Cited by 424Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisContact Dermatitis and Allergies

The DOI matches its Crossref record; 226 of the 231 references it cites were found in a registry or an index.

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Open access

Furue, Masutaka·2020·International Journal of Molecular Sciences

Open this paper in CoChat — free account Open PDF

Abstract

Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction correlates with the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL). IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of transcription (STAT)6 and STAT3. In addition to IL-4 and IL-13, IL-22 and IL-17A are probably involved in the barrier dysfunction by inhibiting the expression of these barrier-related molecules. In contrast, natural or medicinal ligands for aryl hydrocarbon receptor (AHR) are potent upregulators of FLG, LOR, and IVL expression. As IL-4, IL-13, IL-22, and IL-17A are all capable of inducing oxidative stress, antioxidative AHR agonists such as coal tar, glyteer, and tapinarof exert particular therapeutic efficacy for AD. These antioxidative AHR ligands are known to activate an antioxidative transcription factor, nuclear factor E2-related factor 2 (NRF2). This article focuses on the mechanisms by which FLG, LOR, and IVL expression is regulated by IL-4, IL-13, IL-22, and IL-17A. The author also summarizes how AHR and NRF2 dual activators exert their beneficial effects in the treatment of AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms21155382

Cites

226 of 226 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy
Zhang, J., Sun, L., Li, W., Wang, Y., Li, X., & Liu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108844 · Cited by 15
Retracted
Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054
Secukinumab in plaque psoriasis—results of two phase 3 trials
Langley, R. G., Elewski, B. E., Lebwohl, M., Reich, K., Griffiths, C. E. M., Papp, K., Puig, L., Nakagawa, H., Spelman, L., Sigurgeirsson, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314258 · Cited by 1,997
The IL-17 Family of Cytokines in Health and Disease
McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.021 · Cited by 1,443
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,406
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026

Flagged first, then by citations

Show all 231 references

5 of the 231 references couldn’t be matched to a known paper.

