The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Melatonin: Buffering the Immune System
Open accessAbstract
Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.
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Cites
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Interleukin-17 and Type 17 Helper T Cells
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Melatonin—A pleiotropic, orchestrating regulator molecule
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The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
Slominski, A., Wortsman, J., & Tobin, D. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2079rev · Cited by 402
Melatonin, human aging, and age-related diseases
Karasek, M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.012 · Cited by 380
Do plasma melatonin concentrations decline with age?
Zeitzer, J. M., Daniels, J. E., Duffy, J. F., Klerman, E. B., Shanahan, T. L., Dijk, D.-J., & Czeisler, C. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00266-1 · Cited by 239
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Self-citationConceptual development of the immune system as a sixth sense
Blalock, J. E., & Smith, E. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.004 · Cited by 153
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Cited by
Functions of melatonin in plants: a review
Arnao, M. B., & Hernández‐Ruiz, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12253 · Cited by 889
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738
Melatonin: plant growth regulator and/or biostimulator during stress?
Arnao, M. B., & Hernández-Ruiz, J. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2014.07.006 · Cited by 674
Melatonin and inflammation-Story of a double-edged blade
Hardeland, R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12525 · Cited by 455
Update on melatonin receptors: IUPHAR Review 20
Jockers, R., Delagrange, P., Dubocovich, M. L., Markus, R. P., Renault, N., Tosini, G., Cecon, E., & Zlotos, D. P. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13536 · Cited by 422
Metadata
- Authors
- Carrillo-Vico, A., Lardone, P., Álvarez-Sánchez, N., Rodríguez-Rodríguez, A., & Guerrero, J.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-04-22
- Volume
- 14
- Issue
- 4
- Pages
- 8638-8683
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W1964187078
- Cited by
- 740
- References
- 9
- FWCI
- 18.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Carrillo-Vico, A., Lardone, P., Álvarez-Sánchez, N., Rodríguez-Rodríguez, A., & Guerrero, J. (2013). Melatonin: Buffering the Immune System. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms14048638
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
