Effects of bile acid modulation by dietary fat, cholecystectomy, and bile acid Sequestrant on energy, glucose, and lipid metabolism and gut microbiota in mice
Open accessAbstract
Bile acid metabolism, involved with the digestion and absorption of nutrients in the gut, is linked to the gut microbiota community, greatly impacting the host’s metabolism. We examined the hypothesis that the modulation of bile acid metabolism by dietary fat contents, gallbladder removal (GBX; cholecystectomy), and bile acid sequestrant (BAS; cholestyramine) treatment could alter energy, glucose, and lipid metabolism through the changes in the gut microbiota. Mice were randomly assigned to the following six groups: (1) Sham GBX surgery (Sham) + low fat/high carbohydrate diet (LFD), (2) Sham + high fat diet (HFD), (3) Sham + HFD + BAS, (4) GBX + LFD, (5) GBX + HFD, and (6) GBX + HFD + BAS. BAS groups received 2% cholestyramine. After an 8-week intervention, energy, glucose, and lipid metabolism, and the gut microbiota community were measured. HFD groups exhibited higher body weight gain than LFD, and GBX increased the weight gain comped to Sham groups regardless of BAS in HFD (p < 0.05). Homeostatic model assessment for insulin resistance (HOMA-IR) was higher in HFD than LFD, and GBX increased it regardless of BAS. Serum lipid profiles were worsened in GBX + HFD compared to Sham + LFD, whereas BAS alleviated them, except for serum HDL cholesterol. Hepatic tumor-necrosis-factor-α (TNF-α) mRNA expression and lipid peroxide contents increased with GBX and BAS treatment compared to Sham and no BAS treatment (p < 0.05). Hepatic mRNA expression of sterol regulatory element-binding transcription factor 1c (SREBP1c) and peroxisome proliferator-activated receptor gamma (PPAR-γ) exhibited the same trend as that of tumor necrosis factor-α (TNF-α). The α-diversity of gut bacteria decreased in GBX + HFD and increased in GBX + HFD + BAS. Akkermentia, Dehalobacterium, SMB53, and Megamonas were high in the Sham + LFD, and Veillonella and Streptococcus were rich in the Sham + HFD, while Oscillospira and Olsenella were high in Sham + HFD + BAS (p < 0.05). GBX + LFD increased Lactobacillus and Sutterella while GBX + HFD + BAS elevated Clostridium, Alistipes, Blautia, Eubacterium, and Coprobacillus (p < 0.05). In conclusion, the modulation of bile acid metabolism influences energy, glucose, and lipid metabolisms, and it might be linked to changes in the gut microbiota by bile acid metabolism modulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sutterella is intricately involved in bile acid metabolism, thereby regulating disorders of lipid metabolism.
“Sutterella, a Gram-negative bacterium, is intricately involved in bile acid metabolism, thereby regulating disorders of lipid metabolism (Park et al., 2022).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Park et al., 2022
The Results (§2.5, page unavailable) report increased Sutterella abundance in cholecystectomized mice fed a low-fat diet. The Discussion (§3, page unavailable) links bile-acid modulation, gut-microbiota changes, and lipid metabolism more broadly, but does not show that Sutterella itself metabolizes bile acids or regulates lipid-metabolism disorders. The passages also do not identify it as Gram-negative. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Role of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
Chiang, J. Y. L., & Ferrell, J. M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00223.2019 · Cited by 580 · see citing works
Bile acid nuclear receptor FXR and digestive system diseases
Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.004 · Cited by 477 · see citing works
The Role of the Gut Microbiota in Bile Acid Metabolism
Ramírez-Pérez, O., Cruz-Ramón, V., Chinchilla-López, P., & Méndez‐Sánchez, N. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.5672 · Cited by 393 · see citing works
Network analysis methods for studying microbial communities: A mini review
Matchado, M. S., Lauber, M., Reitmeier, S., Kacprowski, T., Baumbach, J., Haller, D., & List, M. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.05.001 · Cited by 349 · see citing works
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333 · see citing works
Wang, B., Kong, Q., Xiu, L., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2020) · Nutrients · doi:10.3390/nu12103197 · Cited by 327 · see citing works
Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice
Zheng, X., Huang, F., Zhao, A., Lei, S., Zhang, Y., Xie, G., Chen, T., Qu, C., Rajani, C., Dong, B., et al. (2017) · BMC Biology · doi:10.1186/s12915-017-0462-7 · Cited by 323 · see citing works