Sorted by citations

Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis
Fang, Z., Pan, T., Li, L., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044723 · Cited by 273
Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review
Fang, Z., Li, L., Zhang, H., Zhao, J., Lu, W., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720393 · Cited by 200
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173
“barrier proteins such as FLG and LOR (42, 56).”
BackgroundInfluential
Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis
Furue, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113741 · Cited by 161
Self-citation
miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation
Jiao, P., Wang, X.-P., Luoreng, Z.-M., Yang, J., Jia, L., Ma, Y., & Wei, D.-W. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59876 · Cited by 151
Basics and recent advances in the pathophysiology of atopic dermatitis
Nakahara, T., Kido‐Nakahara, M., Tsuji, G., & Furue, M. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15664 · Cited by 142
Self-citation
Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
Fernández‐Gallego, N., Sánchez‐Madrid, F., & Cibrián, D. (2021) · Cells · doi:10.3390/cells10113176 · Cited by 138
Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Fania, L., Moretta, G., Antonelli, F., Scala, E., Abeni, D., Albanesi, C., & Madonna, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052684 · Cited by 128
Basic mechanisms of itch
Misery, L., Pierre, O., Gall‐Ianotto, C. L., Lebonvallet, N., Chernyshov, P. V., Garrec, R. L., & Talagas, M. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.05.004 · Cited by 121
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Phelps, C. M., Willis, N. B., Duan, T., Lee, A. H., Zhang, Y., Rodriguez J, D. M., Pandey, S. P., Laughlin, C. R., Rosen, A. B. I., McPherson, A. C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.018 · Cited by 91
Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis
Haddad, E., Cyr, S. L., Arima, K., McDonald, R. A., Levit, N. A., & Nestle, F. O. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00737-7 · Cited by 94
An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip
Kim, K., Kim, H., & Sung, G. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042116 · Cited by 77
Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
Humeau, M., Boniface, K., & Bodet, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.801579 · Cited by 75
Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human
Yamamura, Y., Nakashima, C., & Otsuka, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1342176 · Cited by 74
What’s New in Topicals for Atopic Dermatitis?
Kleinman, E. P., Laborada, J., Metterle, L., & Eichenfield, L. F. (2022) · American Journal of Clinical Dermatology · doi:10.1007/s40257-022-00712-0 · Cited by 73
Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review
Shetty, K., & Sherje, A. P. (2021) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-021-06558-y · Cited by 65
Role of Basophils in a Broad Spectrum of Disorders
Miyake, K., Ito, J., & Karasuyama, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.902494 · Cited by 65
Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism
Fang, Z., Pan, T., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147735 · Cited by 65
Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
Borgia, F., Pomi, F. L., Vaccaro, M., Alessandrello, C., Papa, V., & Gangemi, S. (2022) · Biomolecules · doi:10.3390/biom12121904 · Cited by 63
Immunopathogenesis of Atopic Dermatitis: Focus on Interleukins as Disease Drivers and Therapeutic Targets for Novel Treatments
Makowska, K., Nowaczyk, J., Blicharz, L., Waśkiel-Burnat, A., Czuwara, J., Olszewska, M., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010781 · Cited by 63
Oxidative stress affects the beginning of the growth of cancer cells through a variety of routes
Saleh, E. A. M., Al-dolaimy, F., Almajidi, Y. Q., Baymakov, S. R., Mohammed Abdul Kader, M., Ullah, M. I., Abbas, A., Khlewee, I. H., Bisht, Y. S., & Alsaalamy, A. H. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154664 · Cited by 62
Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
Napolitano, M., Fabbrocini, G., Martora, F., Picone, V., Morelli, P., & Patruno, C. (2021) · Cells · doi:10.3390/cells10123559 · Cited by 59
Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review
Upadhyay, P. R., Seminario‐Vidal, L., Abe, B. T., Ghobadi, C., & Sims, J. T. (2023) · Cells · doi:10.3390/cells12242793 · Cited by 60
TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes
Dai, X., Muto, J., Shiraishi, K., Utsunomiya, R., Mori, H., Murakami, M., & Sayama, K. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.01.005 · Cited by 57
Keratinocytes: new perspectives in inflammatory skin diseases
Ye, J., & Lai, Y. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.03.012 · Cited by 54
Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans
Nakajima, S., Tie, D., Nomura, T., & Kabashima, K. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155664 · Cited by 54
New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression
Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52
Age of onset defines two distinct profiles of atopic dermatitis in adults
Facheris, P., da Rosa, J. C., Pagan, A. D., Angelov, M., DUCA, E. D., Rabinowitz, G., Gómez‐Arias, P. J., Rothenberg‐Lausell, C., Estrada, Y. D., Bose, S. N., et al. (2023) · Allergy · doi:10.1111/all.15741 · Cited by 53
Immunological Aspects of Skin Aging in Atopic Dermatitis
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 53
