., Zou, G., Jiang, P., Tang, C., et al. (2018) · Theranostics · doi:10.7150/thno.23734 · Cited by 180 · cited 1×
“[133] developed curcumin-loaded polysorbate 80-modified cerasomes (PS80-NP-Cur).”
A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease
Meng, F., Asghar, S., Gao, S., Su, Z., Song, J., Huo, M., Meng, W., Ping, Q., & Xiao, Y. (2015) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2015.06.025 · Cited by 176 · cited 4×
“60 Alzheimer ́s disease (in vitro and in vivo models) [94]”
BackgroundInfluential
PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice
Huang, N., Lü, S., Liu, X., Zhu, J., Wang, Y., & Liu, R. (2017) · Oncotarget · doi:10.18632/oncotarget.20944 · Cited by 176 · cited 1×
“[130], PLGA nanoparticles were designed conjugated with the S1 peptide (an inhibitor of Aβ generation), brain-targeting calreticulin (CRT) (a peptide that binds to the transferrin receptor), and curcumin (as a therapeutic substance to tackle the disorder).”
Background
Structure-Thermodynamics-Antioxidant Activity Relationships of Selected Natural Phenolic Acids and Derivatives: An Experimental and Theoretical Evaluation
Chen, Y., Xiao, H., Zheng, J., & Liang, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121276 · Cited by 172 · cited 1×
“In addition to BDE and IP, proton dissociation enthalpy, proton affinity (PA), and electron transfer enthalpy are important factors for evaluating antioxidant activity [55,57].”
Background
Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood–Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson’s Disease
Kundu, P., Das, M., Tripathy, K., & Sahoo, S. K. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00207 · Cited by 166 · cited 2×
“[88] designed glyceryl monooleate nanoparticles loaded with piperine and curcumin (GMO-NP-Pip/Cur).”
Background
Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress
Zhang, Z., Jiang, M., Fang, J., Yang, M., Zhang, S., Yin, Y., Li, D., Mao, L., Fu, X., Hou, Y., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9635-y · Cited by 165 · cited 1×
“3 Subarachnoid hemorrhage-induced BBB disruption (in vivo model) [112]”
Background
Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway
Shao-Ling, W. A. N. G., Ying, L. I., Wen, Y., Yan-Feng, C. H. E. N., Na, L.-X., Li, S., & Sun, C. (2009) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(09)60019-2 · Cited by 163 · cited 1×
“[4] found inhibition in the expression of this factor through downregulating the expression of NF-κB.”
Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease
Yanagisawa, D., Shirai, N., Amatsubo, T., Taguchi, H., Hirao, K., Urushitani, M., Morikawa, S., Inubushi, T., Kato, M. G., Kato, F., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.142 · Cited by 157 · cited 1×
“[13]; these authors suggested that curcumin and its analogues exist predominantly in the enol form during binding to Aβ fibrils/aggregates, in turn suggesting that the enolization of curcumin derivatives is crucial for binding to Aβ aggregates in the treatment of AD.”
Background
Curcumin encapsulated in chitosan nanoparticles: A novel strategy for the treatment of arsenic toxicity
Yadav, A., Lomash, V., Samim, M., & Flora, S. J. S. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.05.011 · Cited by 156 · cited 1×
“8 Arsenic toxicity (in vivo model) [102]”
Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin
Grießer, M., Pistis, V., Suzuki, T., Tejera, N., Pratt, D. A., & Schneider, C. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178806 · Cited by 154 · cited 2×
“However, new evidence suggests that the major degradation product is bicyclopentadione, which is the result of the autoxidation of curcumin [24], and is formed by the oxygenation and double cyclization of the heptadienedione chain connecting the two methoxyphenol rings of curcumin [25].”
Background
ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900306x · Cited by 150 · cited 1×
“44 Beta amyloid induced cytotoxicity in neuroblastoma cells (in vitro model) [97]”
Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
Ray, B., & Lahiri, D. K. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.012 · Cited by 150 · cited 3×
“Other molecular targets inhibited by curcumin are inducible nitric oxide synthase (iNOs), c-Jun N-terminal kinase (JNK) activation, and activating protein-1 (AP-1) [28].”
