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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer

Carbone, Carmine, Piro, Geny, Merz, Valeria, Simionato, Francesca, Santoro, Raffaela, Zecchetto, Camilla, Tortora, Giampaolo, Melisi, Davide·2018·International Journal of Molecular Sciences
DOI 10.3390/ijms19020431PMC PMC5855653
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Abstract

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last decade, emerging evidences supported the autocrine and paracrine activity of the members of the Angiopoietin-like (ANGPTL) protein family in angiogenesis, inflammation and in the regulation of different steps of carcinogenesis and metastasis development. Thus, ANGPTL proteins become attractive either as prognostic or predictive biomarkers, or as novel target for cancer treatment. Here, we outline the current knowledge about the functions of the ANGPTL proteins in angiogenesis, cancer progression and metastasis. Moreover, we discuss the most recent evidences sustaining their role as prognostic or predictive biomarkers for cancer therapy. Although the role of ANGPTL proteins in cancer has not been fully elucidated, increasing evidence suggest their key effects in the proliferative and invasive properties of cancer cells. Moreover, given the common overexpression of ANGPTL proteins in several aggressive solid tumors, and their role in tumor cells and cells of the tumor microenvironment, the field of research about ANGPTL proteins network may highlight new potential targets for the development of future therapeutic strategies.

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Figure 1 Schematic representation of ANGPTL proteins structure. The ANGPTL family has three conserved domains; a N-terminal signal peptide, a coiled coil domain and a fibrinogen like domain.
Figure 1 Schematic representation of ANGPTL proteins structure. The ANGPTL family has three conserved domains; a N-terminal signal peptide, a coiled coil domain and a fibrinogen like domain.CC BY · PubMed Central

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Cites

Research works printed but not linked: 139

  1. Jones, 2001, Tie receptors: New modulators of angiogenic and lymphangiogenic responses, Nat. Rev. Mol. Cell Biol., 2, 257, 10.1038/35067005 · DOI
  2. Oike, 2003, Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration, Proc. Natl. Acad. Sci. USA, 100, 9494, 10.1073/pnas.1531901100 · DOI
  3. Ito, 2003, Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4, Cancer Res., 63, 6651
  4. Deng, 2014, A motif in LILRB2 critical for Angptl2 binding and activation, Blood, 124, 924, 10.1182/blood-2014-01-549162 · DOI
  5. Zheng, 2012, Inhibitory receptors bind angptls and support blood stem cells and leukaemia development, Nature, 485, 656, 10.1038/nature11095 · DOI
  6. Dhanabal, 2002, Angioarrestin: An antiangiogenic protein with tumor-inhibiting properties, Cancer Res., 62, 3834
  7. Kim, 1999, Molecular cloning, expression, and characterization of angiopoietin-related protein. Angiopoietin-related protein induces endothelial cell sprouting, J. Biol. Chem., 274, 26523, 10.1074/jbc.274.37.26523 · DOI
  8. Endo, 2014, Serum angptl2 levels reflect clinical features of breast cancer patients: Implications for the pathogenesis of breast cancer metastasis, Int. J. Biol. Markers, 29, e239, 10.5301/jbm.5000080 · DOI
  9. Masuda, 2015, Angptl2 increases bone metastasis of breast cancer cells through enhancing cxcr4 signaling, Sci. Rep., 5, 9170, 10.1038/srep09170 · DOI
