The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
A Dual Role of Heme Oxygenase-1 in Cancer Cells
Open accessAbstract
Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.
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Cites
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Cited by
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Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
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Metadata
- Authors
- Chiang, S.-K., Chen, S.-E., & Chang, L.-C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-12-21
- Volume
- 20
- Issue
- 1
- Pages
- 39
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2905675459
- Cited by
- 465
- References
- 109
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- gold
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