Exercise effects on depression: Possible neural mechanisms
Open accessAbstract
Depression is a syndrome of stress- and emotion-dysregulation, involving compromised structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric reductions in the hippocampus, anterior cingulate cortex, prefrontal cortex, striatum, and amygdala, as well as compromised white matter integrity are frequently observed in depressed adults. Exercise has shown promise as an effective treatment for depression, but few studies have attempted to characterize or identify the neural mechanisms of these effects. In this review, we examined the overlap between structural brain abnormalities in depression and the effects of exercise on brain structure in adults, to highlight possible neural mechanisms that may mediate the positive effects of exercise on depressive symptoms. The prefrontal cortex, anterior cingulate cortex, hippocampus, and corpus callosum emerged as structural neural markers that may serve as targets for exercise-based treatments for depression. These findings highlight the need for randomized exercise interventions to test these proposed neurobiological mechanisms of exercise on depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most studies report that the cause of depression is related to the dysfunction of neurotransmitters such as serotonin, dopamine, and norepinephrine.
“At present, most studies report that the cause of depression is related to the dysfunction of neurotransmitters such as serotonin (5-hydroxytryptamine), dopamine, and norepinephrine [61].”
From Systematic review and meta-analysis of the effects of exercise on depression in adolescents (2022) · cites this paper as [61]
Most of the brain regions that have enhanced activation and function following exercise training are well known for their importance in affective reactivity within the DMN pathways, particularly the ventromedial PFC and its regulation of reactivity within subcortical and insular brain regions.
“Indeed, most of the brain regions that have enhanced activation and function following exercise training are well known for their importance in affective reactivity within the DMN pathways, particularly the ventromedial PFC and its regulation of reactivity within subcortical and insular brain regions (83).”
From The Role of Exercise in Management of Mental Health Disorders: An Integrative Review (2021) · cites this paper as [83]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Self-citationA Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 2× · see citing works
“Similar to findings of the hippocampus, abnormalities in the ACC may precede the onset of depression and may persist after remission from a depressive episode, suggesting that volume reductions in the ACC may represent a neurodevelopmental biomarker of risk for depression (49).”
BackgroundResultAerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134 · see citing works
Self-citationCooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub6 · Cited by 1,834 · see citing works
Snyder, H. R. (2013) · Psychological Bulletin · doi:10.1037/a0028727 · Cited by 1,667 · see citing works
An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172 · see citing works
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works
The subgenual anterior cingulate cortex in mood disorders
Drevets, W. C., Savitz, J., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900013754 · Cited by 1,109 · see citing works
Cuijpers, P., Berking, M., Andersson, G., Quigley, L., Kleiboer, A., & Dobson, K. S. (2013) · The Canadian Journal of Psychiatry · doi:10.1177/070674371305800702 · Cited by 1,066 · see citing works
Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months
Babyak, M., Blumenthal, J. A., Herman, S., Khatri, P., Doraiswamy, M., Moore, K., Edward Craighead, W., Baldewicz, T. T., & Ranga Krishnan, K. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00006 · Cited by 1,063 · see citing works
Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Risk for recurrence in depression
Burcusa, S. L., & Iacono, W. G. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.02.005 · Cited by 1,023 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Self-citationAerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works
Self-citationThe vascular depression hypothesis: mechanisms linking vascular disease with depression
Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works
Self-citationKoolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895 · see citing works
Kempton, M. J., Salvador, Z., Munafò, M. R., Geddes, J. R., Simmons, A., Frangou, S., & Williams, S. C. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.60 · Cited by 886 · see citing works
Bora, E., Fornito, A., Pantelis, C., & Yücel, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.049 · Cited by 763 · see citing works
McKinnon, M. C., Yucel, K., Nazarov, A., & MacQueen, G. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0905 · Cited by 742 · see citing works
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.014 · Cited by 682 · see citing works
Physical activity and likelihood of depression in adults: a review
Teychenne, M., Ball, K., & Salmon, J. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.01.009 · Cited by 677 · see citing works
Physical activity, fitness, and gray matter volume
Erickson, K. I., Leckie, R. L., & Weinstein, A. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.034 · Cited by 630 · see citing works
Self-citationVoss, M. W., Heo, S., Prakash, R. S., Erickson, K. I., Alves, H., Chaddock, L., Szabo, A. N., Mailey, E. L., Wójcicki, T. R., White, S. M., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22119 · Cited by 553 · see citing works
Self-citationExercise as a Mean to Control Low‐Grade Systemic Inflammation
Mathur, N., & Pedersen, B. K. (2008) · Mediators of Inflammation · doi:10.1155/2008/109502 · Cited by 514 · see citing works
Interpersonal Psychotherapy for Depression: A Meta-Analysis
Cuijpers, P., Geraedts, A. S., van Oppen, P., Andersson, G., Markowitz, J. C., & van Straten, A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10101411 · Cited by 511 · see citing works
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
Arnone, D., McIntosh, A. M., Ebmeier, K. P., Munafò, M. R., & Anderson, I. M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.05.003 · Cited by 495 · see citing works
Liao, Y., Huang, X., Wu, Q., Yang, C., Kuang, W., Du, M., Lui, S., Yue, Q., Chan, R. C. K., Kemp, G. J., et al. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110180 · Cited by 465 · see citing works
Behavioral activation treatments for depression in adults: A meta-analysis and review.