“Outside-to-inside,” “inside-to-outside,” and “intrinsic” endogenous pathogenic mechanisms in atopic dermatitis: keratinocytes as the key functional cells involved in both permeability barrier dysfunction and immunological alterations
Hatano, Y., & Elias, P. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1239251 · Cited by 50
Skin as the target for allergy prevention and treatment
Marques‐Mejias, A., Bartha, I., Ciaccio, C. E., Chinthrajah, R. S., Chan, S., Hershey, G. K. K., Hui-Beckman, J. W., Kost, L. E., Lack, G., Layhadi, J. A., et al. (2024) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.12.030 · Cited by 52
Recent advances on application of polysaccharides in cosmetics
Wu, Q., Cheng, N., Fang, D., Wang, H., Rahman, F., Hao, H., & Zhang, Y. (2024) · Journal of Dermatologic Science and Cosmetic Technology · doi:10.1016/j.jdsct.2024.100004 · Cited by 51
Skin barrier-inflammatory pathway is a driver of the psoriasis-atopic dermatitis transition
Dong, S., Li, D., & Shi, D. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1335551 · Cited by 54
The evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective
David, E., Ungar, B., Renert‐Yuval, Y., Facheris, P., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14263 · Cited by 49
Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation
Landemaine, L., Costa, G. D., Fissier, E., Francis, C., Morand, S. C., Verbeke, J., Michel, M., Briandet, R., Sokol, H., Guéniche, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098160 · Cited by 50
Gut microbiota and skin pathologies: Mechanism of the gut-skin axis in atopic dermatitis and psoriasis
Chen, M., Wang, R., & Wang, T. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112658 · Cited by 49
Aryl hydrocarbon receptor/nuclear factor E2‐related factor 2 (AHR/NRF2) signalling: A novel therapeutic target for atopic dermatitis
Hwang, J., Newton, E. M., Hsiao, J. L., & Shi, V. Y. (2022) · Experimental Dermatology · doi:10.1111/exd.14541 · Cited by 47
Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients
Zhang, Y., Heinemann, N., Rademacher, F., Darvin, M. E., Raab, C., Keck, C. M., Vollert, H., Fluhr, J. W., Gläser, R., Harder, J., et al. (2022) · Antioxidants · doi:10.3390/antiox11061071 · Cited by 46
Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis
Koch, M., Kockmann, T., Rodríguez, E., Wehkamp, U., Hiebert, P., Greenwald, M. B., Stölzl, D., Beer, H., Tschachler, E., Weidinger, S., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.048 · Cited by 45
Tapinarof for psoriasis and atopic dermatitis: 15 years of clinical research
Bissonnette, R., Proulx, É. S., Jack, C. S., & Maari, C. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18925 · Cited by 41
The role of NRF2 transcription factor in inflammatory skin diseases
Salman, S., Paulet, V., Hardonnière, K., & Kerdine‐Römer, S. (2025) · BioFactors · doi:10.1002/biof.70013 · Cited by 43
Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin
Konger, R. L., Derr-Yellin, E. C., Zimmers, T. A., Katona, T. M., Xuei, X., Liu, Y., Zhou, H., Simpson, E. R., & Turner, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168634 · Cited by 37
Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications
Papa, V., Pomi, F. L., Borgia, F., Vaccaro, M., Pioggia, G., & Gangemi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097956 · Cited by 38
Exploring the potential of Halomonas levan and its derivatives as active ingredients in cosmeceutical and skin regenerating formulations
Erginer, M., Gökalsın, B., Tornacı, S., Sesal, C., & Öner, E. T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124418 · Cited by 36
Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients
Lang, C. C. V., Renert‐Yuval, Y., DUCA, E. D., Pavel, A. B., Wu, J., Zhang, N., Dubin, C., Obi, A., Chowdhoury, M., Kim, M., et al. (2021) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2021.04.023 · Cited by 35
Mesenchymal Stem Cells and Extracellular Vesicles Derived from Canine Adipose Tissue Ameliorates Inflammation, Skin Barrier Function and Pruritus by Reducing JAK/STAT Signaling in Atopic Dermatitis
Kim, S. Y., Yoon, T. H., Na, J., Yi, S. J., Jin, Y., Kim, M., Oh, T., & Chung, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094868 · Cited by 35
Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis
Tanei, R., & Hasegawa, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126682 · Cited by 33
Benvitimod Inhibits IL-4– and IL-13–Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes
Wang, X., Mao, D., Jia, J., & Zhang, J. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.027 · Cited by 33
Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway
Wang, P., Hu, G., Zhao, W., Du, J., You, M., Xv, M., Yang, H. Y., Zhang, M., Yan, F., Huang, M., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01308-w · Cited by 33
Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
Focken, J., Scheurer, J., Jäger, A., Schürch, C. M., Kämereit, S., Riel, S., Schaller, M., Weigelin, B., & Schittek, B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113148 · Cited by 32
Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review
Ständer, S., Luger, T. A., Kim, B., Lerner, E. A., Metz, M., Adiri, R., Canosa, J. M., Cha, A., & Yosipovitch, G. (2024) · Dermatology and Therapy · doi:10.1007/s13555-023-01081-0 · Cited by 31
Fermented blueberry and black rice containing Lactobacillus plantarum MG4221: a novel functional food for particulate matter (PM 2.5 )/dinitrochlorobenzene (DNCB)-induced atopic dermatitis
Hong, S. M., Kang, M. C., Jin, M., Lee, T. H., Lim, B. O., & Kim, S. Y. (2021) · Food & Function · doi:10.1039/d0fo02966a · Cited by 31
