Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
Open accessAbstract
Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body of evidence now supports a crucial role for neuronal activity-dependent mRNA translation, which may occur in dendrites for a subset of neuronal mRNAs. Recent work has begun to define the signaling mechanisms coupling synaptic activation to the protein synthesis machinery. The ERK and mTOR signaling pathways have been shown to regulate the activity of the general translational machinery, while the translation of particular classes of mRNAs is additionally controlled by gene-specific mechanisms. Rapid enhancement of the synthesis of a diverse array of neuronal proteins through such mechanisms provides the components necessary for persistent forms of LTP and LTD. These findings have important implications for the synapse specificity and associativity of protein synthesis-dependent changes in synaptic strength.
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The consolidation of memory and long-term potentiation (LTP) require protein synthesis.
“The consolidation of memory and long-term potentiation (LTP) require protein synthesis (1, 2).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [2]
BDNF action was selective on the spines that showed immediate enlargement, which may act as the structural tag for selective trapping of the protein-synthetic machinery and the capture of plasticity proteins for long-term spine-head enlargement.
“BDNF action was selective on the spines that showed immediate enlargement, which may act as the structural tag for selective trapping (26) of the protein-synthetic machinery (11, 27) and the capture of plasticity proteins (2, 28) for long-term spine-head enlargement.”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [2]
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- Authors
- Kelleher, R. J., Govindarajan, A., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tonegawa, Susumu
- ORCID
- Tonegawa, Susumu
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 44
- Issue
- 1
- Pages
- 59-73
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2032057219
- Cited by
- 592
- References
- 9
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 20 · 2023: 15 · 2022: 18 · 2021: 17 · 2020: 21 · 2019: 10 · 2018: 25 · 2017: 23 · 2016: 21 · 2015: 26 · 2014: 38 · 2013: 41 · 2012: 38
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ns002071-05)
- National Institute of Mental Health (P50-MH58880, P50MH058880)
- National Institute of Neurological Disorders and Stroke (R01 NS32925, K08-NS02071, R01NS032925)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic translation, long-term synaptic plasticity, long-term potentiation, long-term depression, ERK signaling, mTOR signaling, transcriptional regulation, memory, protein synthesis, synapse specificity
- MeSH terms
- Animals, Humans, Neuronal Plasticity, Synapses, Time Factors, Protein Biosynthesis
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