Mazzucchelli, T., Kane, R., & Rees, C. (2009) · Clinical Psychology: Science and Practice · doi:10.1111/j.1468-2850.2009.01178.x · Cited by 438 · see citing works
Sacher, J., Neumann, J., Fünfstück, T., Soliman, A., Villringer, A., & Schroeter, M. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.001 · Cited by 410 · see citing works
Exercise Benefits Brain Function: The Monoamine Connection
Lin, T.-W., & Kuo, Y.-M. (2013) · Brain Sciences · doi:10.3390/brainsci3010039 · Cited by 392 · see citing works
Hippocampal changes associated with early-life adversity and vulnerability to depression
Rao, U., Chen, L.-A., Bidesi, A. S., Shad, M. U., Thomas, M. A., & Hammen, C. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.017 · Cited by 383 · see citing works
Vascular hippocampal plasticity after aerobic exercise in older adults.
Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.114 · Cited by 382 · see citing works
Russo-Neustadt, A. A., Beard, R., Huang, Y.-M., & Cotman, C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00349-3 · Cited by 382 · see citing works
Antidepressants versus placebo for depression in primary care
Arroll, B., Elley, C. R., Fishman, T., Goodyear‐Smith, F., Kenealy, T. W., Blashki, G. A., Kerse, N. M., & MacGillivray, S. A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007954 · Cited by 353 · see citing works
Weinstein, A. M., Voss, M. W., Prakash, R. S., Chaddock, L., Szabo‐Reed, A. N., White, S. M., Wójcicki, T. R., Mailey, E. L., McAuley, E., Kramer, A. F., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.008 · Cited by 342 · see citing works
Self-citationAntidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?
Ernst, C., Olson, A. K., Pinel, J. P. J., Lam, R. W., & Christie, B. R. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0610 · Cited by 322 · see citing works
Cole, J., Costafreda, S. G., McGuffin, P., & Fu, C. H. Y. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.057 · Cited by 319 · see citing works
Wise, T., Raduà, J., Nortje, G., Cleare, A. J., Young, A. H., & Arnone, D. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.004 · Cited by 304 · see citing works
State-dependent changes in hippocampal grey matter in depression
Arnone, D., McKie, S., Elliott, R., Juhasz, G., Thomas, E. J., Downey, D., Williams, S., Deakin, J. F. W., & Anderson, I. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.150 · Cited by 287 · see citing works
Risk factors for chronic depression—a systematic review
Hölzel, L., Härter, M., Reese, C., & Kriston, L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.03.025 · Cited by 285 · see citing works
Bora, E., Harrison, B. J., Davey, C. G., Yücel, M., & Pantelis, C. (2012) · Psychological Medicine · doi:10.1017/s0033291711001668 · Cited by 276 · see citing works
Sexton, C. E., Betts, J. F., Demnitz, N., Dawes, H., Ebmeier, K. P., & Johansen‐Berg, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.071 · Cited by 256 · see citing works
Whittle, S., Lichter, R., Dennison, M., Vijayakumar, N., Schwartz, O., Byrne, M. L., Simmons, J. G., Yücel, M., Pantelis, C., McGorry, P. D., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070920 · Cited by 247 · see citing works
Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education
Gordon, B. A., Rykhlevskaia, E. I., Brumback, C. R., Lee, Y., Elavsky, S., Konopack, J. F., McAuley, E., Kramer, A. F., Colcombe, S. J., Gratton, G., et al. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00676.x · Cited by 245 · see citing works
Flöel, A., Ruscheweyh, R., Krüger, K., Willemer, C., Winter, B., Völker, K., Lohmann, H., Zitzmann, M., Mooren, F. C., Breitenstein, C., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.043 · Cited by 243 · see citing works
Localization of function in anterior cingulate cortex: From psychosurgery to functional neuroimaging
Gasquoine, P. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.002 · Cited by 240 · see citing works
Voxelwise meta-analysis of gray matter reduction in major depressive disorder
Du, M.-Y., Wu, Q.-Z., Yue, Q., Li, J., Liao, Y., Kuang, W.-H., Huang, X.-Q., Chan, R. C. K., Mechelli, A., & Gong, Q.-Y. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.09.014 · Cited by 237 · see citing works
Exercise moderates age-related atrophy of the medial temporal lobe
Bugg, J. M., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.008 · Cited by 236 · see citing works
Decreased hippocampal volume in healthy girls at risk of depression
Chen, M. C., Hamilton, J. P., & Gotlib, I. H. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.202 · Cited by 220 · see citing works
The effect of midlife physical activity on structural brain changes in the elderly