  10. Yang, 2015, GDC-0152 attenuates the malignant progression of osteosarcoma promoted by Angptl2 via PI3k/AKT but not p38MAPK signaling pathway, Int. J. Oncol., 46, 1651, 10.3892/ijo.2015.2872 · DOI
  11. Endo, 2012, Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis, Cancer Res., 72, 1784, 10.1158/0008-5472.CAN-11-3878 · DOI
  12. Carbone, 2015, An angiopoietin-like protein 2 autocrine signaling promotes EMT during pancreatic ductal carcinogenesis, Oncotarget, 6, 13822, 10.18632/oncotarget.2635 · DOI
  13. Chatterjee, 2013, Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis, Physiol. Genom., 45, 697, 10.1152/physiolgenomics.00042.2013 · DOI
  14. Chen, 2016, Angiopoietin-like protein 1 antagonizes met receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma, Hepatology, 64, 1637, 10.1002/hep.28773 · DOI
  15. Dhanabal, 2005, Angioarrestin: A unique angiopoietin-related protein with anti-angiogenic properties, Biochem. Biophys. Res. Commun., 333, 308, 10.1016/j.bbrc.2005.05.134 · DOI
  16. Hansen, 2010, Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase tie2 are differentially regulated at the endothelial cell surface, Cell Signal., 22, 527, 10.1016/j.cellsig.2009.11.007 · DOI
  17. Tabata, 2009, Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance, Cell Metab., 10, 178, 10.1016/j.cmet.2009.08.003 · DOI
  18. Lee, 2013, Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism, Biochem. Biophys. Res. Commun., 430, 981, 10.1016/j.bbrc.2012.11.127 · DOI
  19. Richardson, 2014, Angiopoietin-like protein 2 regulates endothelial colony forming cell vasculogenesis, Angiogenesis, 17, 675, 10.1007/s10456-014-9423-8 · DOI
  20. Oike, 2009, Angiopoietin-like proteins—Potential therapeutic targets for metabolic syndrome and cardiovascular disease, Circ. J., 73, 2192, 10.1253/circj.CJ-09-0710 · DOI
  21. Farhat, 2013, Angiopoietin-like 2 promotes atherogenesis in mice, J. Am. Heart Assoc., 2, e000201, 10.1161/JAHA.113.000201 · DOI
  22. Tian, 2013, Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury, J. Mol. Cell. Cardiol., 57, 1, 10.1016/j.yjmcc.2013.01.004 · DOI
  23. Ide, 2015, Angiopoietin-like protein 2 acts as a novel biomarker for diagnosis and prognosis in patients with esophageal cancer, Ann. Surg. Oncol., 22, 2585, 10.1245/s10434-014-4315-0 · DOI
  24. Camenisch, 2002, ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo, J. Biol. Chem., 277, 17281, 10.1074/jbc.M109768200 · DOI
  25. Tan, 2012, Emerging roles of angiopoietin-like 4 in human cancer, Mol. Cancer Res. MCR, 10, 677, 10.1158/1541-7786.MCR-11-0519 · DOI
  26. Cazes, 2006, Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton, Circ. Res., 99, 1207, 10.1161/01.RES.0000250758.63358.91 · DOI
  27. Galaup, 2006, Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness, Proc. Natl. Acad. Sci. USA, 103, 18721, 10.1073/pnas.0609025103 · DOI
  28. Shibata, 2010, Clinicopathological significance of angiopoietin-like protein 4 expression in oesophageal squamous cell carcinoma, J. Clin. Pathol., 63, 1054, 10.1136/jcp.2010.078600 · DOI
  29. Goh, 2010, Angiopoietin-Like 4 Interacts with Integrins β1 and β5 to Modulate Keratinocyte Migration, Am. J. Pathol., 177, 2791, 10.2353/ajpath.2010.100129 · DOI
  30. Padua, 2008, Tgfbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4, Cell, 133, 66, 10.1016/j.cell.2008.01.046 · DOI
  31. Zhu, 2011, Angiopoietin-like 4 protein elevates the prosurvival intracellular O2−:H2O2 ratio and confers anoikis resistance to tumors, Cancer Cell, 19, 401, 10.1016/j.ccr.2011.01.018 · DOI
