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Cited by 90Birth, Development, and HealthDiet, Metabolism, and DiseaseGestational Diabetes Research and Management

Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring

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Kereliuk, Stephanie, Brawerman, Gabriel, Dolinsky, Vernon·2017·International Journal of Molecular Sciences
DOI 10.3390/ijms18071451PMC PMC5535942
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Abstract

Recent research aimed at understanding the rise in obesity and cardiometabolic disease in children suggests that suboptimal maternal nutrition conditions organ systems and physiological responses in the offspring contributing to disease development. Understanding the mechanisms by which the macronutrient composition of the maternal diet during pregnancy or lactation affects health outcomes in the offspring may lead to new maternal nutrition recommendations, disease prevention strategies and therapies that reduce the increasing incidence of cardiometabolic disease in children. Recent mechanistic animal model research has identified how excess fats and sugars in the maternal diet alter offspring glucose tolerance, insulin signaling and metabolism. Maternal nutrition appears to influence epigenetic alterations in the offspring and the programming of gene expression in key metabolic pathways. This review is focused on experimental studies in animal models that have investigated mechanisms of how maternal consumption of macronutrients affects cardiometabolic disease development in the offspring. Future research using “-omic” technologies is essential to elucidate the mechanisms of how altered maternal macronutrient consumption influences the development of disease in the offspring.

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Authors
Kereliuk, S., Brawerman, G., & Dolinsky, V.
Affiliations
Children's Hospital Research Institute of Manitoba (CA)
Corresponding author
Dolinsky, Vernon
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-07-06
Volume
18
Issue
7
Pages
1451
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms18071451
PMC
PMC5535942
OpenAlex
W2732676223
Cited by
90
References
114
Citations by year
2026: 4 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 23 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 3 · 2016: 1
FWCI
1.79
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Research Manitoba
  • Manitoba Medical Service Foundation
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
maternal nutrition, developmental origins of health and disease, cardiometabolic disease, childhood obesity, maternal diet during pregnancy, maternal diet during lactation, glucose tolerance, insulin signaling, epigenetic programming, metabolic programming, dietary fat, dietary sugar, animal models
MeSH terms
Animals, Dietary Carbohydrates, Dietary Fats, Female, Humans, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Nutritional Physiological Phenomena

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