A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application

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C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency

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Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis

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Probing Protein Structural Changes in Alzheimer’s Disease via Quantitative Cross-linking Mass Spectrometry

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Accelerated Wound Border Closure Using a Microemulsion Containing Non-Inhibitory Recombinant α1-Antitrypsin

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The lipid ties of α1-antitrypsin: Structural and functional aspects

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Evaluation of the diagnostic performance of Alpha-1-Antitrypsin in early detection of hepatocellular carcinoma

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Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration

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Genetic and Serum Screening for Alpha-1-Antitrypsin Deficiency in Adult Patients with Cystic Fibrosis: A Single-Center Experience

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The knockout of cytoglobin 1 in zebrafish (Danio rerio) alters lipid metabolism, iron homeostasis and oxidative stress response

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Evaluation of Salivary Biomarkers and Spirometry for Diagnosing COPD in Non-Smokers and Smokers of Polish Origin

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A deep-learning framework reveals whole-body perturbations at cell level

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Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

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Plasma proteomic profiles reveal immune modulation by immunonutrition in GI cancer

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Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases

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Technoeconomic Analysis of Intensified PEGylated Biopharmaceutical Recombinant Protein Production: Alpha Antitrypsin as a Model Case

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Potential drug targets for Neuromyelitis optica spectrum disorders (NMOSD): A Mendelian randomization analysis

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Yoga Therapy Attenuates the Progression of Diabetes – Insights from Proteomics and Metabolomics Analysis

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Molecular characterization and functional analysis of AAT and SAA in Lateolabrax maculatus and Micropterus salmoides

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Serum Alpha-1-Antitrypsin and Folic Acid as Biomarkers for Glaucoma Risk

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Comparison of COVID-19 Outcomes With Alpha-1 Antitrypsin Deficiency Prevalence in Europe: A Cross-Sectional Study

Sezgin, Y., Becel, S., & Kaplan, A. K. (2023) · Cureus · doi:10.7759/cureus.34293 · Cited by 2 · see citing works

Long Non-Coding RNA Expression in Alpha-1 Antitrypsin Deficient Monocytes Pre- and Post-AAT Augmentation Therapy

Smith, S. G. J., & Greene, C. M. (2023) · Non-Coding RNA · doi:10.3390/ncrna9010006 · Cited by 2 · see citing works

Pi*S and Pi*Z Alleles of SERPINA1 Gene Are Associated With Specific Variants of a BRD4‐Independent Enhancer

Escuela-Escobar, A., Luis, E. H., Martín-González, E., Pérez, J. M. H., Carracedo, M. A. G., & Pérez, J. A. P. (2024) · Human Mutation · doi:10.1155/2024/6472805 · Cited by 1 · see citing works

Association of Escherichia coli pathotypes with fecal markers of enteropathy and nutritional status among underweight adults in Bangladesh

Sthity, R. A., Islam, M. Z., Sagar, M. E. K., Gazi, M. A., Ferdous, J., Kabir, M. M., Mahfuz, M., Ahmed, T., & Mostafa, I. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1553688 · Cited by 1 · see citing works

Characteristics of bronchiectasis in patients with different genotypes of severe α 1 -antitrypsin deficiency from the EARCO registry

Mirizzi, F. M., Aljama, C., Santus, P., Mantero, M., Omčikus, M., Torres‐Durán, M., Turner, A. M., Tanash, H. A., Rodríguez‐García, C., Jensen, J. S., et al. (2025) · ERJ Open Research · doi:10.1183/23120541.00491-2025 · Cited by 1 · see citing works

Alpha1-antitrypsin protects the intestine from ischemia-reperfusion injury in a rat intestinal clamping model

Dubois, A., Clarysse, M., Farré, R., Wylin, T., Heetfeld, V., Canovai, E., Vanuytsel, T., Hertogh, G. D., Pirenne, J., & Ceulemans, L. J. (2025) · Intestinal failure. · doi:10.1016/j.intf.2025.100314 · Cited by 1 · see citing works

Concentrated Polymer Brush-Modified Magnetic Particles for a Diagnostic Immunoassay

Huynh, G. T., Qiu, J. H., van den Bosch, E., Yamazaki, T., & Yoshikawa, C. (2025) · Langmuir · doi:10.1021/acs.langmuir.5c04175 · Cited by 1 · see citing works

