Androgen action in the ovary
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Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell proliferation. It is likely only in mature antral follicles that androgens encourage apoptosis and consequent follicle atresia, and this may be an important mechanism to ensure mono-follicular ovulation in primates, including humans. Recent studies have provided new insight into the mechanism of androgen signaling in the ovary which involves both genomic and non-genomic effects that are complementary in effecting a cellular response. In polycystic ovary syndrome, a condition characterized by intra-ovarian androgen excess, aberrant development of both preantral and antral follicles is a salient feature. We present evidence that local action of androgens plays a part in such abnormalities. Finally, we review the role of androgens in follicle atresia and conclude that the effects are part of the normal physiology of follicle maturation.
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Aberrant development during the earliest stages of follicular growth likely contributes to the ovarian aspects of PCOS.
“Aberrant development during these earliest stages of follicular growth likely contributes to the ovarian aspects of PCOS [19].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [19]
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- Authors
- Franks, S., & Hardy, K.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Franks, Stephen
- ORCID
- Franks, Stephen
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-10
- Volume
- 9
- Pages
- 452-452
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6097027
- OpenAlex
- W2886792139
- Cited by
- 109
- References
- 78
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 18 · 2020: 9 · 2019: 6 · 2018: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- androgens, ovary, androgen signaling, folliculogenesis, granulosa cell proliferation, follicular atresia, apoptosis, polycystic ovary syndrome, estradiol secretion, follicle maturation
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