Polymeric matrices for mangiferin delivery: Ways to enhance bioavailability and therapeutic effect
Open accessAbstract
Mangiferin, a polyphenol derived from Mangifera indica, exhibits a wide range of pharmacological activities, positioning it as a promising candidate for applications in medicine. Its potential as an alternative to antibiotics is especially significant in agriculture and medicine, addressing the global demand for non-traditional antibacterial agents. However, its poor water solubility and low bioavailability limit its therapeutic use. Polymeric matrices could be one of the potential approaches to solve these problems, enhancing mangiferin’s bioavailability. Each delivery system exhibits unique properties such as controlled release, prolonged action and organ-specific targeting, in an ideal case each directed to specific diseases and administration routes. While promising in vitro and in vivo results highlight their therapeutic potential, challenges remain in the optimization of the matrix formulations for precise applications. Further research is needed to develop these systems and confirm their efficacy in clinical practice.
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Inconsistent reporting of dose-exposure relationships across preclinical studies complicates cross-study comparisons and dose selection for human studies.
“iv) inconsistent reporting of dose-exposure relationships across preclinical studies (170,171). These issues complicate cross-study comparisons and dose selection for human studies.”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [171]
The Abstract and Conclusions and Future Perspectives discuss low bioavailability, formulation challenges, and the need for further in vivo and clinical research. The copy also lists concentrations used in individual studies, but the passages found for dose–exposure relationships do not address inconsistent reporting across preclinical studies, cross-study comparisons, or dose selection for human studies. (LLM, conf=0.76)
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Cites
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Cited by
Sorted by citations
Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
- Authors
- Shaikenov, R. O., Klimshina, V. I., Morozkina, S. N., & Snetkov, P. P.
- Affiliations
- ITMO University (RU)
- Institute of Advanced Data Transfer Systems, ITMO University, Kronverkskiy Prospekt, 49, Bldg. A, Saint-Petersburg 197101, Russia
- Corresponding author
- Shaikenov, Roman O.
- Venue
- The 5th International Electronic Conference on Applied Sciences
- Publisher
- MDPI
- Published
- 2025-06-12
- Pages
- 78
- OpenAlex
- W4411283026
- Cited by
- 2
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 35.77
- Type
- conference paper
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Electronic Conference on Applied Sciences (ASEC) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Science Foundation (24-23-00269)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- mangiferin, polymer matrix, bioavailability enhancement, controlled release, mango, polyphenols, antibacterial agents, drug delivery systems, water solubility
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