  32. Hermann, 2005, Angiopoietin-like-4 is a potential angiogenic mediator in arthritis, Clin. Immunol., 115, 93, 10.1016/j.clim.2004.12.002 · DOI
  33. Tan, 2017, Angptl4 t266m variant is associated with reduced cancer invasiveness, Biochim. Biophys. Acta, 1864, 1525, 10.1016/j.bbamcr.2017.06.010 · DOI
  34. Ifon, 2005, U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3, Cancer Cell Int., 5, 19, 10.1186/1475-2867-5-19 · DOI
  35. Costa, R.A., Cardoso, J.C., and Power, D.M. (2017). Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration. BMC Evol. Biol., 17. · DOI
  36. Zeng, 2003, Identification of a novel human angiopoietin-like gene expressed mainly in heart, J. Hum. Genet., 48, 159, 10.1007/s100380300025 · DOI
  37. Oike, 2005, Angiopoietin-related growth factor antagonizes obesity and insulin resistance, Nat. Med., 11, 400, 10.1038/nm1214 · DOI · Paper page
  38. Tanigawa, 2016, Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis, Sci. Rep., 6, 34690, 10.1038/srep34690 · DOI
  39. Parri, 2014, Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer, Angiogenesis, 17, 881, 10.1007/s10456-014-9435-4 · DOI
  40. Tseng, 2014, Emerging regulation and function of betatrophin, Int. J. Mol. Sci., 15, 23640, 10.3390/ijms151223640 · DOI
  41. Abu-Farha, M., Sriraman, D., Cherian, P., AlKhairi, I., Elkum, N., Behbehani, K., and Abubaker, J. (2016). Circulating angptl8/betatrophin is increased in obesity and reduced after exercise training. PLoS ONE, 11. · DOI
  42. Dong, 2004, Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method, Int. J. Cancer, 112, 239, 10.1002/ijc.20363 · DOI
  43. Ng, 2014, Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma, Mol. Cancer, 13, 196, 10.1186/1476-4598-13-196 · DOI
  44. Kubota, 2005, Cooperative interaction of angiopoietin-like proteins 1 and 2 in zebrafish vascular development, Proc. Natl. Acad. Sci. USA, 102, 13502, 10.1073/pnas.0501902102 · DOI
  45. Arca, 2013, The angiopoietin-like protein 3: A hepatokine with expanding role in metabolism, Curr. Opin. Lipidol., 24, 313, 10.1097/MOL.0b013e3283630cf0 · DOI
  46. Hassan, 2017, Angplt3: A novel modulator of lipid metabolism, Glob. Cardiol. Sci. Pract., 2017, e201706
  47. Shimizugawa, 2002, Angptl3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase, J. Biol. Chem., 277, 33742, 10.1074/jbc.M203215200 · DOI · Paper page
  48. Mehta, 2014, Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits, Arterioscler. Thromb. Vasc. Biol., 34, 1057, 10.1161/ATVBAHA.113.302802 · DOI
  49. Ono, 2003, Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): Angptl3 is cleaved and activated in vivo, J. Biol. Chem., 278, 41804, 10.1074/jbc.M302861200 · DOI · Paper page
  50. Farahbakhshian, E., Verstegen, M.M., Visser, T.P., Kheradmandkia, S., Geerts, D., Arshad, S., Riaz, N., Grosveld, F., van Til, N.P., and Meijerink, J.P. (2014). Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells. PLoS ONE, 9. · DOI
  51. Lee, 2014, Angiopoietin-like 3 regulates hepatocyte proliferation and lipid metabolism in zebrafish, Biochem. Biophys. Res. Commun., 446, 1237, 10.1016/j.bbrc.2014.03.099 · DOI
  52. McQueen, 2017, The c-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure, J. Biol. Chem., 292, 16122, 10.1074/jbc.M117.803973 · DOI · Paper page
  53. Zhu, 2012, Angiopoietin-like 4: A decade of research, Biosci. Rep., 32, 211, 10.1042/BSR20110102 · DOI
  54. Mandard, 2006, The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity, J. Biol. Chem., 281, 934, 10.1074/jbc.M506519200 · DOI · Paper page
