Cited by 14Maternal Mental Health During Pregnancy and PostpartumGenetic Associations and EpidemiologyGestational Diabetes Research and Management

Association Analysis of 14 Candidate Gene Polymorphism with Depression and Stress among Gestational Diabetes Mellitus

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Lee, Kai Wei, Ching, Siew Mooi, Ramachandran, Vasudevan, Tusimin, Maiza, Mohd Nordin, Noraihan, Chong, Seng Choi, Hoo, Fan Kee·2019·Genes

Abstract

The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.

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Authors
Lee, K. W., Ching, S. M., Ramachandran, V., Tusimin, M., Mohd Nordin, N., Chong, S. C., & Hoo, F. K.
Affiliations
  • Universiti Putra Malaysia (MY)
  • Department of Obstetrics and Gynaecology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia
Corresponding author
Ching, Siew Mooi
Venue
Genes
Publisher
MDPI AG
Published
2019-11-30
Volume
10
Issue
12
Pages
988
ISSN
2073-4425 (ISSN-L)
OpenAlex
W2990949914
Cited by
14
References
82
Citations by year
2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1
FWCI
1.38
Type
journal article
Language
en
Open access
Locations
  • Genes (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
Funders
Universiti Putra Malaysia (UPM/700-2/1/GP-IPS/2018/9593800, UPM/800-3/3/1/GPB/2018/9659600, UPM/SPS/GS48750)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
gestational diabetes mellitus, depression, anxiety, stress, candidate gene polymorphisms, single nucleotide polymorphisms, EPHX2, oxytocin receptor, neuregulin-1, genetic susceptibility
MeSH terms
Adult, Anxiety, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Malaysia, Pregnancy, Diabetes, Gestational, Polymorphism, Single Nucleotide

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