Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats
Open accessAbstract
Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote inflammation and oxidative stress, involved in the etiology of several diseases. Still, these effects have not been investigated in VaD. Here, we tested whether pre-existing, circulating, high levels of TMAO could affect VaD-induced cognitive decline. TMAO (120 mg/kg) was given to rats for a total of 8 weeks, and these rats underwent a sham operation or bilateral common carotid artery (2VO) surgery after 4 weeks of treatment. Four weeks after surgery, the 2VO rats exhibited hippocampal-dependent cognitive function declines and synaptic plasticity dysfunction, accompanied by an increase in oxidative stress, neuroinflammation, and apoptosis. TMAO administration, which increased plasma and hippocampal TMAO at 4 weeks postoperatively, further aggravated these effects, resulting in exaggerated cognitive and synaptic plasticity impairment, though not within the Sham group. Moreover, TMAO treatment activated the NLRP3 inflammasome and decreased SIRT1 protein expression within the hippocampus. However, these effects of TMAO were significantly attenuated by the overexpression of SIRT1. Our findings suggest that TMAO increases oxidative stress-induced neuroinflammation and apoptosis by inhibiting the SIRT1 pathway, thereby exacerbating cognitive dysfunction and neuropathological changes in VaD rats.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the brain, TMAO is detrimental to neuronal physiology as it induces neuronal senescence, oxidative stress, and alters synaptic plasticity.
“In the brain, TMAO is detrimental to neuronal physiology as it induces neuronal senescence, oxidative stress, and alters synaptic plasticity.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [669]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Self-citationThe Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
SIRT1 and other sirtuins in metabolism
Chang, H.-C., & Guarente, L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.001 · Cited by 1,138 · see citing works
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works
Inflammatory caspases and inflammasomes: master switches of inflammation
Martinon, F., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402038 · Cited by 821 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
Juliana, C. A., Fernandes‐Alnemri, T., Kang, S., Farias, A., Qin, F., & Alnemri, E. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407130 · Cited by 771 · see citing works
Global Epidemiology of Dementia: Alzheimer’s and Vascular Types
Rizzi, L., Rosset, I., & Roriz‐Cruz, M. (2014) · BioMed Research International · doi:10.1155/2014/908915 · Cited by 752 · see citing works
Stroke injury, cognitive impairment and vascular dementia
Kalaria, R. N., Akinyemi, R., & Ihara, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.015 · Cited by 647 · see citing works
Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631 · see citing works
Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.013 · Cited by 592 · see citing works
Sun, X., Jiao, X., Ma, Y., Liu, Y., Zhang, L., He, Y., & Chen, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.017 · Cited by 507 · see citing works
Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease
Zeisel, S. H., & Warrier, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064732 · Cited by 475 · see citing works
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
Vogt, N. M., Romano, K. A., Darst, B. F., Engelman, C. D., Johnson, S. C., Carlsson, C. M., Asthana, S., Blennow, K., Zetterberg, H., Bendlin, B. B., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0451-2 · Cited by 471 · see citing works
The neuropathology and cerebrovascular mechanisms of dementia
Raz, L., Knoefel, J. E., & Bhaskar, K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.164 · Cited by 470 · see citing works
Epidemiology of Vascular Dementia
Wolters, F. J., & Ikram, M. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311908 · Cited by 419 · see citing works
SIRT1 and SIRT2: emerging targets in neurodegeneration
Dönmez, G., & Outeiro, T. F. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302451 · Cited by 414 · see citing works
Duncombe, J., Kitamura, A., Hase, Y., Ihara, M., Kalaria, R. N., & Horsburgh, K. J. (2017) · Clinical Science · doi:10.1042/cs20160727 · Cited by 409 · see citing works