  55. Ruge, 2012, Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus, Metabolism, 61, 652, 10.1016/j.metabol.2011.09.014 · DOI
  56. Jonker, 2013, Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes, Am. J. Clin. Nutr., 97, 255, 10.3945/ajcn.112.043687 · DOI
  57. Chong, 2014, Angiopoietin-like 4 stimulates stat3-mediated inos expression and enhances angiogenesis to accelerate wound healing in diabetic mice, Mol. Ther., 22, 1593, 10.1038/mt.2014.102 · DOI
  58. Lei, 2011, Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity, J. Biol. Chem., 286, 15747, 10.1074/jbc.M110.217638 · DOI · Paper page
  59. Huang, 2012, Mechanisms involved in biological behavior changes associated with angptl4 expression in colon cancer cell lines, Oncol. Rep., 27, 1541
  60. Huang, 2011, Angptl4 modulates vascular junction integrity by integrin signaling and disruption of intercellular ve-cadherin and claudin-5 clusters, Blood, 118, 3990, 10.1182/blood-2011-01-328716 · DOI
  61. Xu, 2015, Angiopoietin-like 4: A double-edged sword in atherosclerosis and ischemic stroke?, Exp. Neurol., 272, 61, 10.1016/j.expneurol.2015.05.020 · DOI
  62. Hattori, 2014, Angptl4 is a secreted tumor suppressor that inhibits angiogenesis, Oncogene, 33, 2273, 10.1038/onc.2013.174 · DOI
  63. Xin, 1999, Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo, J. Biol. Chem., 274, 9116, 10.1074/jbc.274.13.9116 · DOI
  64. Listi, 2017, Potential role of ANGPTL4 in the cross talk between metabolism and cancer through ppar signaling pathway, PPAR Res., 2017, 8187235
  65. Amy, 2003, Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma, Am. J. Pathol., 162, 1521, 10.1016/S0002-9440(10)64285-X · DOI
  66. Perdiguero, 2011, Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice, J. Biol. Chem., 286, 36841, 10.1074/jbc.M111.220061 · DOI
  67. Okazaki, 2012, Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet b, J. Dermatol., 39, 366, 10.1111/j.1346-8138.2011.01396.x · DOI
  68. Zhang, 2006, Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with rgd-binding integrins, Biochem. Biophys. Res. Commun., 347, 100, 10.1016/j.bbrc.2006.06.053 · DOI
  69. Sharma, 2017, Correlation of long-term glycemic control as measured by glycated hemoglobin with serum angiopoietin-like 6 protein levels in type 2 diabetes mellitus patients, Indian J. Pharmacol., 49, 250, 10.4103/ijp.IJP_261_16 · DOI
  70. Namkung, 2011, Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome, Metabolism, 60, 564, 10.1016/j.metabol.2010.05.013 · DOI
  71. Katoh, 2006, Comparative integromics on angiopoietin family members, Int. J. Mol. Med., 17, 1145
  72. Peek, 2002, The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea, J. Biol. Chem., 277, 686, 10.1074/jbc.M105746200 · DOI
  73. Toyono, T., Usui, T., Yokoo, S., Taketani, Y., Nakagawa, S., Kuroda, M., Yamagami, S., and Amano, S. (2015). Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea. PLoS ONE, 10. · DOI
  74. Comes, 2011, Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: Implications for glaucoma, Genes Cells Devoted Mol. Cell. Mech., 16, 243, 10.1111/j.1365-2443.2010.01483.x · DOI
  75. Xiao, 2015, Loss of angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells, J. Hematol. Oncol., 8, 7, 10.1186/s13045-014-0102-4 · DOI
  76. Quagliarini, 2012, Atypical angiopoietin-like protein that regulates ANGPTL3, Proc. Natl. Acad. Sci. USA, 109, 19751, 10.1073/pnas.1217552109 · DOI · Paper page
  77. Yi, 2013, Betatrophin: A hormone that controls pancreatic beta cell proliferation, Cell, 153, 747, 10.1016/j.cell.2013.04.008 · DOI · Paper page