Managing Atopic Dermatitis with Lebrikizumab – The Evidence to Date
Labib, A., Ju, T., & Yosipovitch, G. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s295672 · Cited by 31
Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges
Dębińska, A., & Sozańska, B. (2023) · Nutrients · doi:10.3390/nu15051070 · Cited by 31
Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis
Xiao, S., Lu, Z., Steinhoff, M. S., Li, Y., Buhl, T., Fischer, M. J. M., Chen, W., Cheng, W., Zhu, R., Yan, X., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.211 · Cited by 30
Crosstalk between keratinocytes and immune cells in inflammatory skin diseases
Ni, X., & Lai, Y. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00028 · Cited by 30
Novel Therapeutic Targets for the Treatment of Atopic Dermatitis
Tsuji, G., Yamamura, K., Kawamura, K., Kido‐Nakahara, M., Ito, T., & Nakahara, T. (2023) · Biomedicines · doi:10.3390/biomedicines11051303 · Cited by 30
New Perspectives in the Management of Chronic Hand Eczema: Lessons from Pathogenesis
Tancredi, V., Buononato, D., Caccavale, S., Brizzi, E. V. D., Caprio, R. D., Argenziano, G., & Balato, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010362 · Cited by 29
Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.
Kim, E., Hong, S., Kim, J., Kim, M. S., Lee, Y., Sohn, Y., & Jung, H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114453 · Cited by 29
Bifidobacterium infantis strain YLGB ‐1496 possesses excellent antioxidant and skin barrier‐enhancing efficacy in vitro
Ma, X., Pan, Y., Zhao, W. H., Sun, P., Zhao, J., Yan, S., Wang, R., Han, Y., Liu, W., Tan, S., et al. (2022) · Experimental Dermatology · doi:10.1111/exd.14583 · Cited by 29
Wound healing activity of aqueous dispersion of fullerene C60 produced by “green technology”
Shershakova, N. N., Михайлович, А. С., Tomchuk, A. A., Makarova, E., Nikonova, A. A., Turetskiy, E. A., Андреевна, П. О., Kamyshnikov, O., Ivankov, O. I., Kyzyma, O. A., et al. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102619 · Cited by 29
Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling
Brusilovsky, M., Rochman, M., Shoda, T., Kotliar, M., Caldwell, J. M., Mack, L. E., Besse, J. A., Chen, X., Weirauch, M. T., Barski, A., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327276 · Cited by 28
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Chen, Y., Peng, C., Zhu, L., Wang, J., Cao, Q., Chen, X., & Li, J. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08995-3 · Cited by 27
Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice
Oh, J.-S., Lee, S.-J., & Choung, S. (2021) · Nutrients · doi:10.3390/nu13093209 · Cited by 27
A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
Radi, G., Campanati, A., Diotallevi, F., Martina, E., Marani, A., & Offidani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112700 · Cited by 27
Polycyclic aromatic hydrocarbons in bone homeostasis
Ye, Q., Xi, X., Fan, D., Cao, X., Wang, Q., Wang, X., Zhang, M., Wang, B., Tao, Q., & Xiao, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112547 · Cited by 26
Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions
Gu, Q., Lin, J., Lü, X., Chen, T., Yunyang, W., & Yang, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115428 · Cited by 26
NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products
Frantz, M., Rozot, R., & Marrot, L. (2022) · BioFactors · doi:10.1002/biof.1907 · Cited by 29
Interactions between Malassezia and New Therapeutic Agents in Atopic Dermatitis Affecting Skin Barrier and Inflammation in Recombinant Human Epidermis Model
Lee, Y. J., Yassa, C., Park, S.-H., Song, S. W., Jung, W. H., Lee, Y. W., Kang, H., & Kim, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076171 · Cited by 26
MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-κB pathway
Yan, C., Ying, J., Wang, L., Changzhi, Y., Qian, Q., Jingzhu, M., Dongjie, S., & Tingting, Z. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104452 · Cited by 26
Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus
Wang, Y., Lu, H., Cheng, L., Guo, W., Hu, Y., Du, X., Liu, X., Xu, M., Liu, Y., Zhang, Y., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155856 · Cited by 25
3-Bromo-4,5-dihydroxybenzaldehyde Isolated from Polysiphonia morrowii Suppresses TNF-α/IFN-γ-Stimulated Inflammation and Deterioration of Skin Barrier in HaCaT Keratinocytes
Jayasinghe, A. M. K., Han, E. J., Kirindage, K. G. I. S., Fernando, I. P. S., Kim, E.-A. L., Kim, J., Jung, K., Kim, K., Heo, S., & Ahn, G. (2022) · Marine Drugs · doi:10.3390/md20090563 · Cited by 26
Dupilumab Alters Both the Bacterial and Fungal Skin Microbiomes of Patients with Atopic Dermatitis
Umemoto, N., Kakurai, M., Matsumoto, T., Mizuno, K., Cho, O., Sugita, T., & Demitsu, T. (2024) · Microorganisms · doi:10.3390/microorganisms12010224 · Cited by 24
Deacetylasperulosidic Acid Ameliorates Pruritus, Immune Imbalance, and Skin Barrier Dysfunction in 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis NC/Nga Mice
Oh, J.-S., Seong, G.-S., Kim, Y. D., & Choung, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010226 · Cited by 24
Biologic and small-molecule therapy for treating moderate to severe atopic dermatitis: Mechanistic considerations
Rothenberg‐Lausell, C., Bar, J., Dahabreh, D., Renert‐Yuval, Y., DUCA, E. D., & Guttman‐Yassky, E. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.04.009 · Cited by 27
The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted Therapies
Pala, V., Rosset, F., Mastorino, L., Sciamarrelli, N., Boskovic, S., Borriello, S., Bongiovanni, E., Crespi, O., Ribero, S., & Quaglino, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110720 · Cited by 24