Yu, X., Lan, P., Hou, X., Han, Q., Lü, N., Li, T., Jiao, C., Zhang, J., Zhang, C., & Tian, Z. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.018 · Cited by 357 · see citing works
Trimethylamine‐<i>N</i>‐oxide promotes brain aging and cognitive impairment in mice
Li, D., Ke, Y., Zhan, R., Liu, C., Zhao, M., Zeng, A., Shi, X., Ji, L., Cheng, S., Pan, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12768 · Cited by 304 · see citing works
Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction
Boini, K. M., Hussain, T., Li, P.-L., & Koka, S. S. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484623 · Cited by 302 · see citing works
Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.007 · Cited by 285 · see citing works
Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology
Bennett, S., Grant, M. M., & Aldred, S. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1041 · Cited by 254 · see citing works
García, J. A. G., Volt, H., Venegas, C., Doerrier, C., Escames, G., López, L. C., & Acuña-Castroviejo, D. (2015) · The FASEB Journal · doi:10.1096/fj.15-273656 · Cited by 224 · see citing works
NLRP3 Inflammasome as a Novel Player in Myocardial Infarction
Takahashi, M. (2014) · International Heart Journal · doi:10.1536/ihj.13-388 · Cited by 199 · see citing works
Hepatic NAD+ deficiency as a therapeutic target for non‐alcoholic fatty liver disease in ageing
Zhou, C., Yang, X., Hua, X., Liu, J., Fan, M.-B., Li, G., Song, J., Xu, T., Li, Z., Guan, Y., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13513 · Cited by 198 · see citing works
The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid
Del Rio, D., Zimetti, F., Caffarra, P., Tassotti, M., Bernini, F., Brighenti, F., Zini, A., & Zanotti, I. (2017) · Nutrients · doi:10.3390/nu9101053 · Cited by 172 · see citing works
Trimethylamine N‐oxide: breathe new life
Subramaniam, S., & Fletcher, C. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13959 · Cited by 171 · see citing works
A Multi-omic Association Study of Trimethylamine N-Oxide
Manor, O., Zubair, N., Conomos, M. P., Xu, X., Rohwer, J. E., Krafft, C. E., Lovejoy, J. C., & Magis, A. T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.096 · Cited by 161 · see citing works
Mechanisms of Dysfunction of the Nitric Oxide Pathway in Vascular Diseases
Maxwell, A. J. (2002) · Nitric Oxide · doi:10.1006/niox.2001.0394 · Cited by 136 · see citing works
Khan, A., Kalaria, R. N., Corbett, A., & Ballard, C. G. (2016) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988716654987 · Cited by 125 · see citing works
Zhang, R., Wu, Y., Xie, F., Zhong, Y., Wang, Y., Xu, M., Feng, J., Charish, J., Monnier, P. P., & Qin, X. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0058-y · Cited by 122 · see citing works
Gao, Q., Wang, Y., Wang, X., Fu, S., Zhang, X., Wang, R., & Zhang, X. (2019) · Aging · doi:10.18632/aging.102352 · Cited by 118 · see citing works
Yao, H., Tao, X., Xu, L., Qi, Y., Yin, L., Han, X., Xu, Y., Zheng, L., & Peng, J. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.017 · Cited by 104 · see citing works
NADPH Oxidase 1, a Novel Molecular Source of ROS in Hippocampal Neuronal Death in Vascular Dementia
Choi, D.-H., Lee, K.-H., Kim, J.-H., Seo, J.-H., Kim, H. Y., Shin, C. Y., Han, J., Han, S., Kim, Y.-S., & Lee, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5129 · Cited by 102 · see citing works
Jiang, T., Yu, J., Zhu, X., Tan, M., Gu, L.-Z., Zhang, Y., & Tan, L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.026 · Cited by 97 · see citing works
Rosenberg, G. A., Bjerke, M., & Wallin, A. (2014) · Stroke · doi:10.1161/strokeaha.113.004534 · Cited by 96 · see citing works
Feng, X., Degos, V., Koch, L. G., Britton, S. L., Zhu, Y., Vacas, S., Terrando, N., Nelson, J., Su, X., & Maze, M. (2013) · Anesthesiology · doi:10.1097/aln.0b013e318286d0c9 · Cited by 84 · see citing works
Zhanbo, F., Lu, Y., Wu, X., Zhao, P., Li, J., Peng, B., Qian, Z., & Zhu, L. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.09.014 · Cited by 83 · see citing works
Meng, F., Li, N., Li, D., Song, B., & Li, L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111902 · Cited by 67 · see citing works
Hattori, Y., Okamoto, Y., Maki, T., Yamamoto, Y., Oishi, N., Yamahara, K., Nagatsuka, K., Takahashi, R., Kalaria, R. N., Fukuyama, H., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.006265 · Cited by 63 · see citing works