Rovio, S., Spulber, G., Nieminen, L. J., Niskanen, E. I., Winblad, B. G., Tuomilehto, J., Nissinen, A. M., Soininen, H. S., & Kivipelto, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.007 · Cited by 211 · see citing works
A Systematic Review and Meta-Analysis of Magnetic Resonance Imaging Studies in Late-Life Depression
Sexton, C. E., Mackay, C. E., & Ebmeier, K. P. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.10.019 · Cited by 210 · see citing works
Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E. A., Tiemeier, H. W., Albert Hofman, D., Niessen, W. J., et al. (2015) · QUT ePrints (Queensland University of Technology) · Cited by 207 · see citing works
Zhao, Y.-J., Du, M.-Y., Huang, X.-Q., Lui, S., Chen, Z.-Q., Liu, J., Luo, Y., Wang, X.-L., Kemp, G. J., & Gong, Q.-Y. (2014) · Psychological Medicine · doi:10.1017/s0033291714000518 · Cited by 203 · see citing works
Murphy, M. L., & Frodl, T. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-3 · Cited by 195 · see citing works
Gray matter volume in major depressive disorder: A meta-analysis of voxel-based morphometry studies
Lai, C.-H. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.06.006 · Cited by 191 · see citing works
Niemann, C., Godde, B., & Voelcker-Rehage, C. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00170 · Cited by 190 · see citing works
Neuroprotective lifestyles and the aging brain
Gow, A. J., Bastin, M. E., Maniega, S. M., Hernández, M. C. V., Morris, Z., Murray, C. L., Royle, N. A., Starr, J. M., Deary, I. J., & Wardlaw, J. M. (2012) · Neurology · doi:10.1212/wnl.0b013e3182703fd2 · Cited by 188 · see citing works
White matter integrity in physically fit older adults.
Tseng, B. Y., Gundapuneedi, T., Khan, M. A., Diaz-Arrastia, R., Levine, B. D., Lu, H., Huang, H., & Zhang, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.011 · Cited by 157 · see citing works
Johnson, N. F., Kim, C., Clasey, J. L., Bailey, A. L., & Gold, B. T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.032 · Cited by 154 · see citing works
Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., Kolind, S. H., Foxley, S., Jenkinson, M., Nichols, T. E., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.090 · Cited by 152 · cited 1× · see citing works
“9) using a cross-over design found that 6 weeks of aerobic training for 5 days a week, 30 minutes each day, was sufficient to increase hippocampal volume (43).”
MethodInteractive effects of fitness and hormone treatment on brain health in postmenopausal women
Erickson, K. I., Colcombe, S. J., Elavsky, S., McAuley, E., Korol, D. L., Scalf, P. E., & Kramer, A. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.11.016 · Cited by 148 · see citing works
Self-citationZhang, H., Li, L., Wu, M. C., Chen, Z., Hu, X., Chen, Y., Zhu, H., Jia, Z., & Gong, Q. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.011 · Cited by 147 · see citing works
Role of Aerobic Fitness and Aging on Cerebral White Matter Integrity
Marks, B. L., Madden, D. J., Bucur, B., Provenzale, J. M., WHITE, L. E., Cabeza, R. E. L., & Huettel, S. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.022 · Cited by 145 · see citing works
Brain grey matter volume alterations in late-life depression
Du, M., Liu, J., Chen, Z., Huang, X., Li, J., Kuang, W., Yang, Y., Zhang, W., Zhou, D., Bi, F., et al. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130275 · Cited by 141 · see citing works
Dorsal vs Ventral Hippocampal Neurogenesis: Implications for Cognition and Mood
Kheirbek, M. A., & Hen, R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.148 · Cited by 140 · see citing works
Exercise, antidepressant treatment, and BDNF mRNA expression in the aging brain
Garza, A. A., Ha, T., Garcia, C., Chen, M. J., & Russo‐Neustadt, A. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.10.020 · Cited by 138 · see citing works
Oberlin, L. E., Verstynen, T., Burzynska, A. Z., Voss, M. W., Prakash, R. S., Chaddock‐Heyman, L., Wong, C. N., Fanning, J. T., Salerno, E. A., Gothe, N. P., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.053 · Cited by 131 · see citing works
Self-citationMarks, B., Katz, L., Styner, M. A., & Smith, J. K. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.068114 · Cited by 129 · see citing works
Krogh, J., Rostrup, E., Thomsen, C., Elfving, B., Videbech, P., & Nordentoft, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.041 · Cited by 123 · see citing works
Svatkova, A., Mandl, R. C. W., Scheewe, T. W., Cahn, W., Kahn, R. S., & Hulshoff Pol, H. E. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv033 · Cited by 120 · see citing works
Taren, A. A., Venkatraman, V., & Huettel, S. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5762-10.2011 · Cited by 116 · see citing works
Cardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults.
