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Chemical Composition, Antioxidant and Enzyme Inhibitory Properties of Different Extracts Obtained from Spent Coffee Ground and Coffee Silverskin
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In a world where an eco-friendlier approach is becoming more and more necessary, it is essential to reduce waste production and to reuse residues of the company’s supply chain. Coffee silverskin (CS) and spent coffee ground (SCG), two by-products of coffee production, are important sources of bioactive compounds and, for this, some authors have proposed their reuse in the nutraceutical, food, and cosmetic sector. However, their potential enzyme inhibitory properties have been poorly investigated. Hence, the objective of the current work was to study the enzymatic inhibitory activities against acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, and tyrosinase of different extracts of CS and SCG. Before these in vitro bioassays, the phytochemical composition of each extract was investigated via colorimetric assays and HPLC-MS/MS analysis. In addition, the antioxidant activities were evaluated by different chemical approaches. SCG extracts contained a higher content of bioactive compounds, notably the SCG EtOH:H2O extract was the richest in caffeine and possessed the highest antioxidant activities. The hydroalcoholic and methanolic extracts were shown to be the most active against all tested enzymes, while the water extracts displayed lower activity. Our results showed a weak correlation between bioactive compounds and enzyme inhibitory effects, proving inhibitory activities likely due to non-phenolic molecules such as alkaloids and terpenoids. Obtained findings could be a starting point to develop novel nutraceuticals from CS and SCG.
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“The above results follow those of Tundis et al. [35] and Zengin et al. [36], where flavonoids, according to the former, and especially apigenin 7-glucoside, showed a potential anti-cholinesterase effect, while the latter showed an enzyme-inhibitory effect for the total methanolic extracts of both SCGs and coffee silverskin.”
From The Valorization of Spent Coffee Ground Extract as a Prospective Insecticidal Agent against Some Main Key Pests of Phaseolus vulgaris in the Laboratory and Field (2022) · cites this paper as Zengin et al. [36]
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Metadata
- Authors
- Zengin, G., Sinan, K. I., Mahomoodally, M. F., Angeloni, S., Mustafa, A. M., Vittori, S., Maggi, F., & Caprioli, G.
- Affiliations
- Department of Biology, Science Faculty, Selcuk University, Campus, Konya, 42130 Konya, Turkey
- Selçuk University (TR)
- Duy Tan University (VN)
- Università di Camerino (IT)
- Corresponding author
- Maggi, Filippo
- ORCID
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2020-06-02
- Volume
- 9
- Issue
- 6
- Pages
- 713
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC7353581
- OpenAlex
- W3033666822
- Cited by
- 122
- References
- 61
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 28 · 2023: 19 · 2022: 18 · 2021: 12 · 2020: 2
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Unicam Scientific Publications (University of Camerino) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- Università degli Studi di Camerino (FPI000051)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Keywords
- spent coffee grounds, coffee silverskin, coffee by-products, antioxidant activity, enzyme inhibition, acetylcholinesterase, butyrylcholinesterase, alpha-amylase, alpha-glucosidase, tyrosinase, caffeine, bioactive compounds, nutraceuticals, waste valorization, phenolic compounds, alkaloids, terpenoids
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