BackgroundInfluential
Curcumin-conjugated Nanoliposomes with High Affinity for Aβ Deposits: Possible Applications to Alzheimer Disease
Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., Antimisiaris, S. G., & Duyckaerts, C. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.004 · Cited by 149 · cited 1×
“5 Amyloid peptide plaques (in vivo model) [124]”
Background
Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability
Wu, X., Xu, J., Huang, X., & Wen, C. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.489560 · Cited by 137
Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells
Sadeghizadeh, M., Birgani, M. T., Isacchi, Marra, F., Bilia, A. R., Mowla, S. J., Najafi, F., & Babaei, E. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s48136 · Cited by 137 · cited 1×
“4, Ψ = −7 EE = 87 Glioblastoma cells (in vitro model) [115]”
Curcumin binds to the α‐helical intermediate and to the amyloid form of prion protein – a new mechanism for the inhibition of PrPSc accumulation
Hafner‐Bratkovič, I., Gašperšič, J., Šmid, L. M., Bresjanac, M., & Jerala, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05105.x · Cited by 127 · cited 1×
“[32] reported that the binding of curcumin to the α-intermediate could block conformational change into the β-structure, and that the binding of curcumin to prion fibrils could prevent further growth, thus, the formation of new seeds.”
Background
Curcumin is a potent modulator of microglial gene expression and migration
Karlstetter, M., der Lippe, E., Walczak, Y., Moehle, C., Aslanidis, A., Mirza, M., & Langmann, T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-125 · Cited by 127 · cited 2×
“It has been demonstrated that curcumin reduces the expression of several inflammatory cytokines, including IL-1α, IL-1β, IL-6, TNF, IFNγ, and many others (Figure 8) [42,43].”
Background
Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity
Bollimpelli, V. S., Kumar, P., Kumari, S., & Kondapi, A. K. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.01.006 · Cited by 121 · cited 1×
“[132] elaborated lactoferrin nanoparticles by sol-oil chemistry, which were loaded with curcumin (Lf-NP-Cur).”
Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin
Chuah, A. M., Jacob, B., Zhang, J., Ramesh, S., Mandal, S., Puthan, J. K., Deshpande, P., Vaidyanathan, V. V., Gelling, R. W., Patel, G. K., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.01.108 · Cited by 120 · cited 1×
“In other studies, curcumin revealed an increase of >1000 times when it was formulated as ASD in hydroxypropyl methylcellulose matrixes [67].”
Background
Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin
Caughey, B. W., Raymond, L. D., Raymond, G. J., Maxson, L., Silveira, J. R., & Baron, G. S. (2003) · Journal of Virology · doi:10.1128/jvi.77.9.5499-5502.2003 · Cited by 119 · cited 1×
“[33] concluded in their work that curcumin inhibits prion protein resistance (PrP-Res) accumulation in neuroblastoma cells infected with the scrapie agent.”
Background
Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells
Liu, Y., Gao, S., Asghar, S., Liu, G., Song, J., Wang, X., Ping, Q. N., Zhang, C., & Xiao, Y. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.10.039 · Cited by 116
Theoretical study on Curcumin: A comparison of calculated spectroscopic properties with NMR, UV–vis and IR experimental data
Benassi, R., Ferrari, É., Lazzari, S., Spagnolo, F., & Saladini, M. (2008) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2008.05.024 · Cited by 112 · cited 2×
“The C=O t t i i ration of t e carboxylic groups (methyl esters and triglycerides) can be attributed to the strong and at 1510 cm−1 [18].”
Background
Bioavailability of curcumin and curcumin glucuronide in the central nervous system of mice after oral delivery of nano-curcumin
Szymusiak, M., Hu, X., León-Plata, P., Ciupinski, P., Wang, Z. J., & Liu, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.07.027 · Cited by 109 · cited 1×
“3 Bioavailability in the CNS (in vivo model) [99]”
Background
Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy
Hashemian, M., Anissian, D., Ghasemi‐Kasman, M., Akbari, A., Khalili-Fomeshi, M., Ghasemi, S., Ahmadi, F., Moghadamnia, A. A., & Ebrahimpour, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.025 · Cited by 106 · cited 1×
“Chitosan-alginate 50 Epilepsy (in vivo model) [103]”
Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease
Yang, R., Zheng, Y., Wang, Q., & Zhao, L. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2759-z · Cited by 99
A cost-effective method to prepare curcumin nanosuspensions with enhanced oral bioavailability
Wang, Y., Wang, C., Zhao, J., Ding, Y., & Li, L. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.09.003 · Cited by 97 · cited 1×
“[68] found an increase in the oral bioavailability of curcumin of about three to four times after the administration of curcumin in nanosuspensions in rats.”
