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BMI and BMD: The Potential Interplay between Obesity and Bone Fragility
Open accessAbstract
Recent evidence demonstrating an increased fracture risk among obese individuals suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm of fat mass playing a protective role towards bone health. White adipose tissue, far from being a mere energy depot, is a dynamic tissue actively implicated in metabolic reactions, and in fact secretes several hormones called adipokines and inflammatory factors that may in turn promote bone resorption. More specifically, Visceral Adipose Tissue (VAT) may potentially prove detrimental. It is widely acknowledged that obesity is positively associated to many chronic disorders such as metabolic syndrome, dyslipidemia and type 2 diabetes, conditions that could themselves affect bone health. Although aging is largely known to decrease bone strength, little is yet known on the mechanisms via which obesity and its comorbidities may contribute to such damage. Given the exponentially growing obesity rate in recent years and the increased life expectancy of western countries it appears of utmost importance to timely focus on this topic.
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Pop, L. C., Sukumar, D., Tomaino, K., Schlussel, Y., Schneider, S. H., Gordon, C. L., Wang, X., & Shapses, S. A. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088534 · Cited by 47
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Flagged first, then by citations
Research works printed but not linked: 1
- Bone Health and Osteoporosis: A Report of the Surgeon General, Available online: http://www.ncbi.nlm.nih.gov/pubmed/?term=20945569.
Cited by
Sorted by citations
Obesity and Bone: A Complex Relationship
Rinonapoli, G., Pace, V., Ruggiero, C., Ceccarini, P., Bisaccia, M., Meccariello, L., & Caraffa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413662 · Cited by 280
Genome-wide association study of medication-use and associated disease in the UK Biobank
Wu, Y., Byrne, E. M., Zheng, Z., Kemper, K. E., Yengo, L., Mallett, A. J., Yang, J., Visscher, P. M., & Wray, N. R. (2019) · Nature Communications · doi:10.1038/s41467-019-09572-5 · Cited by 243
The advances in nanomedicine for bone and cartilage repair
Qiao, K., Xu, L., Tang, J., Wang, Q., Lim, K. S., Hooper, G. J., Woodfield, T. B. F., Liu, G., Tian, K., Zhang, W., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01342-8 · Cited by 135
Gandham, A., Mesinovic, J., Jansons, P., Zengin, A., Bonham, M. P., Ebeling, P. R., & Scott, D. S. (2021) · Obesity Reviews · doi:10.1111/obr.13187 · Cited by 132
Obesity and Bone Health: A Complex Relationship
Piñar-Gutiérrez, A., García‐Fontana, C., García-Fontana, B., & Muñoz‐Torres, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158303 · Cited by 126
Metadata
- Authors
- Palermo, A., Tuccinardi, D., Defeudis, G., Watanabe, M., D’Onofrio, L., Lauria Pantano, A., Napoli, N., Pozzilli, P., & Manfrini, S.
- Affiliations
- Università Campus Bio-Medico (IT)
- Sapienza University of Rome (IT)
- Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
- Corresponding author
- Palermo, Andrea
- ORCID
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2016-05-28
- Volume
- 13
- Issue
- 6
- Pages
- 544
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC4924001
- OpenAlex
- W2400849275
- Cited by
- 197
- References
- 239
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 23 · 2023: 17 · 2022: 27 · 2021: 17 · 2020: 30 · 2019: 20 · 2018: 20 · 2017: 8 · 2016: 3
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- obesity, bone fragility, body mass index, bone mineral density, fracture risk, visceral adipose tissue, adipokines, bone resorption, metabolic syndrome, type 2 diabetes, dyslipidemia, aging, bone health
- MeSH terms
- Adipose Tissue, Bone Resorption, Humans, Obesity, Bone Density, Body Mass Index, Inflammation Mediators, Metabolic Syndrome, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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