Szabo, A. N., McAuley, E., Erickson, K. I., Voss, M., Prakash, R. S., Mailey, E. L., Wójcicki, T. R., White, S. M., Gothe, N., Olson, E. A., et al. (2011) · Neuropsychology · doi:10.1037/a0022733 · Cited by 110 · see citing works
Verstynen, T., Lynch, B., Miller, D. L., Voss, M. W., Prakash, R. S., Chaddock, L., Basak, C., Szabo‐Reed, A. N., Olson, E. A., Wójcicki, T. R., et al. (2012) · Journal of Aging Research · doi:10.1155/2012/939285 · Cited by 107 · see citing works
Self-citationEspeland, M. A., Erickson, K. I., Neiberg, R. H., Jakicic, J. M., Wadden, T. A., Wing, R. R., Desiderio, L. M., Erus, G., Hsieh, M.-K., Davatzikos, C. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2230 · Cited by 106 · see citing works
Self-citationKleemeyer, M. M., Kühn, S., Prindle, J., Bodammer, N. C., Brechtel, L., Garthe, A., Kempermann, G., Schaefer, S., & Lindenberger, U. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.026 · Cited by 98 · see citing works
Diffusion tensor imaging studies in late‐life depression: systematic review and meta‐analysis
Wen, M., Steffens, D. C., Chen, M., & Zainal, N. H. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4129 · Cited by 95 · see citing works
Physical activity is related to the structural integrity of cerebral white matter
Gons, R. A. R., Tuladhar, A. M., de Laat, K. F., van Norden, A. G. W., van Dijk, E. J., Norris, D. G., Zwiers, M. P., & de Leeuw, F. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a43e33 · Cited by 85 · see citing works
Moderators of response in exercise treatment for depression: A systematic review
Schuch, F. B., Dunn, A. L., Kanitz, A. C., Delevatti, R. S., & Fleck, M. P. D. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.014 · Cited by 84 · see citing works
Cardiorespiratory fitness is associated with white matter integrity in aging
Hayes, S. M., Salat, D. H., Forman, D. E., Sperling, R. A., & Verfaellie, M. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.204 · Cited by 75 · cited 2× · see citing works
“They found that CRF associations with FA in some tracts were similar across high fit older and younger adults, whereas CRF associations with FA in other tracts were only significant in older adults (74).”
BackgroundResultThe neuroscience of depression: Implications for assessment and intervention
Singh, M. K., & Gotlib, I. H. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.08.008 · Cited by 70 · see citing works
Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults
Tian, Q., Erickson, K. I., Simonsick, E. M., Aizenstein, H. J., Glynn, N. W., Boudreau, R. M., Newman, A. B., Kritchevsky, S. B., Yaffe, K. S., Harris, T. B., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt287 · Cited by 70 · see citing works
Self-citationCortical abnormalities and association with symptom dimensions across the depressive spectrum
Lener, M. S., Kundu, P., Wong, E. W., DeWilde, K. E., Tang, C. Y., Balchandani, P., & Murrough, J. W. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.027 · Cited by 52 · see citing works
Head, D. M., Singh, T., & Bugg, J. M. (2012) · Neuropsychology · doi:10.1037/a0027108 · Cited by 51 · see citing works
Cognitive and neural correlates of aerobic fitness in obese older adults.
Bugg, J. M., Shah, K., Villareal, D. T., & Head, D. (2012) · Experimental Aging Research · doi:10.1080/0361073x.2012.659995 · Cited by 47 · see citing works
Hippocampal multimodal structural changes and subclinical depression in healthy individuals
Spalletta, G., Piras, F., Caltagirone, C., & Fagioli, S. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.068 · Cited by 42 · see citing works
Bracht, T., Jones, D. K., Bells, S., Walther, S., Drakesmith, M., & Linden, D. E. J. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1183-3 · Cited by 31 · see citing works
(2015) · BJPsych International · doi:10.1192/s2056474000000696 · Cited by 30 · see citing works
Automated Voxel-Wise Brain DTI Analysis of Fitness and Aging
Liu, Z. (2012) · The Open Medical Imaging Journal · doi:10.2174/1874347101206010080 · Cited by 12 · see citing works
Dedić, G. (2016) · Vojnosanitetski pregled · doi:10.2298/vsp160701216d · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309 · see citing works
Singh, B., Olds, T., Curtis, R., Dumuid, D., Virgara, R., Watson, A., Szeto, K., O'Connor, E., Ferguson, T., Eglitis, E., et al. (2023) · British Journal of Sports Medicine · doi:10.1136/bjsports-2022-106195 · Cited by 1,049 · see citing works
Effects of Exercise on Brain and Cognition Across Age Groups and Health States
Stillman, C. M., Esteban‐Cornejo, I., Brown, B. M., Bender, C. M., & Erickson, K. I. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.04.010 · Cited by 444 · see citing works
Self-citationThe Role of Exercise in Management of Mental Health Disorders: An Integrative Review
Smith, P. J., & Merwin, R. M. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-060619-022943 · Cited by 360 · see citing works
Sedentary behaviors and risk of depression: a meta-analysis of prospective studies
Huang, Y., Li, L., Gan, Y., Wang, C., Jiang, H., Cao, S., & Lu, Z. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0715-z · Cited by 352 · see citing works
The Effects and Mechanisms of Exercise on the Treatment of Depression
Xie, Y., Wu, Z., Sun, L., Zhou, L., Wang, G., Xiao, L., & Wang, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.705559 · Cited by 194 · see citing works
Kandola, A., Ashdown-Franks, G., Stubbs, B., Osborn, D. P. J., & Hayes, J. F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.088 · Cited by 172 · see citing works
Systematic review and meta-analysis of the effects of exercise on depression in adolescents
Wang, X., Cai, Z.-D., Jiang, W.-T., Fang, Y.-Y., Sun, W.-X., & Wang, X. (2022) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-022-00453-2 · Cited by 169 · see citing works
“At present, most studies report that the cause of depression is related to the dysfunction of neurotransmitters such as serotonin (5-hydroxytryptamine), dopamine, and norepinephrine [61].”