Zhang, H., Meng, J., & Yu, H. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00944 · Cited by 59 · see citing works
The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury
Yan, T., Huang, J., Nisar, M. F., Wan, C. C., & Huang, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8506195 · Cited by 59 · see citing works
Li, M., Meng, N., Guo, X., Niu, X., Zhao, Z., Wang, W., Xie, X., & Lv, P. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00137 · Cited by 51 · see citing works
Liu, C., Wu, Y., Zha, S., Liu, M., Wang, Y., Yang, G., Ma, K., Fei, Y., Zhang, Y., Hu, X., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.040 · Cited by 48 · see citing works
Zhao, L., Zhang, C., Cao, G., Dong, X., Li, D., & Jiang, L. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02868-4 · Cited by 46 · see citing works
Dong, F., Jiang, S., Tang, C., Wang, X., Ren, X., Wei, Q., Tian, J., Hu, W., Guo, J. Z., Fu, X., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.010 · Cited by 44 · see citing works
Self-citationWang, R., Wu, Z., Bai, L., Liu, R., Ba, Y., Zhang, H., Cheng, X., Zhou, G., & Huang, H. (2021) · Environmental Toxicology · doi:10.1002/tox.23162 · Cited by 41 · see citing works
AIM2 deletion promotes neuroplasticity and spatial memory of mice
Chen, J., Shu, S., Chen, Y., Liu, Z., Yu, L., Yang, L., Xu, Y., & Zhang, M. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.011 · Cited by 30 · see citing works
Self-citationYang, C.-C., & Yang, C. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s293135 · Cited by 27 · see citing works
Choi, S. A., Chong, S., Kwak, P. A., Moon, Y. J., Jangra, A., Phi, J. H., Lee, J. Y., Park, S., & Kim, S. (2018) · Journal of Neurosurgery Pediatrics · doi:10.3171/2018.8.peds1883 · Cited by 23 · see citing works
Yang, G., & Zhang, X. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_12_21 · Cited by 21 · see citing works
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury
Zhang, Q., Fan, Z., Wei, X., Sun, F., Zhu, H., Huang, D., Wang, Z., & Dong, L. (2021) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2021-0034 · Cited by 17 · see citing works
Yin, Y., Liu, Y., Zhu, M., Wang, H., Qiu, Y., Wan, G., & Li, P. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113777 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Chen, C., Wang, G., Li, D., & Zhang, F. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00307-1 · Cited by 119 · see citing works
Quan, W., Qiao, C.-M., Niu, G.-Y., Wu, J., Zhao, L.-P., Cui, C., Zhao, W.-J., & Shen, Y.-Q. (2023) · Brain Sciences · doi:10.3390/brainsci13050790 · Cited by 49 · see citing works
Xie, H., Jiang, J., Cao, S., Xu, X., Zhou, J., Zhang, R., Huang, B., Lu, P., Peng, L., & Liu, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031373 · Cited by 33 · see citing works
Alterations of the blood-brain barrier during aging
Cao, Y., Xu, W., & Liu, Q. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241240843 · Cited by 29 · see citing works
Guo, M., Fang, L., Chen, M., Shen, J., Tan, Z., & He, W. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1354823 · Cited by 24 · see citing works
Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions
Madhamanchi, K., Zhang, J., & Melkani, G. C. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.011 · Cited by 30 · see citing works
Guo, H., Tang, X., He, X., Weng, Y., Zhang, Q., Fang, Q., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15070920 · Cited by 27 · see citing works
Shi, Y., Wang, P., Deng, J., Chen, Y., Wang, F., Han, Y., Wang, H., Yang, L., Fang, X., Hui, J., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01846-z · Cited by 21 · see citing works
Olejnik, P., & Golenia, A. (2024) · Cells · doi:10.3390/cells13231962 · Cited by 20 · see citing works
Targeting sirtuins in neurological disorders: A comprehensive review
Zhang, S.-Y., Yang, N., Hao, P.-H., Wen, R., & Zhang, T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139258 · Cited by 19 · see citing works
The role of gut microbiota‐derived metabolites in neuroinflammation
Mu, L., & Wang, Y. (2025) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70001 · Cited by 21 · see citing works
Han, J. H., Rey, F. E., & Denu, J. M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110521 · Cited by 20 · see citing works
Liu, Y., Liu, Q., Wang, H., Qiu, Y., Lin, J.-T., Wu, W.-F., Wang, N., Dong, W., Wan, J., Chen, C., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14410 · Cited by 18 · see citing works