  78. Cox, A.R., Barrandon, O., Cai, E.P., Rios, J.S., Chavez, J., Bonnyman, C.W., Lam, C.J., Yi, P., Melton, D.A., and Kushner, J.A. (2016). Resolving discrepant findings on ANGPTL8 in β-cell proliferation: A collaborative approach to resolving the betatrophin controversy. PLoS ONE, 11. · DOI
  79. Aoi, 2014, Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress, Mol. Cancer Res., 12, 239, 10.1158/1541-7786.MCR-13-0336 · DOI
  80. Aoi, 2011, Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis, Cancer Res., 71, 7502, 10.1158/0008-5472.CAN-11-1758 · DOI
  81. Kuo, 2013, Angiopoietin-like protein 1 suppresses slug to inhibit cancer cell motility, J. Clin. Investig., 123, 1082, 10.1172/JCI64044 · DOI
  82. Yan, 2017, ANGPTL1 Interacts with integrin α1β1 to suppress HCC angiogenesis and metastasis by inhibiting JAK2/STAT3 signaling, Cancer Res., 77, 5831, 10.1158/0008-5472.CAN-17-0579 · DOI
  83. Thorin, 2014, Angiopoietin-like-2: A multifaceted protein with physiological and pathophysiological properties, Expert Rev. Mol. Med., 16, e17, 10.1017/erm.2014.19 · DOI
  84. Kadomatsu, 2014, Diverse roles of angptl2 in physiology and pathophysiology, Trends Endocrinol. Metab., 25, 245, 10.1016/j.tem.2014.03.012 · DOI
  85. Okada, 2010, Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis, Am. J. Pathol., 176, 2309, 10.2353/ajpath.2010.090865 · DOI
  86. Horio, 2014, Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression, Arterioscler. Thromb. Vasc. Biol., 34, 790, 10.1161/ATVBAHA.113.303116 · DOI
  87. Sharp, 1989, Regulation of chicken alpha and beta actin genes and their hybrids inserted into myogenic mouse cells, Gene, 80, 293, 10.1016/0378-1119(89)90293-X · DOI
  88. Odagiri, 2014, The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases, Sci. Signal., 7, ra7, 10.1126/scisignal.2004612 · DOI
  89. Broxmeyer, 2012, Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors, Blood Cells Mol. Dis., 48, 25, 10.1016/j.bcmd.2011.09.004 · DOI
  90. Liu, 2015, Angptl2/lilrb2 signaling promotes the propagation of lung cancer cells, Oncotarget, 6, 21004, 10.18632/oncotarget.4217 · DOI
  91. Carbone, 2017, Homeobox B9 mediates resistance to anti-VEGF therapy in colorectal cancer patients, Clin. Cancer Res., 23, 4312, 10.1158/1078-0432.CCR-16-3153 · DOI
  92. Yoshinaga, 2015, Angiopoietin-like protein 2 is a potential biomarker for gastric cancer, Mol. Med. Rep., 11, 2653, 10.3892/mmr.2014.3040 · DOI
  93. Sheng, 2016, ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior, World J. Gastroenterol., 22, 10364, 10.3748/wjg.v22.i47.10364 · DOI
  94. Yoshinaga, 2015, Angiopoietin-like protein 2 as a potential biomarker for colorectal cancer, Mol. Clin. Oncol., 3, 1080, 10.3892/mco.2015.577 · DOI
  95. Toiyama, 2015, Serum angiopoietin-like protein 2 improves preoperative detection of lymph node metastasis in colorectal cancer, Anticancer Res., 35, 2849
  96. Horiguchi, 2014, Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling, Cancer Sci., 105, 1550, 10.1111/cas.12554 · DOI
  97. Melisi, 2014, Pancreatic cancer: Systemic combination therapies for a heterogeneous disease, Curr. Pharm. Des., 20, 6660, 10.2174/1381612820666140826154327 · DOI
  98. Vaccaro, 2011, Emerging pathways and future targets for the molecular therapy of pancreatic cancer, Expert Opin. Ther. Targets, 15, 1183, 10.1517/14728222.2011.607438 · DOI
  99. Tamburrino, 2013, Mechanisms of resistance to chemotherapeutic and anti-angiogenic drugs as novel targets for pancreatic cancer therapy, Front. Pharmacol., 4, 56, 10.3389/fphar.2013.00056 · DOI
