The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin
Open accessAbstract
A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.
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Citations
Cites
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Cited by
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
RETRACTED: Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Slika, H., Mansour, H., Wehbe, N., Nasser, S. A., Iratni, R., Nasrallah, G., Shaito, A., Ghaddar, T., Kobeissy, F., & Eid, A. H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112442 · Cited by 441
RetractedChen, T., Hu, Y., Cen, Y., Chu, X., & Lu, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4035939 · Cited by 308
Quercetin-Mediated Apoptosis and Cellular Senescence in Human Colon Cancer
Özsoy, S., Becer, E., Kabadayı, H., Vatansever, H. S., & Yücecan, S. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200408082026 · Cited by 62
Metadata
- Authors
- Gibellini, L., Pinti, M., Nasi, M., De Biasi, S., Roat, E., Bertoncelli, L., & Cossarizza, A.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2010-06-14
- Volume
- 2
- Issue
- 2
- Pages
- 1288-1311
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W1976788172
- Cited by
- 263
- References
- 15
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gibellini, L., Pinti, M., Nasi, M., De Biasi, S., Roat, E., Bertoncelli, L., & Cossarizza, A. (2010). Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers. https://doi.org/10.3390/cancers2021288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
