Association Analysis of 14 Candidate Gene Polymorphism with Depression and Stress among Gestational Diabetes Mellitus
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The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.
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Polymorphisms in the 5-HTTLPR gene correlate with cognitive dysfunction in PTSD-affected individuals.
“Similarly, polymorphisms in the 5-HTTLPR gene correlate with cognitive dysfunction in PTSD-affected individuals [33,45,48,49,50].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [33]
Polymorphisms in genes such as EPHX2, OXTR, and NRG1 are associated with depression symptoms.
“Polymorphisms in genes such as EPHX2, OXTR, and NRG1 are associated with depression symptoms, further underscoring the complex interplay between genetics and environment.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [33]
Altered expression of the PPM1F gene in the amygdala and medial prefrontal cortex is linked to PTSD and depression.
“An altered expression of the PPM1F gene in the amygdala and medial prefrontal cortex (mPFC) is linked to PTSD and depression.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [33]
Carrying the short allele of the 5-HTTLPR in high-stress environments increases depression risk.
“For example, carrying the short allele of the 5-HTTLPR in high-stress environments increases depression risk.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [33]
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Association of OXTR polymorphism (rs53576) with depression: a meta-analysis
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The Effect of Depression and Stress Hormones on the Development of Gestational Diabetes Mellitus
Özlüer, A., Onaran, Y., Aydoğan, E., Üçgül, E., Demirci, H., & Yeşilyurt, H. (2025) · Gazi Medical Journal · doi:10.12996/gmj.2025.4413
- Authors
- Lee, K. W., Ching, S. M., Ramachandran, V., Tusimin, M., Mohd Nordin, N., Chong, S. C., & Hoo, F. K.
- Affiliations
- Universiti Putra Malaysia (MY)
- Department of Obstetrics and Gynaecology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia
- Corresponding author
- Ching, Siew Mooi
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2019-11-30
- Volume
- 10
- Issue
- 12
- Pages
- 988
- ISSN
- 2073-4425 (ISSN-L)
- PMC
- PMC6947641
- OpenAlex
- W2990949914
- Cited by
- 14
- References
- 82
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Genes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Funders
- Universiti Putra Malaysia (UPM/700-2/1/GP-IPS/2018/9593800, UPM/800-3/3/1/GPB/2018/9659600, UPM/SPS/GS48750)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- gestational diabetes mellitus, depression, anxiety, stress, candidate gene polymorphisms, single nucleotide polymorphisms, EPHX2, oxytocin receptor, neuregulin-1, genetic susceptibility
- MeSH terms
- Adult, Anxiety, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Malaysia, Pregnancy, Diabetes, Gestational, Polymorphism, Single Nucleotide
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