The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials
Open accessPublished version of a preprint
Abstract
A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of anti-inflammatory mediators, cell membrane fluidity, intracellular signaling, and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represents a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.
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“Avallone and colleagues [90] stated that the protective effects exerted by n-3 LCPUFAs are likely to be modulated by patient-related factors, some of which may have a significant genetic component and may, therefore, be unmodifiable, and furthermore, may be unpredictable via routine clinical and biochemical evaluation.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [90]
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“The authors highlighted that inconsistent results are not unusual in clinical research between observational and randomized studies, particularly when investigating treatments with dietary supplements or integrators.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [90]
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“Therefore, Avallone and colleagues [90] concluded n-3 LCPUFA supplementation may indeed be a valuable and biologically plausible tool in the management of neurodegenerative diseases.”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [90]
In the citing paper
“A recent systematic review on the effects of n-3 LCPUFA supplementation on cognitive function in patients with PD or AD also reported an inconsistency between the evidence from prospective observational studies and randomized trials, and the authors suggested some potential reasons for the inconsistency [90].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [90]
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Citations
Cites
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Metadata
- Authors
- Avallone, R., Vitale, G., & Bertolotti, M.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Avallone, Rossella
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-08-30
- Volume
- 20
- Issue
- 17
- Pages
- 4256
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6747747
- OpenAlex
- W2963446643
- Cited by
- 218
- References
- 83
- Citations by year
- 2026: 14 · 2025: 43 · 2024: 35 · 2023: 29 · 2022: 37 · 2021: 31 · 2020: 28 · 2019: 1
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondazione Cassa di Risparmio di Modena (2018.0334)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- omega-3 fatty acids, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, dietary supplementation, polyunsaturated fatty acids, anti-inflammatory mediators, cell membrane fluidity, intracellular signaling, gene expression, disease prevention
- MeSH terms
- Clinical Trials as Topic, Humans, Fatty Acids, Omega-3, Neurodegenerative Diseases, Observational Studies as Topic
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