Expression of barrier proteins in the skin lesions and inflammatory cytokines in peripheral blood mononuclear cells of atopic dogs
Kanwal, S., Singh, S. K., Soman, S. P., Choudhury, S., Kumari, P., Ram, P. K., & Garg, S. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-90992-z · Cited by 23
Huanglian ointment alleviates eczema by maintaining the balance of c-Jun and JunB and inhibiting AGE-RAGE-mediated pro-inflammation signaling pathway
Wang, S., Wang, Y., Han, B., Chen, Y., Bai, X., Yu, S., & Liu, M. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154372 · Cited by 23
Potential Therapeutic Skin Microbiomes Suppressing Staphylococcus aureus-Derived Immune Responses and Upregulating Skin Barrier Function-Related Genes via the AhR Signaling Pathway
Lee, E., Min, K., Ahn, H., Jeon, B., Park, S., Yun, C., Jeon, H., Yeon, J.-S., Kim, H., & Park, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179551 · Cited by 23
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Lie, E., Choi, M., Wang, S., & Eichenfield, L. F. (2023) · Pediatric Drugs · doi:10.1007/s40272-023-00592-9 · Cited by 23
Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models
van den Brink, N. J. M., Pardow, F., Meesters, L. D., van Vlijmen‐Willems, I. M. J. J., Rodijk‐Olthuis, D., Niehues, H., Jansen, P. A. M., Roelofs, S. H., Brewer, M. G., van den Bogaard, E. H. J., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.038 · Cited by 22
Staphylococcus Infection: Relapsing Atopic Dermatitis and Microbial Restoration
Hulme, J. (2023) · Antibiotics · doi:10.3390/antibiotics12020222 · Cited by 22
The impact of dupilumab on skin barrier function: A systematic review
Montero‐Vílchez, T., la Torre, R. S.-D., Sánchez‐Díaz, M., Ureña‐Paniego, C., Molina‐Leyva, A., & Arias‐Santiago, S. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19081 · Cited by 22
Regulatory mechanism of the IL-33-IL-37 axis via aryl hydrocarbon receptor in atopic dermatitis and psoriasis
Tsuji, G., Yamamura, K., Kawamura, K., Kido-Nakahara, M., Ito, T., & Nakahara, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914633 · Cited by 21
Gamma‐delta ( γδ ) T cell‐derived cytokines ( IL ‐4, IL ‐17, IFN ‐γ and IL ‐10) and their possible implications for atopic dermatitis development
Fagundes, B. O., de Sousa, T. R., & Victor, J. R. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16364 · Cited by 21
Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function
Wang, X., Wang, Q., Yin, P., Chen, L., Zhao, X., Wen, D., & Tan, Y. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03697-8 · Cited by 21
Cell-Based Model Systems for Validation of Various Efficacy-Based Claims for Cosmetic Ingredients
Singh, P., Bhat, S. S., Singh, N. K., Venkanna, B. U., Rafiq, M., & Rao, R. P. (2022) · Cosmetics · doi:10.3390/cosmetics9050107 · Cited by 21
Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice
Kishi, R., Toyama, S., Tominaga, M., Kamata, Y., Komiya, E., Kaneko, T., Suga, Y., & Takamori, K. (2023) · Cells · doi:10.3390/cells12020239 · Cited by 21
Exosomes derived from human dermal fibroblasts ( HDFn‐Ex ) alleviate DNCB ‐induced atopic dermatitis (AD) via PPARα
Jang, Y. N., Lee, J. O., Lee, J. M., Park, A. Y., Kim, Y. J., Kim, S., Seok, J., Yoo, K. H., & Kim, B. J. (2023) · Experimental Dermatology · doi:10.1111/exd.14970 · Cited by 21
Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection
Janjetović, Z., & Slominski, A. T. (2024) · Cosmetics · doi:10.3390/cosmetics11020037 · Cited by 23
Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes
Yan, X., Tsuji, G., Hashimoto-Hachiya, A., & Furue, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216338 · Cited by 20
Self-citation
Mast cell–neuron axis as a core mechanism in chronic pruritus of atopic dermatitis: from mechanistic insights to therapeutic targets
Li, D., Han, Y., Zhou, J., Yang, H., Chen, J., Tey, H. L., & Tan, T. T. Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1645095 · Cited by 21
Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes
Dong, L., Kim, H. J., Cao, T. Q., Liu, Z., Lee, H., Ko, W., Kim, Y., Sohn, J. H., Kim, T. K., Yim, J. H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189674 · Cited by 20
Identification of Potential Key Biomarkers and Immune Infiltration in Oral Lichen Planus
Geng, L., Zhang, X., Tang, Y., & Gu, W. (2022) · Disease Markers · doi:10.1155/2022/7386895 · Cited by 20
The contribution of mouse models to understanding atopic dermatitis
Sanjel, B., & Shim, W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115177 · Cited by 20
Screening and Research on Skin Barrier Damage Protective Efficacy of Different Mannosylerythritol Lipids
Jing, C., Guo, J., Li, Z., Xu, X., Wang, J., Zhai, L., Liu, J., Sun, G. W., Wang, F., Xu, Y., et al. (2022) · Molecules · doi:10.3390/molecules27144648 · Cited by 20
Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis
Huang, Y., Chen, L., Liu, F., Xiong, X., Ouyang, Y., & Deng, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1300378 · Cited by 21
Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis
Chiocchetti, R., Silva, M. D., Aspidi, F., Cunha, R. Z., Gobbo, F., Tagliavia, C., Sarli, G., & Morini, M. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.915896 · Cited by 20
From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut–Skin Axis—Clinical Outcomes and Microbiome Implications
Micu, A. E., Popescu, I. A., Halip, I. A., Mocanu, M., Vâță, D., Hulubencu, A. L., Gheuca-Solovastru, D. F., & Solovăstru, L. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010365 · Cited by 19