BackgroundLiu, L., Tang, J., Liang, X., Li, Y., Zhu, P., Zhou, M., Lu, Q., Deng, Y., Li, J., Wang, Y., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02464-1 · Cited by 113 · see citing works
Physical activity and depression in older adults: the knowns and unknowns
Zhang, S., Xiang, K., Li, S., & Pan, H. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113738 · Cited by 107 · see citing works
The importance of diversity in cognitive neuroscience
Dotson, V. M., & Duarte, A. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14268 · Cited by 115 · see citing works
Sabé, M., Kaiser, S., & Sentissi, O. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.11.002 · Cited by 100 · see citing works
Exercise-Based Interventions for Internet Addiction: Neurobiological and Neuropsychological Evidence
Li, S., Wu, Q., Tang, C., Chen, Z., & Liu, L. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01296 · Cited by 107 · see citing works
Molecular mechanisms of physical exercise on depression in the elderly: a systematic review
Sousa, R. A. L. D., Dias, I. R., de Oliveira, L. R. S., Caria, A. C. I., Monteiro-Júnior, R. S., & Cassilhas, R. C. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06330-z · Cited by 79 · see citing works
Wang, H., Guo, Y., Qiao, Y., Zhang, J., & Jiang, P. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02071-5 · Cited by 72 · see citing works
Fabiano, N., Gupta, A., Fiedorowicz, J. G., Firth, J., Stubbs, B., Vancampfort, D., Schuch, F. B., Carr, L. J., & Solmi, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.071 · Cited by 71 · see citing works
Lambertus, M., Øverberg, L. T., Andersson, K. A., Hjelden, M. S., Hadzic, A., Haugen, Ø. P., Storm‐Mathisen, J., Bergersen, L. H., Geiseler, S. J., & Morland, C. (2020) · Acta Physiologica · doi:10.1111/apha.13587 · Cited by 62 · see citing works
Bourbeau, K., Moriarty, T., Ayanniyi, A., & Zuhl, M. (2020) · Behavioral Sciences · doi:10.3390/bs10070116 · Cited by 56 · see citing works
Zebrafish as an Animal Model for Testing Agents with Antidepressant Potential
Lachowicz, J. I., Niedziałek, K., Rostkowska, E., Szopa, A., Świąder, K., Szponar, J., & Serefko, A. (2021) · Life · doi:10.3390/life11080792 · Cited by 56 · see citing works
Prospects for circadian treatment of mood disorders
Hühne-Landgraf, A., Welsh, D. K., & Landgraf, D. (2018) · Annals of Medicine · doi:10.1080/07853890.2018.1530449 · Cited by 57 · see citing works
Hong, J. S., Kim, S. M., Kang, K. D., Han, D. H., Kim, J. S., Hwang, H., Min, K. J., Choi, T. Y., & Lee, Y. S. (2020) · Mental health and physical activity · doi:10.1016/j.mhpa.2020.100318 · Cited by 53 · see citing works
Bilek, F., Cetisli-Korkmaz, N., Ercan, Z., Deniz, G., & Demir, C. F. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103742 · Cited by 53 · see citing works
Digital Phenotyping and Feature Extraction on Smartphone Data for Depression Detection
Yang, M., Ngai, E. C. ‐., Hu, X., Hu, B., Liu, J., Erol Gelenbe, A., & Leung, V. C. M. (2024) · Proceedings of the IEEE · doi:10.1109/jproc.2025.3542324 · Cited by 54 · see citing works
Félez-Nóbrega, M., Haro, J. M., Vancampfort, D., & Koyanagi, A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.147 · Cited by 52 · see citing works
Guo, Y.-Y., Pai, M., Xue, B., & Lu, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.06.046 · Cited by 52 · see citing works
Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders
Iqbal, J., Huang, G.-D., Xue, Y.-X., Yang, M., & Jia, X.-J. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09374-z · Cited by 48 · see citing works
Huntsman, D. D., & Bulaj, G. W. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19042248 · Cited by 56 · see citing works
Peng, G., Yang, L., Wu, C., Zhang, L. L., Wu, C. Y., Fan, L., Shi, H. W., Hou, J., Zhang, L. M., Ma, X., et al. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104926 · Cited by 50 · see citing works
Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review
Cai, W., & Shen, W.-D. (2018) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x1850026x · Cited by 47 · see citing works
Chen, H., Dong, G., & Li, K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1094583 · Cited by 47 · see citing works
Exercise for depression: A feasibility trial exploring neural mechanisms
Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., Grove, G., Karp, J. F., & Erickson, K. I. (2019) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.01.012 · Cited by 44 · see citing works
Self-citationMaleki, S., Hendrikse, J. J., Chye, Y., Caeyenberghs, K., Coxon, J. P., Oldham, S., Suo, C., & Yücel, M. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00693-y · Cited by 49 · see citing works
