Cited by 222Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressNutritional Studies and Diet

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Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

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Moser, Melissa, Chun, Ock·2016·International Journal of Molecular Sciences

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Abstract

Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency. The objective of this review is to systematically review the findings of existing epidemiologic research on vitamin C and its potential role in cardiovascular disease (CVD). It is well established that vitamin C inhibits oxidation of LDL-protein, thereby reducing atherosclerosis, but the cardiovascular outcomes related to this action and other actions of vitamin C are not fully understood. Randomized controlled trials as well as observational cohort studies have investigated this topic with varying results. Vitamin C has been linked in some work to improvements in lipid profiles, arterial stiffness, and endothelial function. However, other studies have failed to confirm these results, and observational cohort studies are varied in their findings on the vitamin’s effect on CVD risk and mortality. Overall, current research suggests that vitamin C deficiency is associated with a higher risk of mortality from CVD and that vitamin C may slightly improve endothelial function and lipid profiles in some groups, especially those with low plasma vitamin C levels. However, the current literature provides little support for the widespread use of vitamin C supplementation to reduce CVD risk or mortality.

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Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345
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Joshipura, K. J., Hu, F. B., Manson, J. E., Stampfer, M. J., Rimm, E. B., Speizer, F. E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-12-200106190-00010 · Cited by 1,396
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Authors: Moser, M., & Chun, O.
Affiliations: Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
University of Connecticut (US)
Corresponding author: Chun, Ock
ORCID: Moser, Melissa
Chun, Ock
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2016-08-12
Volume: 17
Issue: 8
Pages: 1328
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms17081328
PMC: PMC5000725
OpenAlex: W2517706500
Cited by: 222
References: 34
Citations by year: 2026: 6 · 2025: 14 · 2024: 21 · 2023: 24 · 2022: 29 · 2021: 38 · 2020: 32 · 2019: 22 · 2018: 21 · 2017: 11 · 2016: 3
FWCI: 2.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: vitamin C, cardiovascular disease, scurvy, plasma vitamin C concentration, LDL oxidation, atherosclerosis, endothelial function, arterial stiffness, lipid profile, cardiovascular mortality, vitamin C supplementation
MeSH terms: Antioxidants, Ascorbic Acid, Cardiovascular Diseases, Humans, Oxidation-Reduction, Epidemiologic Studies, Dietary Supplements

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Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies

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