Alpha-1 antitrypsin deficiency and cardiovascular disease: a review

David, S. V., Nordestgaard, B. G., & Dahl, M. (2026) · Respiratory Research · doi:10.1186/s12931-026-03517-5 · Cited by 1 · see citing works

Advances in Precision Editing Therapies for Alpha-1 Antitrypsin Deficiency

Gao, J., Sontheimer, E. J., Flotte, T. R., & Xue, W. (2026) · Human Gene Therapy · doi:10.1177/10430342261417356 · Cited by 1 · see citing works

Alpha-1 Antitrypsin Protects Against Cisplatin-Induced Acute Kidney Injury by Restoring Redox and Mitochondrial Homeostasis

Kim, M.-A., Oh, S., Han, J., Ahn, J., Oh, E., Jung, H., Choi, J., Cho, J., Park, S.-H., Kim, C., et al. (2026) · Biomolecules · doi:10.3390/biom16020222 · Cited by 1 · see citing works

ALPHA-1-ANTITRYPSIN – A BIOMARKER OF ANTIPROTEASE PROTECTION IN THE PREDICTION OF PREMATURE BIRTH IN COVID-19 AND HEALTHY PREGNANT WOMEN

Komarevtseva, I. O., Chernykh, Y. A., Cherednichenko, R. V., Zielonyi, I. I., Brezhnyeva, Y. V., Komarevtsev, V. N., & Shipilova, I. V. (2023) · World of Medicine and Biology · doi:10.26724/2079-8334-2023-4-86-86-91 · Cited by 1 · see citing works

Effects of Chymotrypsin Therapy on Alpha 1-Anti Trypsin and Glutathione Peroxidase in Facial Skin of Rabbits Injected by Hyaluronic Acid

Al-Najjar, A., & Al-Mashhadane, F. (2024) · Egyptian Journal of Veterinary Science · doi:10.21608/ejvs.2024.253010.1696 · Cited by 1 · see citing works

Oral Full Texts

(2023) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2023-48s107 · Cited by 1 · see citing works

Increased risk of nonmelanoma skin cancer in patients with alpha‐1 antitrypsin deficiency: A nationwide cohort study

Korsbæk, N. J., Landt, E., Marott, S. C. W., Nordestgaard, B. G., Vinding, G. R., Jemec, G. B. E., & Dahl, M. (2024) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20040 · Cited by 1 · see citing works

Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy

Suphapimol, V., Liu, Y., Prato, S., Karnowski, A., Hardy, C. L., Morelli, A. B., Jayasimhan, A., Deliyanti, D., & Wilkinson‐Berka, J. L. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00431-3 · Cited by 1 · see citing works

Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra

Tammen, H., Pich, A., Hess, R., Lechowicz, U., Janciauskiene, S. M., & Chorostowska‐Wynimko, J. (2025) · Methods · doi:10.1016/j.ymeth.2025.04.004 · Cited by 1 · see citing works

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

Richmond, A., Robertson, J. A., Smith, H. M., Hillary, R. F., Zelezniak, A., Vernardis, S. I., Chybowska, A. D., Grauslys, A., Mur, J., Campbell, A. I., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76474-8 · Cited by 1 · see citing works

Deep Learning and 3D Imaging Reveal Whole-Body Alterations in ObesityPreprint

Kaltenecker, D., Horvath, I., Al-Maskari, R., Kolabas, Z. I., Chen, Y., Hoeher, L., Todorov, M. I., Kapoor, S., Ali, M., Kofler, F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.18.608300 · Cited by 1 · see citing works

Serum Protein Electrophoresis Bands As Biomarkers for Drug-Sensitive Pulmonary Tuberculosis

Sinha, P., Ranjan, R. K., Shankar, M., Bharti, A., & Shekhar, R. (2023) · Cureus · doi:10.7759/cureus.44424

Accurate Identification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular Assay

Decurtis, E. K., Kuss-Duerkop, S. K., Machado, I. M. P., Stewart, Z. P., Jackson, M., Hasenohr, E., Crumby, J. L., Groshong, S. D., Coeshott, C. M., Harbeck, R. J., et al. (2024) · CHEST Pulmonary · doi:10.1016/j.chpulm.2024.100076

Proteomic profile in plasma as a biomarker of pregnancy in cows

Mojsym, W., Wawrzykowski, J., & Kankofer, M. (2024) · Reproduction in Domestic Animals · doi:10.1111/rda.14667