  100. Carbone, 2011, Anti-vegf treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype, Clin. Cancer Res., 17, 5822, 10.1158/1078-0432.CCR-11-1185 · DOI
  101. Gaianigo, N., Melisi, D., and Carbone, C. (2017). Emt and treatment resistance in pancreatic cancer. Cancers, 9. · DOI
  102. Melisi, 2013, Rationale and clinical use of multitargeting anticancer agents, Curr. Opin. Pharmacol., 13, 536, 10.1016/j.coph.2013.06.012 · DOI
  103. Gao, 2015, ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma, J. Gastroenterol. Hepatol., 30, 396, 10.1111/jgh.12702 · DOI
  104. Sasaki, 2012, Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer, Oncol. Lett., 4, 1325, 10.3892/ol.2012.924 · DOI
  105. Kikuchi, 2008, Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer, Cancer Res., 68, 5067, 10.1158/0008-5472.CAN-08-0062 · DOI
  106. Sato, 2015, Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells, Oncol. Rep., 33, 58, 10.3892/or.2014.3586 · DOI
  107. Huang, C.L., Wu, Y.W., Wu, C.C., Hwang, J.J., and Yang, W.S. (2015). Serum angiopoietin-like protein 2 concentrations are independently associated with heart failure. PLoS ONE, 10. · DOI
  108. Koyama, 2015, ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer, Cancer Med., 4, 759, 10.1002/cam4.418 · DOI
  109. Wang, 2016, Clinical significance of angiopoietin-like protein 3 expression in patients with glioblastoma, Neoplasma, 63, 93, 10.4149/neo_2016_011 · DOI
  110. Zhu, 2015, Angiopoietin-like protein 3 is an indicator of prognosis in esophageal cancer patients, Int. J. Clin. Exp. Med., 8, 16101
  111. Yu, 2011, Effects of angptl3 antisense oligodeoxynucleotides transfection on the cell growths and invasion of human hepatocellular carcinoma cells, Hepato-Gastroenterology, 58, 1742
  112. Owzar, 2015, Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma, Gynecol. Oncol., 139, 23, 10.1016/j.ygyno.2015.08.001 · DOI
  113. Goh, 2010, Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing, J. Biol. Chem., 285, 32999, 10.1074/jbc.M110.108175 · DOI
  114. Bluher, 2015, Distinct roles of angiopoietin-like 4 in the regulation of central and peripheral lipid metabolism?, Mol. Metab., 4, 79, 10.1016/j.molmet.2014.12.003 · DOI
  115. Nakayama, 2010, Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion, Oncol. Rep., 24, 599, 10.3892/or_00000897 · DOI
  116. Nakayama, 2011, Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis, Oncol. Rep., 25, 929, 10.3892/or.2011.1176 · DOI
  117. Teo, 2017, Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression, Oncogene, 36, 6408, 10.1038/onc.2017.244 · DOI
  118. Kirsch, 2017, Angiopoietin-like 4 is a wnt signaling antagonist that promotes LRP6 turnover, Dev. Cell, 43, 71, 10.1016/j.devcel.2017.09.011 · DOI
  119. Yang, 2008, Suppression of the raf/mek/erk signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4, Arterioscler. Thromb. Vasc. Biol., 28, 835, 10.1161/ATVBAHA.107.157776 · DOI
  120. Chomel, 2009, Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity, FASEB J., 23, 940, 10.1096/fj.08-115170 · DOI
  121. Kim, 2011, ANGPTL4 induction by prostaglandin e2 under hypoxic conditions promotes colorectal cancer progression, Cancer Res., 71, 7010, 10.1158/0008-5472.CAN-11-1262 · DOI
  122. Huang, 2016, The downregulation of angptl4 inhibits the migration and proliferation of tongue squamous cell carcinoma, Arch. Oral Biol., 71, 144, 10.1016/j.archoralbio.2016.07.011 · DOI