Peinnequin, A., Mouret, C., Birot, O., Alonso, A., Mathieu, J., Clarençon, D., Agay, D., Chancerelle, Y., & Multon, É. T. (2004) · BMC Immunology · doi:10.1186/1471-2172-5-3 · Cited by 316 · see citing works
Cholecystokinin—From Local Gut Hormone to Ubiquitous Messenger
Rehfeld, J. F. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00047 · Cited by 264 · see citing works
Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model
Lin, H., An, Y., Tang, H., & Wang, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00249 · Cited by 235 · see citing works
Housset, C., Chrétien, Y., Debray, D., & Chignard, N. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150050 · Cited by 171 · see citing works
Joyce, S. A., Shanahan, F., Hill, C., & Gahan, C. G. (2014) · Gut Microbes · doi:10.4161/19490976.2014.969986 · Cited by 139 · see citing works
Frontoni, S., Choi, S. B., Banduch, D., & Rossetti, L. (1991) · Diabetes · doi:10.2337/diab.40.5.568 · Cited by 130 · see citing works
Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic Disease
Xie, C., Huang, W., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021) · Nutrients · doi:10.3390/nu13041104 · Cited by 124 · see citing works
Pathophysiological connections between gallstone disease, insulin resistance, and obesity
Cortés, V., Francisco Barrera, M., & Nervi, F. O. (2019) · Obesity Reviews · doi:10.1111/obr.12983 · Cited by 112 · see citing works
Daily, J. W., & Park, S. (2022) · Cells · doi:10.3390/cells11030338 · Cited by 108 · see citing works
Self-citationImpact of diet and the bacterial microbiome on the mucous barrier and immune disorders
Alemao, C. A., Budden, K. F., Gomez, H. M., Rehman, S. F., Marshall, J. E., Shukla, S. D., Donovan, C., Forster, S. C., Yang, I. A., Keely, S., et al. (2020) · Allergy · doi:10.1111/all.14548 · Cited by 107 · see citing works
Modulation of the Gut Microbiota by Nutrients with Prebiotic and Probiotic Properties
Druart, C., Alligier, M., Salazar, N., Neyrinck, A. M., & Delzenne, N. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.005835 · Cited by 103 · see citing works
Long-term effects of cholecystectomy on bile acid metabolism
Kullak-Ublick, G. A., Paumgartner, G., & Berr, F. (1995) · Hepatology · doi:10.1002/hep.1840210109 · Cited by 102 · see citing works
Kwon, D., Kim, Y. S., Ryu, S., Cha, M.-R., Yon, G., Yang, H.-J., Kim, M. J., Kang, S., & Park, S. (2013) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.006 · Cited by 97 · see citing works
Self-citationLiang, H., Jiang, F., Cheng, R., Luo, Y., Wang, J., Luo, Z., Li, M., Shen, X. P., & He, F. (2020) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.20-0094 · Cited by 78 · see citing works
Li, B., Zhang, J., Chen, Y., Wang, Q., Li, Y., Wang, R., Wei, Y., You, Z., Li, Y., Miao, Q., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1946366 · Cited by 74 · see citing works
The Impact of Cholecystectomy on the Gut Microbiota: A Case-Control Study
Yoon, W. J., Kim, H., Park, E., Ryu, S., Chang, Y., Shin, H., Kim, H., & Yi, S. Y. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010079 · Cited by 69 · see citing works
Park, S., Hong, S. M., Lee, J. E., & Sung, S. R. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00434.2007 · Cited by 68 · see citing works
Self-citationPloton, M., Mazuy, C., Gheeraert, C., Dubois, V., Berthier, A., Dubois-Chevalier, J., Maréchal, X., Bantubungi, K., Diemer, H., Cianférani, S., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.022 · Cited by 63 · see citing works
Chen, Y., Wu, S., & Tian, Y. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.95 · Cited by 62 · see citing works
Wu, X., Unno, T., Kang, S., & Park, S. (2021) · Nutrients · doi:10.3390/nu13020495 · Cited by 57 · see citing works
Self-citationPark, S., Kim, D. S., Kang, E. S., Kim, D. B., & Kang, S. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00005.2018 · Cited by 54 · see citing works
Self-citationMouse models of gallstone disease
Wang, T. Y., Portincasa, P., Liu, M., Tso, P., & Wang, D. Q. ‐. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000417 · Cited by 42 · see citing works
Chitosan alleviated menopausal symptoms and modulated the gut microbiota in estrogen-deficient rats
Wu, X., Kim, M. J., Yang, H. J., & Park, S. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02382-2 · Cited by 42 · see citing works
Self-citationModulation of Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles
Zhang, B., Kuipers, F., de Boer, J. F., & Kuivenhoven, J. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010004 · Cited by 42 · see citing works
Cholecystectomy: a way forward and back to metabolic syndrome?