Identification of High-Risk Lower Extremity Wounds Using Point-of-Care Test for Bacterial Protease Activity; A Single-Centre, Single-Blinded, Prospective Study

Jonker, L., Todhunter, J., Mutch, R., Lowes, D., & Messenger, G. (2024) · The International Journal of Lower Extremity Wounds · doi:10.1177/15347346241284804

Assessment of the Potential Impact of Mycophenolate Mofetil on Lowering Renal Biomarkers in Patients with Class III Lupus Nephritis: A Pilot Study to Predict Renal Function Progress

Mohammed, N. H., Al‐Taie, A., & Al-Sultany, F. H. (2024) · Biomedical and Biotechnology Research Journal (BBRJ) · doi:10.4103/bbrj.bbrj_16_24

Oxidation-Dependent Effects of Alpha-1 Antitrypsin on Wound Healing and Inflammation: Implications for Tissue RepairPreprint

Farber, I., Sheffer, L., Anav, Y., Halpern, D., Pinto, N., Cohen, S., Darawsha, A., Ogen‐Shtern, N., El‐Saied, S., Lewis, E. C., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4975765/v1

Protein phosphatase 2A activators under investigation for smoking-related chronic obstructive pulmonary disease and related disorders

Antoniu, S. A., & Rascu, S. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2416982

Glycated ɑ1-Antitrypsin Involvement in Impaired Wound Healing: In- Vivo and In-Vitro ModelsPreprint

Farber, I., Naumchik, A., Istoyler, Y., Zaknoun, M., Anav, Y., Sheffer, L., Schuster, R., Halpern, D., Fridman, V., Cohen-Lahav, M., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4931520/v1

Analysis of key parameters of the hemostatic system in patients with osteoarthritis after COVID-19

Rachkovska, A., Krenytska, D., Karbovskyy, V. L., Tsyryuk, O., Penchuk, Y., Коt, L., Raksha, N., Falalyeyeva, T. M., Savchuk, О., & Остапченко, Л. І. (2025) · Minerva Biotechnology and Biomolecular Research · doi:10.23736/s2724-542x.25.03239-0

Galectin-8 binding to alpha-1 antitrypsin is a physiological mechanism in healthy individuals but exacerbates the symptoms of alpha-1 antitrypsin deficiency

Sayed, H., Mayo, K. H., Zhou, Y., Tai, G., & Su, J. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110577

Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients

Ali, R. A., Mohammedsaeed, W. M., Fakher, M., Noor, H. K., & Qurashi, Y. M. A. A. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-11699-4

Association of AAT/ SERPINA1 PI*Z Variant with Gestational Duration and Prevention of Premature Birth in Knockout Mice by AAT-SupplementationPreprint

Koivulehto, E., Pasanen, A., Haapalainen, A. M., Tiensuu, H., FinnGen, Rämet, M., & Hallman, M. (2025) · medRxiv · doi:10.1101/2025.11.21.25340724

Rapid design and production of Alpha-1 antitrypsin fusion proteins in a plant-based cell-free expression system

Karmaker, A., Alyami, F., Randolph, C. A., Ranade, S., Liu, Y., Thyagatur, A., Wong, J., Zaini, P. A., Williams, C., Dandekar, A. M., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.12.012

Human Alpha-1 Antitrypsin Suppresses Melanoma Growth by Promoting Tumor Differentiation and CD8+ T-Cell-Mediated Immunity

Yamauchi, T., Luo, Y., Menon, D. R., Couts, K. L., Khan, S., Goel, A., Dinarello, C. A., Zhai, Z., & Fujita, M. (2026) · Biomolecules · doi:10.3390/biom16010122

Alpha-1-antitrypsin (AAT) inhibits Mycobacterium intracellulare induction of monocyte colony stimulating factor: another host-defense function of AATPreprint

Bai, X., Narum, D. E., Eyre, C., Gao, J., & Chan, E. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.20.706890

Glycated and Non-Glycated Human Alpha-1 Antitrypsin in Hyperglycemic Wound Healing: In Vivo and In Vitro Models

Färber, Naumchik, A., Istoyler, Y., Zaknoun, M., Anav, Y., Sheffer, L., Schuster, R., Halpern, D., Fridman, V., Cohen-Lahav, M., et al. (2026) · Biology · doi:10.3390/biology15080606