Liu, J., Ge, P., Luo, Y., Sun, Z., Luo, X., Li, H., Pei, B., Xun, L., Zhang, X., Jiang, Y., et al. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s512207 · Cited by 19 · see citing works
Long, C., Li, Z., Feng, H., Jiang, Y., Pu, Y., Tao, J., & Yue, R. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1465457 · Cited by 16 · see citing works
Wang, Y., Shen, S., Sun, Y., Zhou, S., Zhang, X., Song, Z., Sun, M., Jiang, S., Qian, C., Zhang, Q., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00599-1 · Cited by 15 · see citing works
Zhang, L., Chen, Y., Fan, Y., & Shi, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-57080-4 · Cited by 12 · see citing works
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway
Bai, L., Chen, Q., Li, Y., Wu, F., Jin, M., Chen, Y., Teng, X., Jin, S., Fan, H.-J., & Wu, Y. (2024) · Physiological Research · doi:10.33549/physiolres.935378 · Cited by 12 · see citing works
Pelvic irradiation induces behavioural and neuronal damage through gut dysbiosis in a rat model
Venkidesh, B. S., Narasimhamurthy, R. K., Jnana, A., Reghunathan, D., Sharan, K., Chandraguthi, S. G., Saigal, M., Murali, T. S., & Mumbrekar, K. D. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110775 · Cited by 12 · see citing works
Ye, H.-M., Li, Z., Zhang, P., Kang, Z., & Zhou, D.-S. (2024) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-024-3766-9 · Cited by 11 · see citing works
Ghalwash, A. A., El‐Gohary, R. M., Amrousy, D. M. E., Morad, L. M., Kassem, S. S., Hegab, I. I., & okasha, A. H. (2024) · Pediatric Research · doi:10.1038/s41390-024-03639-w · Cited by 11 · see citing works
Xie, X., Ge, W., Luo, Y., Xing, X., & Sun, X. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178091 · Cited by 8 · see citing works
Zhu, H., He, H., Yang, M., Zhu, H., Hagiwara, A., Shu, L., Xu, J., Miao, Y., Han, X., & Wang, C. (2025) · iScience · doi:10.1016/j.isci.2025.114044 · Cited by 8 · see citing works
Liu, T., Li, Y., Xiong, X., Lai, X., & Xu, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1648800 · Cited by 8 · see citing works
Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder
Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 7 · see citing works
Deng, Y., Zou, J., Hong, Y., Peng, Q., Li, Z., Chen, X., Ge, S., Chen, X., 张颖冬, & Duan, R. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s479154 · Cited by 7 · see citing works
Self-citationBockus, A. B., Powell, M. S., Sealey, W. M., Zito, P., Kurerov, Y., Sbisa, T., Carrillo‐Longoria, J., & Gaylord, T. G. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741810 · Cited by 7 · see citing works
Gong, H., Liu, Y., Xiaoluo, Q.-L., Gong, M.-F., Liu, Z., Wu, S., Chen, Z.-Y., Liu, T.-Y., Zhao, J., Wang, L. Y., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1679858 · Cited by 6 · see citing works
Gao, W., Li, Z., Yang, C., Lin, Y. Z., & Wang, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114730 · Cited by 5 · see citing works
Zhang, H., Ren, K., Ni, X., Lin, L., Li, L., Zhang, W., Gao, Z., Ren, S., Lili, F., & Hai, X. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118691 · Cited by 5 · see citing works
Leng, S.-Y., Yang, Q., Yuan, Y., Chen, B., Chen, H., Ban, W., & Zhang, J. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1677896 · Cited by 5 · see citing works
Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders
Mirji, G., Bhat, S. A., & Shinde, R. S. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.02.008 · Cited by 5 · see citing works
Ikewaki, N., Hegde, M. L., Rao, K. S. J., Raghavan, K., Yamamoto, N., Ichiyama, K., Senthilkumar, R., Preethy, S., & Abraham, S. J. (2025) · Future Neurology · doi:10.1080/14796708.2025.2505398 · Cited by 3 · see citing works
In vivo mechanism of the interaction between trimethylamine lyase expression and glycolytic pathways
Li, Q., Wu, D., Song, Y., Zhang, L., Wang, T., Chen, X., & Zhang, M. (2024) · Food & Function · doi:10.1039/d4fo03809f · Cited by 3 · see citing works
Self-citationThe Vicious Consequences of Chronic Kidney Disease on Cognitive Impairment and Alzheimer’s Disease
Roy, A., Roy, R., Bhattacharya, P., & Borah, A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00050 · Cited by 6 · see citing works
Study on the pathogenesis of vascular dementia by gene expression regulatory network
Bai, H. (2025) · Gene · doi:10.1016/j.gene.2025.149749 · Cited by 1 · see citing works
Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?
