Plasma Homocysteine and Risk of Mild Cognitive Impairment
Open accessAbstract
Background and Objective: There are conflicting data relating homocysteine levels to the risk of Alzheimer’s disease (AD). We sought to explore whether fasting plasma homocysteine is associated with the risk of mild cognitive impairment (MCI), an intermediate stage to dementia. Methods: Fasting levels of plasma homocysteine were obtained from 678 elderly subjects chosen at random from a cohort of Medicare recipients. There were longitudinal data in 516 subjects without MCI or dementia at baseline who were followed for 2,705 person-years. The relation of plasma homocysteine with prevalent and incident all-cause MCI, amnestic MCI and non-amnestic MCI was assessed using logistic and Cox proportional hazards regression analyses. Results: There were 162 cases of prevalent MCI and 132 cases of incident MCI in 5.2 years of follow-up. There was no association between plasma homocysteine and prevalence of MCI or amnestic or non-amnestic MCI in the cross-sectional analyses. There was no association between higher homocysteine levels and a lower risk of all-cause MCI. Consistent with the cross-sectional analyses, there was no specific association with the amnestic or non-amnestic subtype of MCI in crude or adjusted models. Conclusion: Plasma homocysteine levels measured at baseline were not related to MCI or its subtypes in an elderly multiethnic cohort.
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Of the 19 selected cohort studies linking Hcy to cognitive outcomes, 5 were not able to detect a significant association.
“and 5 were not able to detect a significant association [203,209,210,229,230].”
From Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis (2014) · cites this paper as [229]
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- Authors
- Reitz, C., Tang, M.-X., Miller, J., Green, R., & Luchsinger, J. A.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of California, Davis (US)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2008-12-16
- Volume
- 27
- Issue
- 1
- Pages
- 11-17
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC2698462
- OpenAlex
- W2069164663
- Cited by
- 38
- References
- 53
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 5 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG15294, P30AG015294, P01AG007232, AG 07702, AG 07232)
- National Center for Research Resources (RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- plasma homocysteine, mild cognitive impairment, Alzheimer's disease, amnestic mild cognitive impairment, non-amnestic mild cognitive impairment, dementia risk, older adults, hyperhomocysteinemia, biomarkers
- MeSH terms
- Aged, Amnesia, Apolipoproteins E, Cognition Disorders, Cross-Sectional Studies, Female, Genotype, Homocysteine, Humans, Longitudinal Studies, Male, Risk, Cohort Studies, Age of Onset
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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