Depression in Parkinson's disease: Perspectives from an Australian cohort
Lubomski, M., Davis, R. L., & Sue, C. M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.032 · Cited by 43 · see citing works
Xie, H., Tao, S., Zhang, Y., Tao, F., & Wu, X. (2019) · BMC Public Health · doi:10.1186/s12889-019-7873-z · Cited by 42 · see citing works
Sadighparvar, S., Darband, S. G., Yousefi, B., Kaviani, M., Ghaderi‐Pakdel, F., Mihanfar, A., Babaei, G., Mobaraki, K., & Majidinia, M. (2020) · Experimental Physiology · doi:10.1113/ep088605 · Cited by 41 · see citing works
Relationship of depression and sleep quality, diseases and general characteristics
Jiang, Y., Jiang, T., Xu, L., & Lan, D. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i5.722 · Cited by 45 · see citing works
Celano, C. M., Gianangelo, T., Millstein, R. A., Chung, W., Wexler, D. J., Park, E. R., & Huffman, J. C. (2018) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217418791448 · Cited by 39 · see citing works
Ferreira, T. L. G. D. S., Ribeiro, H. S., Ribeiro, A. L. D. A., Bonini‐Rocha, A. C., de Lucena, J. M. S., de Oliveira, P. A., Santos, F. R. A., Ferreira, A. P., Magno, L. A. V., & Martins, W. R. (2020) · International Urology and Nephrology · doi:10.1007/s11255-020-02612-w · Cited by 39 · see citing works
Amiri, S., Mahmood, N., Javaid, S. F., & Khan, M. A. (2024) · Healthcare · doi:10.3390/healthcare12222263 · Cited by 42 · see citing works
Li, L., Wang, P., Li, S., Liu, Q., Fen, Y., Guo, Z., Jia, S., & Wang, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-38682-w · Cited by 37 · see citing works
Ren, F.-F., Alderman, B. L., Wang, W., Chen, F., Zhou, W.-S., Zong, W.-J., Liang, W.-M., & Chang, Y. (2023) · Sports Medicine · doi:10.1007/s40279-023-01869-2 · Cited by 37 · see citing works
Duarte, J. D. S., Alcantara, W. A., Brito, J. S., Barbosa, L. C. S., Machado, I. P. R., Furtado, V. K. T., Santos‐Lobato, B. L., Pinto, D. S., Krejčová, L. V., & Bahia, C. P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281204 · Cited by 34 · see citing works
Jang, B. N., Lee, H. J., Joo, J. H., Park, E., & Jang, S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02628-7 · Cited by 34 · see citing works
Tourist experience: The catalyst role of tourism in comforting melancholy, or not
Christou, P., & Simillidou, A. (2020) · Journal of Hospitality and Tourism Management · doi:10.1016/j.jhtm.2020.01.007 · Cited by 32 · see citing works
Mental health benefits from lifestyle physical activity interventions: A systematic review
Farris, S. G., & Abrantes, A. M. (2020) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2020.84.4.337 · Cited by 36 · see citing works
Exercise Training in Elderly Cancer Patients: A Systematic Review
Giallauria, F., Testa, C., Cuomo, G., di Lorenzo, A. D., Venturini, E., Lauretani, F., Maggio, M., Iannuzzo, G., & Vigorito, C. (2023) · Cancers · doi:10.3390/cancers15061671 · Cited by 26 · see citing works
Akimoto, H., Tezuka, K., Nishida, Y., Nakayama, T., Takahashi, Y., & Asai, S. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.536 · Cited by 30 · see citing works
Anxiety and depression in school-age patients with spinal muscular atrophy: a cross-sectional study
Yao, M., Xia, Y., Feng, Y., Ma, Y., Hong, Y., Zhang, Y., Chen, J., Yuan, C., & Mao, S. (2021) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-021-02008-8 · Cited by 30 · see citing works
Zhao, Y., Wang, W., Wang, M., Gao, F., Hu, C., Cui, B., Yu, W., & Ren, H. C. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1015725 · Cited by 29 · see citing works
Wang, P., Liang, Y., Chen, K., Yau, S., Sun, X., Cheng, K. K. Y., Xu, A., So, K., & Li, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00189 · Cited by 29 · see citing works
Liang, A., Zhao, S., Song, J., Zhang, Y., Zhang, Y., Niu, X., Xiao, T., & Chi, A. (2021) · Sustainability · doi:10.3390/su13126822 · Cited by 29 · see citing works
Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19
Rebello, C. J., Axelrod, C. L., Reynolds, C. F., Greenway, F. L., & Kirwan, J. P. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000284 · Cited by 28 · see citing works
Self-citationBulaj, G. W., Clark, J. E., Ebrahimi, M., & Bald, E. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.612602 · Cited by 29 · see citing works
Fink, A., Koschutnig, K., Zussner, T., Perchtold‐Stefan, C. M., Rominger, C., Benedek, M., & Papousek, I. (2021) · Cortex · doi:10.1016/j.cortex.2021.08.010 · Cited by 27 · see citing works
Han, D., Zhao, Z., Mao, T., Gao, M., Yang, X., & Gao, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70150 · Cited by 30 · see citing works