Fu, C., Zhang, X., Qian, Y., Wang, X., Chen, X., Zeng, J. S., Zhang, N., Wang, L., Li, M., Li, Z., et al. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02103-y · Cited by 1 · see citing works
Self-citationGupta, D. K., & Kumar, R. (2026) · Cureus · doi:10.7759/cureus.103206 · Cited by 1 · see citing works
The gut–brain axis and trimethylamine N-oxide: an emergent biomarker in neurological diseases
Arangia, A., Paola, R. D., Cuzzocrea, S., Siracusa, R., D’Amico, R., & Impellizzeri, D. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.005 · Cited by 1 · see citing works
Is Ergothioneine an Important Source of Plasma Trimethylamine N-Oxide in Humans?
Cheah, I. K.-M., Wu, L. H., Tang, R. M. Y., Rieprecht, U., Pakkiri, L. S., Richards, A. M., Drum, C. L., & Halliwell, B. B. (2026) · Antioxidants · doi:10.3390/antiox15070819 · Cited by 1 · see citing works
Xiao, J., Tian, X., Fu, Y., Xia, J., Chen, Z., Yin, X., & Chen, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1878545 · Cited by 1 · see citing works
Self-citationLei, C., Cao, L., Jiang, J., Hu, J., Xiong, G., & Lv, S. (2026) · International Journal of Clinical Practice · doi:10.1155/ijcp/5582661
Microbiota-derived TMAO links PM 2.5 exposure to cognitive impairment: A gut–liver–brain axisPreprint
Akhlaq, H., Zhong, Y., Du, S., Ma, Z., Cheng, T., Yu, J., Hin, L. C., Formolo, D. A., Lee, P. K. H., Wang, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.24.727565
Atıcı, Y., Eruyar, E., Ökten, Z., Serdar, C. C., SERDAR, M. A., & Yücel, D. (2026) · The Indian Journal of Medical Research · doi:10.25259/ijmr_3392_2025
Do microbiota rhythms influence cognitive performance? - A narrative review
Kapela, M., Barszcz, E., Michno, K., Zielińska, D., Strzelecki, D., & Gawlik-Kotelnicka, O. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1903770
Neuromodulation Techniques in Chronic Cerebral Hypoperfusion: Mechanisms and Therapeutic Advances
Qiao, C., Li, N., Wang, C., Wang, Y., Li, J., Wang, H., Liu, Z., & Qie, S. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71089
Gut microbiota as a modulator of HDAC: insights into Alzheimer’s disease treatment
Verma, E., Mishra, S., Chellammal, H. S. J., Khandige, P. S., & Gasmi, A. (2026) · Pharmacological Reports · doi:10.1007/s43440-026-00897-9
- Authors
- Deng, Y., Zou, J., Hong, Y., Peng, Q., Fu, X., Duan, R., Chen, J., & Chen, X.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing First Hospital (CN)
- Corresponding author
- Duan, Rui
- Chen, Jie
- Chen, Xiangliang
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2022-11-17
- Volume
- 11
- Issue
- 22
- Pages
- 3650
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC9688447
- OpenAlex
- W4309455544
- Cited by
- 48
- References
- 56
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 14 · 2023: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81701064, JQX20007, BK20220196, 2022M711666)
- Medical Science and Technology Program of Nanjing (81701064, JQX20007, BK20220196, 2022M711666)
- Natural Science Foundation of Jiangsu Province (81701064, JQX20007, BK20220196, 2022M711666)
- China Postdoctoral Science Foundation (81701064, JQX20007, BK20220196, 2022M711666)
- Xinghuo Talent Program of Nanjing First Hospital (81701064, JQX20007, BK20220196, 2022M711666)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- trimethylamine N-oxide, vascular dementia, cognitive impairment, SIRT1, hippocampus, oxidative stress, neuroinflammation, apoptosis, NLRP3 inflammasome, synaptic plasticity, bilateral common carotid artery occlusion, gut microbiota metabolites
- MeSH terms
- Animals, Hippocampus, Inflammation, Methylamines, Vascular Diseases, Dementia, Vascular, Rats, Sirtuin 1, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