Garruti, G., Wang, D. Q. ‐., Ciaula, A. D., & Portincasa, P. (2018) · Laboratory Investigation · doi:10.1038/labinvest.2017.129 · Cited by 36 · see citing works
Sjöberg, B. G., Straniero, S., Angelin, B., & Rudling, M. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2016 · Cited by 32 · see citing works
Park, S., Yuan, H., Zhang, T., Wu, X., Huang, S. K., & Cho, S. M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111415 · Cited by 30 · see citing works
Self-citationYang, H., Zhang, T., Wu, X., Kim, M., Kim, Y.-H., Yang, E.-S., Yoon, Y., & Park, S. (2021) · Antioxidants · doi:10.3390/antiox10050756 · Cited by 30 · see citing works
Self-citationRyuk, J. A., Ko, B., Moon, N. R., & Park, S. (2022) · Antioxidants · doi:10.3390/antiox11010168 · Cited by 30 · see citing works
Self-citationLong-term effects of cholecystectomy on bile acid metabolism*1, *2
Kullak-Ublick, G. A. (1995) · Hepatology · doi:10.1016/0270-9139(95)90406-9 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota
Flaig, B., Garza, R., Singh, B., Hamamah, S., & Covașă, M. (2023) · Nutrients · doi:10.3390/nu15010228 · Cited by 64 · see citing works
Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention
Li, Q., & Chen, Y. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac659 · Cited by 49 · see citing works
Park, S., & Wu, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113574 · Cited by 46 · see citing works
Self-citationXu, F., Yu, Z., Liu, Y., Du, T., Yu, L., Tian, F., Chen, W., & Zhai, Q. (2023) · Nutrients · doi:10.3390/nu15173829 · Cited by 44 · see citing works
Zhang, L., Chen, N., Zhan, L., Bi, T., Zhou, W., Zhang, L., & Zhu, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116811 · Cited by 42 · see citing works
Park, S., Zhang, T., & Kang, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119533 · Cited by 35 · see citing works
Self-citationZhang, T., Wu, X., Yuan, H., Huang, S., & Park, S. (2022) · Cells · doi:10.3390/cells11152301 · Cited by 30 · see citing works
Self-citationNeuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota
Zhai, J., Li, Y., Liu, J., & Dai, C. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70329 · Cited by 30 · see citing works
The bile–gut axis and metabolic consequences of cholecystectomy
Lange, A. H., Pedersen, M. G., Ellegaard, A., Nerild, H. H., Brønden, A., Sonne, D. P., & Knop, F. K. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae034 · Cited by 26 · see citing works
Wu, X., & Park, S. (2022) · Biomedicines · doi:10.3390/biomedicines10112998 · Cited by 24 · see citing works
Self-citationZhang, S., Liu, R., Ma, Y., Ma, Y., Feng, H., Ding, X., Zhang, Q., Li, Y., Shan, J., Bian, H., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08232 · Cited by 19 · see citing works
Ye, Y., Ze, L., Duan, M., Tan, Z., Wang, Y., Zhang, H., & Shang, P. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.14417 · Cited by 18 · see citing works
Yuan, H., Zhou, J., Li, H., Kang, S., & Park, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146698 · Cited by 16 · see citing works
Self-citationDeng, M., Zhang, S., Wu, S., Jiang, Q., Teng, W., Luo, T., Ouyang, Y., Liu, J., & Gu, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1390293 · Cited by 15 · see citing works
Impact of cholecystectomy on the gut-liver axis and metabolic disorders