Svensson, B., Forslind, K., & Andersson, M. (2020) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2020.1729404 · Cited by 26 · see citing works
Sex differences in type of exercise associated with depression in South Korean adults
Kim, H., Jeong, W., Kwon, J., Kim, Y.-S., Jang, S., & Park, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-75389-8 · Cited by 26 · see citing works
Research progress on rheumatoid arthritis-associated depression
Liu, N., Yan, W., Su, R., Zhang, L., Wang, X., Li, Z., Qin, D., & Peng, J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.992223 · Cited by 26 · see citing works
Liu, X., Wang, G., & Cao, Y. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1022402 · Cited by 24 · see citing works
Patrick, R. E., Dickinson, R. A., Gentry, M. T., Kim, J. U., Oberlin, L. E., Park, S., Principe, J. L., Teixeira, A. L., & Weisenbach, S. L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.017 · Cited by 25 · see citing works
Liu, Y., Zhao, G., Guo, J., Qu, H., Kong, L., & Yue, W. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.074 · Cited by 26 · see citing works
Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention
Hall, P. A., Bickel, W. K., Erickson, K. I., & Wagner, D. D. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13868 · Cited by 23 · see citing works
Self-citationPhysical Activity of Secondary School Adolescents at Risk of Depressive Symptoms
Frömel, K., Jakubec, L., Groffik, D., Chmelík, F., Svozil, Z., & Šafář, M. (2020) · Journal of School Health · doi:10.1111/josh.12911 · Cited by 24 · see citing works
Clinically relevant connectivity features define three subtypes of Parkinson's disease patients
Guo, T., Guan, X., Zhou, C., Gao, T., Wu, J., Song, Z., Xuan, M., Gu, Q., Huang, P., Pu, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25110 · Cited by 23 · see citing works
Le, F., Yap, Y., Tung, N. Y. C., Bei, B., & Wiley, J. F. (2021) · International Journal of Behavioral Medicine · doi:10.1007/s12529-021-10031-z · Cited by 24 · see citing works
Agbangla, N. F., Séba, M.-P., Bunlon, F., Toulotte, C., & Fraser, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20136226 · Cited by 22 · see citing works
Exercise for depression treatment. Physiological mechanisms
Gultyaeva, V. V., Zinchenko, M. I., Uryumtsev, D. Y., Krivoschekov, S. G., & Aftanas, L. I. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2019119071112 · Cited by 23 · see citing works
Zulyniak, S., Williams, J. V. A., Bulloch, A. G. M., Lukmanji, A., & Patten, S. B. (2020) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2020.100021 · Cited by 22 · see citing works
Luo, J., Yao, W., Zhang, T., Ge, H., & Zhang, D. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110678 · Cited by 22 · see citing works
Li, C., Ye, F., Xu, C.-X., Jiang, N., Chang, Q., Liu, X., & Pan, R. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.008 · Cited by 28 · see citing works
Soares, E. F. P., Reis, J., Rodrigues, M. F., Ribeiro, C., & Pereira, F. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020542 · Cited by 22 · see citing works
Li, L., Wang, P., Zhao, Q., Liu, Z., Li, S., & Wang, X. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.214 · Cited by 21 · see citing works
Huang, A. A., & Huang, S. Y. (2023) · Health Science Reports · doi:10.1002/hsr2.1473 · Cited by 21 · see citing works
Dotson, V. M., Gradone, A. M., Bogoian, H. R., Minto, L. R., Taiwo, Z., & Salling, Z. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000710 · Cited by 19 · see citing works
Yuan, Y., Lü, L., Zhang, N., Xie, C., Liang, J., Qi, Y., Dong, B., & Tian, L. (2021) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.06.020 · Cited by 20 · see citing works
Cao-Lei, L., Yogendran, S., Dufoix, R., Elgbeili, G., Laplante, D. P., & King, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.706660 · Cited by 21 · see citing works
Khoury, R., & Nagy, C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1154872 · Cited by 18 · see citing works
Li, J., Zhou, Z., Hao, S., & Zang, L. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05688-9 · Cited by 22 · see citing works
Budde, H., Dolz, N., Mueller‐Alcazar, A., Schacht, F., Velasques, B., Ribeiro, P. F. M., Machado, S. E. D. C., & Wegner, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317610 · Cited by 19 · see citing works
Wieman, S. T., Fields, J. S., Hall, K. A. A., MacDonald, H. Z., & Liverant, G. I. (2022) · Journal of American College Health · doi:10.1080/07448481.2022.2047705 · Cited by 19 · see citing works
Feller, D., Fox, I., Gozzer, P., Trentin, F., & Papola, D. (2022) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2022.07.021 · Cited by 19 · see citing works
