Cited by 130Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

Effects of 16 Weeks of Resistance Training on Muscle Quality and Muscle Growth Factors in Older Adult Women with Sarcopenia: A Randomized Controlled Trial

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Seo, Myong-Won, Jung, Sung-Woo, Kim, Sung-Woo, Lee, Jung-Min, Jung, Hyun Chul, Song, Jong-Kook·2021·International Journal of Environmental Research and Public Health

Abstract

This study examined the effects of resistance training on muscle quality, muscle growth factors, and functional fitness in older adult women with sarcopenia. Twenty-two older adult women aged over 65 with sarcopenia were randomly assigned to either resistance training (RT, n = 12) or non-exercise control group (CG, n = 10). The body weight-based and elastic band RT were performed three times a week, 60 min per session, for 16 weeks. Body composition and thigh muscle quality were estimated by dual-energy X-ray absorptiometry (DEXA) and computed tomography (CT), respectively. The muscle growth factors, including growth differentiation factor-8 (GDF-8), growth differentiation factor-15 (GDF-15), activin A, and follistatin, were analyzed via blood samples. Statistical analyses were performed using repeated measures multivariate analysis of variance (MANOVA), analysis of variance (ANOVA), and effect size (i.e., cohen’s d, partial eta square), and the significance level was set at 0.05. The RT group improved their functional fitness, grip strength, gait speed, and isometric muscle strength (p < 0.01, d > 0.99; large), while these variables did not change in the CG. An increase in intramuscular fat was only observed in the CG (p < 0.01, 1.06; large). Muscle growth factors such as follistatin were significantly increased in the RT (p < 0.05, 0.81; large), but other variables did not change following resistance training. Sixteen weeks of resistance training improved functional fitness and prevented age-related increases in intramuscular fat in the thigh area. However, there were only some changes in muscle growth factors, such as follistatin, suggesting that the effectiveness of resistance training on muscle growth factors is limited. Body weight-based and elastic band resistance training is an alternative training method for sarcopenia to minimize the age-related adverse effects on muscle function and quality.

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Crossref · 10.3390/ijerph18136762

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  • In humans and mouse models, acute and chronic exercise increase liver-secreted follistatin, which has been reported to antagonize myostatin.

    “in both humans97–99 and mouse models100, acute exercise97,100 and chronic exercise98 increase liver-secreted follistatin, which has been reported to antagonize the effects of myostatin99.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [98]

  • In humans, both acute and chronic exercise increase circulating follistatin.

    “In humans, both acute exercise97 and chronic exercise98 increase circulating levels of follistatin.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [98]

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Authors
Seo, M.-W., Jung, S.-W., Kim, S.-W., Lee, J.-M., Jung, H. C., & Song, J.-K.
Affiliations
Kyung Hee University (KR)
Corresponding author
Song, Jong-Kook
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2021-06-23
Volume
18
Issue
13
Pages
6762
ISSN
1660-4601 (ISSN-L)
OpenAlex
W3176042879
Cited by
130
References
41
Citations by year
2026: 29 · 2025: 38 · 2024: 25 · 2023: 25 · 2022: 12 · 2021: 1
FWCI
9.90
Type
journal article
Language
en
Open access
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2018S1A5A2A03035186)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
resistance training, sarcopenia, older women, muscle quality, functional fitness, intramuscular fat, thigh muscle, follistatin, growth differentiation factor 15, activin A, myostatin, resistance band training, grip strength, walking speed, muscle strength
MeSH terms
Aged, Body Composition, Female, Humans, Exercise, Muscle, Skeletal, Muscle Strength, Resistance Training, Sarcopenia

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