Raposo, M. A., Oliveira, E., Santos, A., Guadagnini, D., Mourabit, H. E., Housset, C., Lemoinne, S., & Saad, M. J. A. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102370 · Cited by 14 · see citing works
Park, S., Zhang, T., Yu, Y., Jeong, S.-J., Ryu, M.-S., Wu, X., Yang, H.-J., & Jeong, D. (2022) · Foods · doi:10.3390/foods11131951 · Cited by 13 · see citing works
Self-citationDeng, Z., Liu, M., Cao, K., Khalil, M. M., Guan, L. L., & Sun, L. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3063-5 · Cited by 12 · see citing works
Kaur, N., Kumar, P., Dhami, M., & Aran, K. R. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10425-2 · Cited by 13 · see citing works
Gao, Y., & Zhou, T. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104596 · Cited by 10 · see citing works
Chen, W., Xie, Y., Li, Q., Zhu, Z., Li, X., & Zhu, H. Y. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328371 · Cited by 10 · see citing works
Bile acids and gestational diabetes mellitus: exploring the link and implications - a review
Lu, C., Gao, Z., & Lei, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1574228 · Cited by 9 · see citing works
Fatima, S. N., Arif, F., Khalid, R., Khan, M., & Naseem, K. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107882 · Cited by 8 · see citing works
Meng, Z., Zhang, Q., Zhang, R., Liu, G., Xiang, W., He, Y., Zhang, Q., & Tang, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c07080 · Cited by 8 · see citing works
Lin, N., Chang, J., Li, X., Che, X., Sun, Y., Cui, W., & Xue, X. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1610560 · Cited by 5 · see citing works
O’Sullivan, D., Arora, T., Durif, C., Uriot, O., Brun, M., Riu, M., Foguet‐Romero, E., Samarra, I., Domingo-Almenara, X., Gahan, C. G. M., et al. (2024) · Nutrients · doi:10.3390/nu16132046 · Cited by 4 · see citing works
Host response to cholestyramine can be mediated by the gut microbiota
Newman, N. K., Monnier, P. M., Rodrigues, R. R., Gurung, M., Vasquez‐Perez, S., Hioki, K. A., Greer, R. L., Brown, K., Morgun, A., & Shulzhenko, N. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2023.82 · Cited by 4 · see citing works
Sundaram, S., Jagadeesan, A., Paulraj, R. S., Sundaram, U., & Arthur, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111452 · Cited by 4 · see citing works
Special Issue: “Gut Microbiota and Nutrition in Human Health”
Park, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111589 · Cited by 4 · see citing works
Self-citationPotential far‐reaching metabolic consequences of cholecystectomy
Khalil, M., Baffy, G., JohnBritto, J. S., Mitten, E. K., Ciaula, A. D., & Portincasa, P. (2026) · European Journal of Clinical Investigation · doi:10.1111/eci.70198 · Cited by 2 · see citing works
Wang, Y.-P. (2024) · American Journal of Translational Research · doi:10.62347/zfap9562 · Cited by 2 · see citing works
Xu, Y., Zhang, F., Ke, Z., Lin, Y., Zhang, Y., Liu, Y., Zhang, Y. Y., Xu, J., & Liu, Y. (2025) · Liver International · doi:10.1111/liv.70130 · Cited by 2 · see citing works
Li, Y., Niu, S., Wang, H. M., & Li, J. (2026) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2601.01007 · Cited by 1 · see citing works
Niv, D., Anavi, E., Yaval, L., Abbas, A., Rytwo, G., & Gutman, R. (2024) · Nutrients · doi:10.3390/nu16223958 · Cited by 1 · see citing works
Bile Acids and Gestational Diabetes Mellitus: Exploring the Link and ImplicationsPreprint
Lu, C., Gao, Z., & Lei, X. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4869474