Lardier, D. T., Zuhl, M., Holladay, K. R., Amorim, F. T., Heggenberger, R., & Coakley, K. E. (2022) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00722-9 · Cited by 20 · see citing works
Depressive symptoms in older adults: the role of physical activity and social support
Moya, C. A. M., Soares, F. C., Lima, R. A., de Barros, M. V. G., & Bezerra, J. (2021) · Trends in Psychiatry and Psychotherapy · doi:10.47626/2237-6089-2020-0093 · Cited by 18 · see citing works
McEwen, S. C., Jarrahi, B., Ventura, J., Subotnik, K. L., Nguyen, J., Woo, S. M., & Nuechterlein, K. H. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.12.001 · Cited by 18 · see citing works
Hong, Y., Shen, J., Hu, Y., Gu, Y., Bai, Z., Chen, Y., & Huang, S. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1384035 · Cited by 18 · see citing works
Breakdown of the blood-brain barrier in depressed mice induced by chronic unpredictable mild stress
Shi, W., Zhang, S., Yao, K., Meng, Q., Lu, Y., Ren, Y., Li, L., & Zhao, J. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.10.004 · Cited by 20 · see citing works
Sánchez‐Carro, Y., Portella, M. J., Leal‐Leturia, I., Salvat‐Pujol, N., Etxandi, M., de Arriba‐Arnau, A., Urretavizcaya, M., Pousa, E., Toll, A., Álvarez, P., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.032 · Cited by 18 · see citing works
Geng, C., Qiao, Y., Guo, Y., Han, W., Wu, B., Wang, C., Zhang, J., Chen, D., Yang, M., & Jiang, P. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.21 · Cited by 17 · see citing works
Yu, H., Mu, Q., Lv, X., Chen, S., & He, H. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1473710 · Cited by 21 · see citing works
Liu, X., Wang, G., & Cao, Y. (2023) · Geriatric Nursing · doi:10.1016/j.gerinurse.2023.03.013 · Cited by 18 · see citing works
Liu, X., Zhong, S., Yan, L., Zhao, H., Wang, Y., Hu, Y., & Jia, Y. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa038 · Cited by 17 · see citing works
Ye, J., Wu, C., Chu, X., Wen, Y. F., Li, P., Cheng, B., Cheng, S., Liu, L., Zhang, L., Ma, M., et al. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.74 · Cited by 17 · see citing works
Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota
Zeppa, S. D., Ferrini, F., Agostini, D., Amatori, S., Barbieri, E., Piccoli, G., Sestili, P., & Stocchi, V. (2022) · Antioxidants · doi:10.3390/antiox11020236 · Cited by 18 · see citing works
Amiri, S. (2022) · Neuropsychiatrie · doi:10.1007/s40211-022-00431-2 · Cited by 16 · see citing works
Reine, S., Xi, Y., Archer, H., Chhabra, A. B., Huo, M. H., & Wells, J. E. (2022) · The Journal of Arthroplasty · doi:10.1016/j.arth.2022.12.026 · Cited by 18 · see citing works
Li, S., Wang, X., Wang, P., Qiu, S., Xin, X., Wang, J., Zhao, J., & Zhou, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-43765-9 · Cited by 16 · see citing works
Luu, B., Gupta, A. A., Fabiano, N., Wong, S., Fiedorowicz, J. G., Fidler, L. M., Shorr, R., & Solmi, M. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107433 · Cited by 16 · see citing works
Weng, W.-H., Wang, Y.-H., Yeh, N.-C., Yang, Y., & Wang, R. (2024) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2024.100237 · Cited by 18 · see citing works
Possible antidepressant mechanism of acupuncture: targeting neuroplasticity
Xu, N., He, Y., Wei, Y.-N., Bai, L., & Wang, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1512073 · Cited by 19 · see citing works
Fu, C., Shuang, Q., Liu, Y., Zeng, L., & Su, W. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00439 · Cited by 15 · see citing works
- Authors
- Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., & Erickson, K. I.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Gujral, Swathi
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 49
- Pages
- 2-10
- ISSN
- 0163-8343 (ISSN-L)
- PMC
- PMC6437683
- OpenAlex
- W2767771037
- Cited by
- 334
- References
- 97
- Citations by year
- 2026: 33 · 2025: 42 · 2024: 55 · 2023: 67 · 2022: 40 · 2021: 34 · 2020: 40 · 2019: 12 · 2018: 10
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 371 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- General Hospital Psychiatry (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (P30 MH090333, R01 DK095172, P30 AG024827, P30 MH90333, P50 AG005133, 2014192810)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- physical activity, depression, neural mechanisms, brain structure, hippocampus, anterior cingulate cortex, prefrontal cortex, corpus callosum, white matter integrity, structural brain abnormalities, neuroplasticity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Brain, Depression, Depressive Disorder, Exercise Therapy, Humans, Middle Aged, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