  123. Tanaka, 2015, ANGPTL4 regulates the metastatic potential of oral squamous cell carcinoma, J. Oral Pathol. Med., 44, 126, 10.1111/jop.12212 · DOI
  124. Yi, 2013, Clinical significance of angiopoietin-like protein 4 expression in tissue and serum of esophageal squamous cell carcinoma patients, Med. Oncol., 30, 680, 10.1007/s12032-013-0680-y · DOI
  125. Shen, 2017, Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin, Cancer Lett., 386, 110, 10.1016/j.canlet.2016.11.012 · DOI
  126. Zhang, 2013, Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC, Exp. Ther. Med., 5, 119, 10.3892/etm.2012.750 · DOI
  127. Li, 2011, Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular carcinoma, Hepatology, 54, 910, 10.1002/hep.24479 · DOI
  128. Zidan, 2017, Angiopoietin-like protein 3 and 4 expression 4 and their serum levels in hepatocellular carcinoma, Cytokine, 96, 75, 10.1016/j.cyto.2017.03.006 · DOI
  129. Evans, 2014, Classifying patients for breast cancer by detection of autoantibodies against a panel of conformation-carrying antigens, Cancer Prev. Res., 7, 545, 10.1158/1940-6207.CAPR-13-0416 · DOI
  130. Johnson, 2015, Gene expression in “young adult type” breast cancer: A retrospective analysis, Oncotarget, 6, 13688, 10.18632/oncotarget.4051 · DOI
  131. Kanwar, 2015, Identification of genomic signatures in circulating tumor cells from breast cancer, Int. J. Cancer, 137, 332, 10.1002/ijc.29399 · DOI
  132. Yotsumoto, 2013, Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer, Mol. Cancer Res. MCR, 11, 506, 10.1158/1541-7786.MCR-12-0428 · DOI
  133. Adhikary, 2013, Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion, Oncogene, 32, 5241, 10.1038/onc.2012.549 · DOI
  134. Verine, J., Lehmann-Che, J., Soliman, H., Feugeas, J.P., Vidal, J.S., Mongiat-Artus, P., Belhadj, S., Philippe, J., Lesage, M., and Wittmer, E. (2010). Determination of Angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma. PLoS ONE, 5. · DOI
  135. Dong, 2017, Serum level of angptl4 as a potential biomarker in renal cell carcinoma, Urol. Oncol., 35, 279, 10.1016/j.urolonc.2016.12.017 · DOI
  136. Hsieh, H.Y., Jou, Y.C., Tung, C.L., Tsai, Y.S., Wang, Y.H., Chi, C.L., Lin, R.I., Hung, S.K., Chuang, Y.M., and Wu, S.F. (2017). Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment. Oncogene. · DOI
  137. Wang, 2015, Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer, Mol. Med. Rep., 11, 2789, 10.3892/mmr.2014.3029 · DOI
  138. Cui, 2010, Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation, J. Neuro-Oncol., 98, 297, 10.1007/s11060-009-0077-0 · DOI
  139. Marchio, 2012, A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6, EMBO Mol. Med., 4, 1156, 10.1002/emmm.201101164 · DOI

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Metadata

Authors
Carbone, C., Piro, G., Merz, V., Simionato, F., Santoro, R., Zecchetto, C., Tortora, G., & Melisi, D.
Affiliations
  • Digestive Molecular Clinical Oncology Research Unit, Department of Medicine, University of Verona, 37134 Verona, Italy
  • Medical Oncology Unit, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy
  • Laboratory of Oncology and Molecular Therapy, Department of Medicine, University of Verona, 37134 Verona, Italy
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-02-01
Volume
19
Issue
2
Pages
431
ISSN
1422-0067
DOI
10.3390/ijms19020431
PMC
PMC5855653
Cited by
200
References
7
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • AIRC IG (19111, 18599)
  • Basic Research Project 2015
  • Celgene Research Award 2017

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