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Cited by 25Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase SignalingMechanisms of cancer metastasis

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The Role of WAVE2 Signaling in Cancer

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Rana, Priyanka Shailendra, Alkrekshi, Akram, Wang, Wei, Markovic, Vesna, Sossey-Alaoui, Khalid·2021·Biomedicines
DOI 10.3390/biomedicines9091217PMC PMC8464821
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Abstract

The Wiskott-Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE)-WAVE1, WAVE2 and WAVE3 regulate rapid reorganization of cortical actin filaments and have been shown to form a key link between small GTPases and the actin cytoskeleton. Upon receiving upstream signals from Rho-family GTPases, the WASP and WAVE family proteins play a significant role in polymerization of actin cytoskeleton through activation of actin-related protein 2/3 complex (Arp2/3). The Arp2/3 complex, once activated, forms actin-based membrane protrusions essential for cell migration and cancer cell invasion. Thus, by activation of Arp2/3 complex, the WAVE and WASP family proteins, as part of the WAVE regulatory complex (WRC), have been shown to play a critical role in cancer cell invasion and metastasis, drawing significant research interest over recent years. Several studies have highlighted the potential for targeting the genes encoding either part of or a complete protein from the WASP/WAVE family as therapeutic strategies for preventing the invasion and metastasis of cancer cells. WAVE2 is well documented to be associated with the pathogenesis of several human cancers, including lung, liver, pancreatic, prostate, colorectal and breast cancer, as well as other hematologic malignancies. This review focuses mainly on the role of WAVE2 in the development, invasion and metastasis of different types of cancer. This review also summarizes the molecular mechanisms that regulate the activity of WAVE2, as well as those oncogenic pathways that are regulated by WAVE2 to promote the cancer phenotype. Finally, we discuss potential therapeutic strategies that target WAVE2 or the WAVE regulatory complex, aimed at preventing or inhibiting cancer invasion and metastasis.

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Metadata

Authors
Rana, P. S., Alkrekshi, A., Wang, W., Markovic, V., & Sossey-Alaoui, K.
Affiliations
  • MetroHealth Medical Center (US)
  • MetroHealth Medical Center, Cleveland, OH 44109, USA
  • Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
ORCID
Venue
Biomedicines
Publisher
MDPI AG
Published
2021-09-14
Volume
9
Issue
9
Pages
1217
ISSN
2227-9059 (ISSN-L)
DOI
10.3390/biomedicines9091217
PMC
PMC8464821
OpenAlex
W3199192392
Cited by
25
References
6
Citations by year
2026: 1 · 2025: 8 · 2024: 4 · 2023: 10 · 2022: 2
FWCI
0.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicines (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Cancer Institute (R01CA226921)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
WAVE2, WAVE regulatory complex, WASP family proteins, Arp2/3 complex, actin cytoskeleton remodeling, Rho GTPases, tumor invasion, metastasis, cell migration, oncogenic signaling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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