Curcumin-lipoic acid conjugate as a promising anticancer agent on the surface of gold‑iron oxide nanocomposites: A pH-sensitive targeted drug delivery system for brain cancer theranostics
Ghorbani, M., Bigdeli, B., Jalili‐Baleh, L., Baharifar, H., Akrami, M., Dehghani, S., Goliaei, B., Amani, A., Lotfabadi, A., Rashedi, H., et al. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.12.008 · Cited by 96
PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier
Li, J., & Sabliov, C. M. (2013) · Nanotechnology Reviews · doi:10.1515/ntrev-2012-0084 · Cited by 90
Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model
Orunoğlu, M., Kaffashi, A., Pehlivan, S. B., Şahin, S., Söylemezoğlu, F., Oğuz, K. K., & Mut, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.292 · Cited by 87 · cited 1×
“22 EE = 35 Glioblastoma (in vitro and in vivo models) [111]”
Background
Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression
Tizabi, Y., Hurley, L. L., Qualls, Z., & Akinfiresoye, L. R. (2014) · Molecules · doi:10.3390/molecules191220864 · Cited by 84 · cited 2×
“It has been demonstrated that curcumin reduces the expression of several inflammatory cytokines, including IL-1α, IL-1β, IL-6, TNF, IFNγ, and many others (Figure 8) [42,43].”
Background
Curcumin inhibits interferon-γ signaling in colonic epithelial cells
Midura‐Kiela, M. T., Radhakrishnan, V. M., Larmonier, C. B., Laubitz, D., Ghishan, F. K., & Kiela, P. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00275.2011 · Cited by 77 · cited 1×
“[53] studied the interaction of IFN-γ and curcumin in epithelial cells.”
Background
Synthesis of Alginate-Curcumin Nanocomposite and Its Protective Role in TransgenicDrosophilaModel of Parkinson’s Disease
Siddique, Y. H., Khan, W., Singh, B. R., & Naqvi, A. H. (2013) · ISRN Pharmacology · doi:10.1155/2013/794582 · Cited by 77 · cited 1×
“Therefore, this report provided a rationale for employing curcumin-encapsulated nanoparticles in preclinical and clinical studies [131].”
Background
Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells
Kumar, A., Ahuja, A., Ali, J., & Baboota, S. (2016) · Drug Delivery · doi:10.3109/10717544.2014.909906 · Cited by 76 · cited 1×
“137, Ψ = −37 Malignant glioma cells (in vitro model) [116]”
Background
Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection
Howe, C. L., LaFrance‐Corey, R. G., Goddery, E. N., Johnson, R. K., & Mirchia, K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1015-2 · Cited by 76 · cited 1×
“Similarly, the suppression of CCL2 function may decrease the attraction of cells of the immune system to the sites of inflammation, which could result in a slowdown of the advancement of inflammation [50].”
Background
Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition
Paka, G. D., Doggui, S., Zaghmi, A., Safar, R., Dao, L. H., Reisch, A., Klymchenko, A. S., Roullin, G., Joubert, O., & Ramassamy, C. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00611 · Cited by 74 · cited 1×
“[128] evaluated the antioxidant and anti-inflammatory activities of curcumin-loaded PLGA nanoparticles (Cur–PLGA–NP) in SK-N-SH cells, which are human neuroblastoma-derived cells.”
