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Cited by 46Liver physiology and pathologyMesenchymal stem cell researchTissue Engineering and Regenerative Medicine

Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview

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Pinheiro, Daphne, Dias, Isabelle, Ribeiro Silva, Karina, Stumbo, Ana Carolina, Thole, Alessandra, Cortez, Erika, de Carvalho, Lais, Weiskirchen, Ralf +1 more·2019·Cells
DOI 10.3390/cells8111339PMC PMC6912561
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Abstract

Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating immune cells, endothelial cells, non-parenchymal hepatic stellate cells, and fibroblasts, which become activated and lead to excessive extracellular matrix accumulation. The ongoing development of liver fibrosis results in a clinically silent and progressive loss of hepatocyte function, demanding the constant need for liver transplantation in clinical practice, and motivating the search for other treatments as the chances of obtaining compatible viable livers become scarcer. Although initially cell therapy has emerged as a plausible alternative to organ transplantation, many factors still challenge the establishment of this technique as a main or even additional therapeutic tool. Herein, the authors discuss the most recent advances and point out the corners and some controversies over several protocols and models that have shown promising results as potential candidates for cell therapy for liver fibrosis, presenting the respective mechanisms proposed for liver regeneration in each case.

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  • Human studies of hepatocyte transplantation did not show favorable results regarding liver function, fibrosis, or survival rates.

    “Nevertheless, unlike findings from animal experiments, human studies did not show favorable results regarding liver function, fibrosis, or survival rates [37–39].”

    From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [39]

    Section 2.6 (page not available) says hepatocyte transplantation produced better overall results in animal models than in humans, supporting the comparison. But it also reports several months of disease regression in human recipients and does not establish that human studies showed no favorable results for liver function, fibrosis, or survival rates. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Pinheiro, D., Dias, I., Ribeiro Silva, K., Stumbo, A. C., Thole, A., Cortez, E., de Carvalho, L., Weiskirchen, R., & Carvalho, S.
Affiliations
  • Universidade do Estado do Rio de Janeiro (BR)
  • Laboratory of Stem Cell Research, Histology and Embryology Department, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-170, Brazil
  • Universitätsklinikum Aachen (DE)
Corresponding author
Carvalho, Simone
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2019-10-29
Volume
8
Issue
11
Pages
1339
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells8111339
PMC
PMC6912561
OpenAlex
W2982446972
Cited by
46
References
7
Citations by year
2026: 4 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 5 · 2018: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
Funders
The laboratory of R.W. is supported by the German Research Foundation (SFB/TRR57, projects P13 and Q3) and the Interdisciplinary Centre for Clinical Research (IZKF) within the Faculty of Medicine at the RWTH Aachen University (Project O3 (SFB/TRR57, projects P13 and Q3)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
liver fibrosis, cell therapy, liver regeneration, hepatic stellate cells, extracellular matrix accumulation, hepatocyte regeneration, immune cell activation, fibroblast activation, liver transplantation alternatives, regenerative medicine
MeSH terms
Humans, Liver Cirrhosis, Liver Regeneration, Stem Cells, Liver Failure, Hepatocytes, Endothelial Cells, Cell- and Tissue-Based Therapy

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