Authors: Furue, M.
Affiliations: Kyushu University (JP)
Corresponding author: Furue, Masutaka
ORCID: Furue, Masutaka
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2020-07-29
Volume: 21
Issue: 15
Pages: 5382
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms21155382
PMC: PMC7432778
OpenAlex: W3046068546
Cited by: 419
References: 231
Citations by year: 2026: 83 · 2025: 82 · 2024: 81 · 2023: 74 · 2022: 64 · 2021: 32 · 2020: 2
FWCI: 7.19
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministry of Health, Labour and Welfare (H30-Shokuhin-Shitei-005)
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (C, FAG0K08692)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: atopic dermatitis, filaggrin, loricrin, involucrin, skin barrier dysfunction, IL-4, IL-13, IL-17A, IL-22, aryl hydrocarbon receptor, Nrf2, STAT6, STAT3, oxidative stress, coal tar, tapinarof, AhR agonists
MeSH terms: Filaggrin Proteins, Interleukin-22, Antioxidants, Coal Tar, Dermatitis, Atopic, Gene Expression Regulation, Humans, Interleukins, Membrane Proteins, S100 Proteins, Protein Precursors, Resorcinols, Skin, Stilbenes, Tars, Signal Transduction, Interleukin-4, Receptors, Aryl Hydrocarbon, Oxidative Stress, Interleukin-13, Interleukin-17, STAT3 Transcription Factor, STAT6 Transcription Factor, NF-E2-Related Factor 2, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks