Cited by 275Muscle Physiology and DisordersMetabolism, Diabetes, and CancerMuscle metabolism and nutrition

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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration

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Thomson, David M.·2018·International Journal of Molecular Sciences

DOI 10.3390/ijms19103125PMC PMC6212977

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Abstract

AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed. Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy.

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Additional file 10 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 9 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 5 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 7 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 11 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 13 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 1 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 2 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Additional file 2 of Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db/db mice
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Additional file 1 of Stevia (Stevia rebaudiana) extract ameliorates insulin resistance by regulating mitochondrial function and oxidative stress in the skeletal muscle of db/db mice
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Additional file 3 of Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
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Authors: Thomson, D. M.
Affiliations: Brigham Young University (US)
Corresponding author: Thomson, David M.
ORCID: Thomson, David M.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2018-10-11
Volume: 19
Issue: 10
Pages: 3125
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms19103125
PMC: PMC6212977
OpenAlex: W2896374260
Cited by: 267
References: 142
Citations by year: 2026: 29 · 2025: 36 · 2024: 41 · 2023: 52 · 2022: 40 · 2021: 31 · 2020: 24 · 2019: 13 · 2018: 1
FWCI: 1.68
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: AMPK, skeletal muscle growth, muscle hypertrophy, muscle atrophy, muscle regeneration, satellite cells, LKB1, AMPKα1, AMPKα2, muscle metabolism, myogenesis
MeSH terms: Animals, Energy Metabolism, Enzyme Activation, Humans, Hypertrophy, Organ Size, Regeneration, Wound Healing, Signal Transduction, Biomarkers, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, AMP-Activated Protein Kinases

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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration

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