Background
In vitro characterization and in vivo evaluation of nanostructured lipid curcumin carriers for intragastric administration
Fang, M., Jin, J., Bao, Gao, Xu, Wang, Wang, YAO, Y., & Liu (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36257 · Cited by 73 · cited 1×
“21 Pharmacokinetic and biodistribution (in vivo model) [93]”
Background
Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
He, X., Zhu, Y., Wang, M., Jing, G., Zhu, R., & Wang, S. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s109088 · Cited by 72 · cited 1×
“61 Major depression (in vitro and in vivo models) [85]”
Background
Dual‐Targeting Lactoferrin‐Conjugated Polymerized Magnetic Polydiacetylene‐Assembled Nanocarriers with Self‐Responsive Fluorescence/Magnetic Resonance Imaging for In Vivo Brain Tumor Therapy
Fang, J., Chiu, T., Huang, W., Lai, Y., Hu, S., Chen, Y., & Chen, S. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201500750 · Cited by 68 · cited 1×
“3 Orthotopic Brain Tumor-Bearing Rat (in vitro and in vivo models) [123]”
Background
Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates
Mithu, V. S., Sarkar, B., Bhowmik, D., Das, A. K., Chandrakesan, M., Maiti, S., & Madhu, P. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.519447 · Cited by 67 · cited 1×
“[36] reported that curcumin disorganizes Aβ fibrils; the disruption of Aβ-fibrils was achieved by means of structural changes in the salt bridge region and near the C terminus.”
Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm
Alisi, I. O., Uzairu, A., Abechi, S. E., & Idris, S. O. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.03.003 · Cited by 67
Hansen solubility parameters (HSP) for prescreening formulation of solid lipid nanoparticles (SLN): in vitro testing of curcumin-loaded SLN in MCF-7 and BT-474 cell lines
Doktorovová, S., Souto, E. B., & Silva, A. M. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1384491 · Cited by 61
Enhanced solubility and dissolution of curcumin by a hydrophilic polymer solid dispersion and its insilico molecular modeling studies
Gangurde, A. B., Kundaikar, H., Javeer, S. D., Jaiswar, D. R., Degani, M. S., & Amin, P. D. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.08.005 · Cited by 59 · cited 2×
“[66], the authors demonstrated that curcumin formulated in an Eudragit E (Evonik Nutrition & Care GmbH, Essen, Germany) polymeric matrix dissolved more rapidly (20–45% release after 60 minutes) than curcumin alone (2–5% release after 120 minutes) at pH 1.”
Enhanced Oral Bioavailability of Curcumin Using a Supersaturatable Self-Microemulsifying System Incorporating a Hydrophilic Polymer; In Vitro and In Vivo Investigations
Jaisamut, P., Wiwattanawongsa, K., Graidist, P., Sangsen, Y., & Wiwattanapatapee, R. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0857-3 · Cited by 59
ApoE3 mediated polymeric nanoparticles containing curcumin: Apoptosis induced in vitro anticancer activity against neuroblastoma cells
Mulik, R. S., Mönkkönen, J., Juvonen, R. O., Mahadik, K. R., & Paradkar, A. R. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.062 · Cited by 58 · cited 1×
“85 Anticancer activity in neuroblastoma cells (in vitro model) [98]”
Background
Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation
Singh, A. K., Jiang, Y., Gupta, S., Younus, M., & Ramzan, M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0049 · Cited by 57 · cited 1×
“Metallic nanoparticles Au PEG Lipopolysaccharide-induced inflammation (in vitro and in vivo models) [119]”
Background
Curcumin Inhibits LPS-Induced CCL2 Expression via JNK Pathway in C6 Rat Astrocytoma Cells
Zhang, Z.-J., Zhao, L.-X., Cao, D.-L., Zhang, X., Gao, Y.-J., & Xia, C.-L. (2012) · Cellular and molecular neurobiology · doi:10.1007/s10571-012-9816-4 · Cited by 55 · cited 1×
“[51] investigated the inhibitory effect of curcumin on lipopolysaccharide (LPS)-induced chemokine CCL production.”
Background
Inhibition of IL-6 Signaling Pathway by Curcumin in Uterine Decidual Cells
Devi, Y. S., DeVine, M., DeKuiper, J. L., Ferguson, S. D., & Fazleabas, A. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125627 · Cited by 54 · cited 2×
“[46] reported that curcumin could ex rt a direct effect on constitu ive ignal tr sducer and activator of transcription 3 (STAT3) phosphorylation.”