Advances in the Study of the Relationship between Post-Cholecystectomy and NAFLD
杨, 艳. (2024) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2024.32083
Владимировна, Г. Е., Попкова, Т. В., Shalygina, M. V., & Gerasimova, D. A. (2024) · Gene Expression · doi:10.14218/ge.2024.00036
Murali, S., Krishnamurthy, N., Krishna, R. B. D., Vijayaraghavan, S., Kumar, R., & Francis, A. M. (2025) · Journal of Bio-X Research · doi:10.34133/jbioxresearch.0031
Sarı, İ., Bolat, H., Özmen, E., Köse, B., & Ayan, D. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgae175
Chen, H., Zhao, W., Yi, X., Gao, Q., Yang, X., Pang, K., Huang, B., & Liang, X. (2025) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2025.103057
Auerbach, E., Halpert, S., Fakiro, Y., Goliger, M., Hizami, G., Warman, M., Halabi, M., & Ganz, M. (2025) · Physician s Journal of Medicine · doi:10.55070/001c.134095
Liu, X.-Y., Ma, J., & Jiao, Y. (2025) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v17.i10.109359
Cholecystectomy for cholelithiasis – current understanding of its consequences (literature review)
Makarova, Y. V., Осипенко, М. Ф., Бикбулатова, Е. А., & Litvinova, N. V. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-25-54-59
Li, Y., Zhao, W., Zhan, K., Wang, L., Wang, F., Song, H., Zeng, F., Weng, Z., & Shen, X. (2025) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.5c00585
Li, Z., Zhang, F., & 孙晓毅 (2026) · The American Surgeon · doi:10.1177/00031348261419759
Hypocholesterolemic agents and the gut microbiota: a review of interactions and modulatory activity
Garcia, M. M. E., Xavier, V., Calhelha, R. C., & Heleno, S. A. (2026) · Pharmacological Reports · doi:10.1007/s43440-026-00874-2
Gut microbiota profiles and potential biomarkers in pre-pubertal females with ADHD
Bao, G., Tan, S., An, Y., & Luo, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1894383
The Bile Acid–Diet–Microbiome Axis in Clostridioides difficile Infection
Trofin, F., Buzilă, E. R., Iancu, I. R., Tuchiluş, C., Temneanu, O. R., Iancu, L. S., Vlad, M. A., Anton-Păduraru, D.-T., Armașu, I., Bădescu, A. C., et al. (2026) · Nutrients · doi:10.3390/nu18172872
- Authors
- Park, S., Zhang, T., Yue, Y., & Wu, X.
- Affiliations
- Hoseo University (KR)
- Obesity/Diabetes Research Center, Department of Food and Nutrition, Hoseo University, Asan 31499, Korea
- Corresponding author
- Park, Sunmin
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-05-25
- Volume
- 23
- Issue
- 11
- Pages
- 5935
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9180239
- OpenAlex
- W4281486453
- Cited by
- 47
- References
- 42
- Citations by year
- 2026: 6 · 2025: 18 · 2024: 14 · 2023: 4 · 2022: 5
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2019R1A2C1007203)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- bile acid metabolism, cholecystectomy, bile acid sequestrants, cholestyramine, dietary fat, high-fat diet, gut microbiota, energy metabolism, glucose metabolism, lipid metabolism, insulin resistance, serum lipids, liver inflammation, SREBP-1c, PPARγ, Akkermansia, Veillonella, obesity, gut-liver axis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Hypolipidemic Agents, Bile Acids and Salts, Cholecystectomy, Cholestyramine Resin, Dietary Fats, Glucose, Liver, Mice, Inbred C57BL, RNA, Messenger, Tumor Necrosis Factor-alpha, Weight Gain, Lipid Metabolism, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
