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Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.)
Open accessAbstract
Garlic (Allium sativum L.) is a widely consumed spice in the world. Garlic contains diverse bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide, ajoene, and S-allyl-cysteine. Substantial studies have shown that garlic and its bioactive constituents exhibit antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardiovascular protective, anticancer, hepatoprotective, digestive system protective, anti-diabetic, anti-obesity, neuroprotective, and renal protective properties. In this review, the main bioactive compounds and important biological functions of garlic are summarized, highlighting and discussing the relevant mechanisms of actions. Overall, garlic is an excellent natural source of bioactive sulfur-containing compounds and has promising applications in the development of functional foods or nutraceuticals for the prevention and management of certain diseases.
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“Saponins extracted from garlic were reported to scavenge intracellular ROS and protect mouse-derived C2C12 myoblasts towards growth inhibition and H2O2-induced DNA damage [68].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [68]
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“Shang et al. [68] reported that the anticancer mechanisms of garlic extracts were attributed to the inhibition of cell growth and proliferation, regulation of carcinogen metabolism, stimulation of apoptosis, prevention of angiogenesis, invasion, and migration and thus reducing the anticancer agent’s negative effects.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [68]
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“Moreover, Z-ajoene has shown anti-proliferative activities against different types of cancers and it inhibits the growth of human breast cancer cells and glioblastoma multiforme cancer stem cells (GBM CSC) [68].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [68]
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Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats
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Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice
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Anti-inflammatory effect of garlic 14-kDa protein on LPS-stimulated-J774A.1 macrophages
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Fermented garlic extract ameliorates monocrotaline-induced pulmonary hypertension in rats
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Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review
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Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders
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Metadata
- Authors
- Shang, A., Cao, S.-Y., Xu, X.-Y., Gan, R.-Y., Tang, G.-Y., Corke, H., Mavumengwana, V., & Li, H.-B.
- Affiliations
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- South African Medical Research Council (ZA)
- Corresponding author
- Gan, Ren-You
- Li, Hua-Bin
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2019-07-05
- Volume
- 8
- Issue
- 7
- Pages
- 246
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC6678835
- OpenAlex
- W2955644861
- Cited by
- 896
- References
- 166
- Citations by year
- 2026: 94 · 2025: 142 · 2024: 150 · 2023: 156 · 2022: 161 · 2021: 118 · 2020: 64 · 2019: 7
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Funders
- the National Key R&D Program of China (2017YFC1600100)
- the Shanghai Basic and Key Program (18JC1410800)
- the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University (Agri-X2017004)
- the Key Project of Guangdong Provincial Science and Technology Program (2014B020205002)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- garlic, bioactive compounds, allicin, alliin, diallyl sulfide, ajoene, S-allylcysteine, sulfur compounds, antioxidant activity, anti-inflammatory activity, antibacterial activity, antifungal activity, anticancer activity, hepatoprotection, antidiabetic activity, anti-obesity, neuroprotection, renal protection, cardioprotection, functional foods, nutraceuticals
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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