Background
Ameliorating Amyloid-β Fibrils Triggered Inflammation via Curcumin-Loaded Polymeric Nanoconstructs
Ameruoso, A., Palomba, R., Palange, A. L., Cervadoro, A., Lee, A., Mascolo, D. D., & Decuzzi, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01411 · Cited by 54 · cited 1×
“31 Inflammation model (in vitro model) [96]”
Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting
Meng, F., Asghar, S., Xu, Y., Wang, J., Jin, X., Wang, Z., Wang, J., Ping, Q. N., Zhou, J., & Xiao, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.033 · Cited by 52 · cited 1×
“29 Biodistribution (in vitro and in vivo models) [95]”
Background
Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting
Vaz, G. R., Hädrich, G., Bidone, J., Rodrigues, J. L., Falkembach, M., Putaux, J., Hort, M. A., Monserrat, J. M., Varela, A. S., Teixeira, H. F., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160355 · Cited by 50 · cited 1×
“7 EE ≥ 99 Permeation in Franz cells (ex vivo model) [118]”
Background
Curcumin Attenuates Opioid Tolerance and Dependence by Inhibiting Ca2+/Calmodulin-Dependent Protein Kinase II α Activity
Hu, X., Huang, F. P., Szymusiak, M., Liu, Y., & Wang, Z. J. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219303 · Cited by 49 · cited 1×
“PLGA Opioid tolerance and dependence (in vivo model) [101]”
Background
Curcumin nanoconjugate inhibits aggregation of N-terminal region (Aβ-16) of an amyloid beta peptide
Brahmkhatri, V. P., Sharma, N., Sunanda, P., D’Souza, A., Raghothama, S., & Atreya, H. S. (2018) · New Journal of Chemistry · doi:10.1039/c8nj03541e · Cited by 49 · cited 1×
“[35] reported that curcumin-loaded gold nanoparticles inhibited Aβ aggregation, and that these were capable of dissolving aggregates.”
Background
Preparation and in-vitro/in-vivo evaluation of curcumin nanosuspension with solubility enhancement
Li, X., Yuan, H., Zhang, C., Chen, W., Cheng, W., Chen, X., & Ye, X. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12575 · Cited by 48 · cited 1×
“[69] found an increase in bioavailability after the intravenous administration of a nanosuspension of about 4.”
Background
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Authors: Del Prado-Audelo, M. L., Caballero-Florán, I. H., Meza-Toledo, J. A., Mendoza-Muñoz, N., González-Torres, M., Florán, B., Cortés, H., & Leyva-Gómez, G.
Affiliations: Laboratorio de Posgrado en Tecnología Farmacéutica, FES-Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54740, Mexico
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Universidad del Valle de México (MX)
Facultad de Ciencias Químicas, Universidad de Colima, C.P. Colima 28400, México
CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México 14389, Mexico
Departamento de Fisiología, Biofísica & Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico
Instituto Nacional de Rehabilitación (MX)
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, C.P. Ciudad de México 04510, Mexico
Corresponding author: Cortés, Hernán
ORCID: Caballero-Florán, Isaac H.
Mendoza-Muñoz, Néstor
González-Torres, Maykel
Florán, Benjamín
Cortés, Hernán
Venue: Biomolecules
Publisher: MDPI AG
Published: 2019-02-08
Volume: 9
Issue: 2
Pages: 56
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom9020056
PMC: PMC6406762
OpenAlex: W2913877945
Cited by: 191
References: 129
Citations by year: 2026: 18 · 2025: 28 · 2024: 22 · 2023: 30 · 2022: 26 · 2021: 35 · 2020: 21 · 2019: 11
FWCI: 1.54
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (PAPIIT TA 200318)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: curcumin, curcumin nanoparticles, brain disorders, nanoparticle drug delivery, bioavailability, water solubility, anti-inflammatory activity, antioxidant activity, polyphenols, neurodegenerative diseases
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Brain Diseases, Curcumin, Humans, Temperature, Molecular Structure, Curcuma, Nanoparticles

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