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors

Lietz, S., & Barth, H. (2026) · Toxins · doi:10.3390/toxins18050208

Alpha-1 antitrypsin: therapeutic applications beyond serine protease inhibition

Toldo, M., Patel, T., Golino, M., Refrigeri, E., Kelly, J., Abbate, A., Mezzaroma, E., & Toldo, S. A. (2026) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2026.2681588

Alpha-1 antitrypsin deficiency associated with increased risk of venous thromboembolism: a nationwide cohort study in Denmark

David, S. V., Fromme, M., Remih, K., Nordestgaard, B. G., Strnad, P., & Dahl, M. (2026) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2026.106827

Human α1-Antitrypsin Inhibits Nociceptor Excitability and Relieves Inflammatory and Neuropathic Pain

Waters, A. L., Loya‐López, S., Rodríguez-Palma, E. J., Eans, S. O., Shinouchi, R., Stokes, J., McLaughlin, J. P., Song, S., & Khanna, R. (2026) · Biomolecules · doi:10.3390/biom16081074

Comparative Analysis of Progesterone Secretion and Plasma Proteome Across the Pregnant and Non-Pregnant Luteal Phase of the Koala (Phascolarctos cinereus)

Hartley, B. E., Johnston, S., Campbell, Y., Fanson, K. V., Nicolson, V., Neal, A., & Pini, T. (2026) · Proteomes · doi:10.3390/proteomes14030040

AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice

Koivulehto, E., Pasanen, A., Haapalainen, A. M., Tiensuu, H., Rämet, M., & Hallman, M. (2026) · Nature Communications · doi:10.1038/s41467-026-76643-9

CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation

Gao, H., Guo, Y., Wang, L., Shen, Y., & Liu, W. (2026) · PLoS ONE · doi:10.1371/journal.pone.0353352

Protein Fragments: From Biomarkers to Therapeutic Targets—A Focus on α1‐Antitrypsin‐Derived Peptides

Börner, F., Iwanicki, T., Held, J., Chorostowska‐Wynimko, J., Jezela‐Stanek, A., & Janciauskiene, S. M. (2026) · Mediators of Inflammation · doi:10.1155/mi/6516930

Causal roles of phenotypic age acceleration and metabolic health on dementia: a Mendelian randomisation and structure learning studyPreprint

Baousi, A., Dobinda, K., Zhu, J., Yu, X., Muir, K. R., Lophatananon, A., McMillan, B., Clarkson, P., Tang, E. Y. H., & Guo, H. (2026) · medRxiv · doi:10.64898/2026.09.01.26360731

Obstructive Sleep Apnea in Individuals with Alpha-1 Antitrypsin Deficiency: A Single Center Experience

Boppana, L. K. T., Cai, X., Schweitzer, M. D., & Yurcheshen, M. E. (2026) · Lung · doi:10.1007/s00408-026-00935-6

Purification and Trypsin-Inhibitory Kinetics of Human Serum Alpha-1 Antitrypsin

Fayadh, F. A., & Hussein, A. D. (2026) · BIO Web of Conferences · doi:10.1051/bioconf/202625604004

Perspectives on current practices and future research directions in alpha-1 antitrypsin deficiency

McElvaney, N. G., Chorostowska-Wynimko, J., Miravitlles, M., Turner, A. M., Clarenbach, C. F., Herth, F. J. F., Barrecheguren, M., Costa, F. D., Ficker, J. H., Mornex, J., et al. (2026) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666261494062

Immune-modulating effects of alpha-1 antitrypsin

Ehlers, M. R. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0161 · Cited by 118 · see citing works

The lipid ties of α1-antitrypsin: Structural and functional aspects

Segal, L., & Lewis, E. C. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104528 · Cited by 7 · see citing works

Alpha-1 Antitrypsin: A Potent Anti-Inflammatory and Potential Novel Therapeutic Agent

Bergin, D. A., Hurley, K., McElvaney, N. G., & Reeves, E. P. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0162-5 · Cited by 132 · see citing works

Novel Mechanisms Of Immune Modulation By Alpha-1-Antitrypsin

Rice, L. V., Dimeloe, S., Nyon, M. P., Haq, I., Irving, J. A., McDonnell, J. M., Gooptu, B., Kemper, C., & Hawrylowicz, C. M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.509

Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential

Mazzuca, C., Vitiello, L., Travaglini, S., Maurizi, F., Finamore, P., Santangelo, S., Rigon, A., Vadacca, M., Angeletti, S., & Scarlata, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1443297 · Cited by 31 · see citing works