The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism
Open accessAbstract
BACKGROUND: As the gut microbiota contributes to metabolic health, it is important to determine specific diet-microbiota interactions that influence host metabolism. Bile acids and dietary fat source can alter phenotypes of diet-induced obesity, but the interplay with intestinal microorganisms is unclear. Here, we investigated metabolic consequences of diets enriched in primary bile acids with or without addition of lard or palm oil, and studied gut microbiota structure and functions in mice. RESULTS: In combination with bile acids, dietary lard fed to male C57BL/6N mice for a period of 8 weeks enhanced fat mass accumulation in colonized, but not in germ-free mice when compared to palm oil. This was associated with impaired glucose tolerance, lower fasting insulin levels, lower counts of enteroendocrine cells, fatty liver, and elevated amounts of hepatic triglycerides, cholesteryl esters, and monounsaturated fatty acids. Lard- and bile acid-fed mice were characterized by shifts in dominant gut bacterial communities, including decreased relative abundances of Lachnospiraceae and increased occurrence of Desulfovibrionaceae and the species Clostridium lactatifermentans and Flintibacter butyricus. Metatranscriptomic analysis revealed shifts in microbial functions, including lipid and amino acid metabolism. CONCLUSIONS: Caution is required when interpreting data from diet-induced obesity models due to varying effects of dietary fat source. Detrimental metabolic consequences of a diet enriched with lard and primary bile acids were dependent on microbial colonization of the host and were linked to hepatic lipid rearrangements and to alterations of dominant bacterial communities in the cecum.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The gut microbiota differs between mice fed diets that are high or low in fat and between diets that contain equal amounts of fat but from different sources.
“The gut microbiota has been shown to differ between mice fed diets that are high or low in fat and between diets that contain equal amounts of fat but from different sources [10–13] (Fig. 1).”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [11]
In a study combining lard or palm oil with dietary bile acids, lard enhanced fat mass accumulation, impaired glucose tolerance, and elevated levels of hepatic triglycerides in conventionally raised but not germ-free mice when compared to palm oil.
“In another study that combined lard or palm oil with dietary bile acids, lard enhanced fat mass accumulation, impaired glucose tolerance, and elevated levels of hepatic triglycerides in conventionally raised (CONV-R) but not in GF mice when compared to palm oil [11].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055 · see citing works
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/y59-099 · Cited by 23,189 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
Klindworth, A., Pruesse, E., Schweer, T., Peplies, J., Quast, C., Horn, M., & Glöckner, F. O. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks808 · Cited by 8,850 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Kozich, J. J., Westcott, S. L., Baxter, N. T., Highlander, S. K., & Schloss, P. D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01043-13 · Cited by 7,004 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data
Kopylova, E., Noé, L., & Touzet, H. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts611 · Cited by 3,051 · see citing works
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829 · see citing works
Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
Matyash, V., Liebisch, G., Kurzchalia, T. V., Shevchenko, A., & Schwudke, D. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d700041-jlr200 · Cited by 2,615 · see citing works
Self-citationHuman nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
Neuschwander-Tetri, B. A., Loomba, R., Sanyal, A. J., Lavine, J. E., Van Natta, M. L., Abdelmalek, M. F., Chalasani, N., Dasarathy, S., Diehl, A. M., Hameed, B., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61933-4 · Cited by 2,237 · see citing works
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works
Human gut microbes impact host serum metabolome and insulin sensitivity
Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., et al. (2016) · Nature · doi:10.1038/nature18646 · Cited by 2,116 · see citing works
Chun, J., Lee, J., Jung, Y., Kim, M., Kim, S., Kim, B. K., & Lim, Y. (2007) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.64915-0 · Cited by 2,096 · see citing works
Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR
Suzuki, M. T., & Giovannoni, S. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.2.625-630.1996 · Cited by 2,021 · see citing works
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931 · see citing works
The interaction between bacteria and bile
Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,793 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,398 · see citing works
den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., van Dijk, T. H., Oosterveer, M. H., Jonker, J. W., Groen, A. K., Reijngoud, D.-J., et al. (2015) · Diabetes · doi:10.2337/db14-1213 · Cited by 1,125 · see citing works
Jones, B. V., Begley, M., Hill, C., Gahan, C. G. M., & Marchesi, J. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804437105 · Cited by 1,098 · see citing works
Dumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042 · see citing works
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., Martin, P., Philippe, C., Walker, F., Bado, A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303816 · Cited by 1,001 · see citing works
Self-citationGodon, J., Zumstein, E., Dabert, P., Habouzit, F., & Moletta, R. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.7.2802-2813.1997 · Cited by 924 · see citing works
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
Islam, K. B. M. S., Fukiya, S., Hagio, M., Fujii, N., Ishizuka, S., Ooka, T., Ogura, Y., Hayashi, T., & Yokota, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.046 · Cited by 918 · see citing works
Brügger, B., Erben, G., Sandhoff, R., Wieland, F., & Lehmann, W. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2339 · Cited by 882 · see citing works
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
Rosshart, S. P., Vassallo, B. G., Angeletti, D., Hutchinson, D. S., Morgan, A. P., Takeda, K., Hickman, H. D., McCulloch, J. A., Badger, J. H., Ajami, N. J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.016 · Cited by 862 · see citing works
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Beyaz, S., Mana, M., Roper, J., Kedrin, D., Saadatpour, A., Hong, S., Bauer-Rowe, K. E., Xifaras, M. E., Akkad, A., Arias, E., et al. (2016) · Nature · doi:10.1038/nature17173 · Cited by 840 · see citing works
Shorthand notation for lipid structures derived from mass spectrometry
Liebisch, G., Vizcaíno, J. A., Köfeler, H. C., Trötzmüller, M., Griffiths, W. J., Schmitz, G., Spener, F., & Wakelam, M. J. O. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033506 · Cited by 833 · see citing works
Self-citationAn opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice
Fei, N., & Zhao, L.-P. (2012) · The ISME Journal · doi:10.1038/ismej.2012.153 · Cited by 713 · see citing works
Structural and functional roles of ether lipids
Dean, J. M., & Lodhi, I. J. (2017) · Protein & Cell · doi:10.1007/s13238-017-0423-5 · Cited by 682 · see citing works
High-fat diet alters gut microbiota physiology in mice
Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 680 · see citing works
Self-citationLooking for a Signal in the Noise: Revisiting Obesity and the Microbiome
Sze, M. A., & Schloss, P. D. (2016) · mBio · doi:10.1128/mbio.01018-16 · Cited by 600 · see citing works
Metabolism of Cholesterol and Bile Acids by the Gut Microbiota
Gérard, P. (2013) · Pathogens · doi:10.3390/pathogens3010014 · Cited by 580 · see citing works
Self-citationYutin, N., & Galperin, M. Y. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12173 · Cited by 569 · see citing works
Ussar, S., Griffin, N. W., Bézy, O., Fujisaka, S., Vienberg, S. G., Softic, S., Deng, L., Bry, L., Gordon, J. I., & Kahn, C. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.007 · Cited by 529 · see citing works
Barcoded Primers Used in Multiplex Amplicon Pyrosequencing Bias Amplification
Berry, D., Mahfoudh, K. B., Wagner, M., & Loy, A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05220-11 · Cited by 519 · see citing works
Han, J., Lin, K., Sequeira, C., & Borchers, C. H. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.11.015 · Cited by 516 · see citing works
A catalog of the mouse gut metagenome
Xiao, L., Feng, Q., Liang, S., Sonne, S. B., Xia, Z., Qiu, X., Li, X., Long, H., Zhang, J., Zhang, D., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3353 · Cited by 514 · see citing works
Lagkouvardos, I., Pukall, R., Abt, B., Foesel, B. U., Meier‐Kolthoff, J. P., Kumar, N., Bresciani, A., Martínez, I., Just, S., Ziegler, C., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.131 · Cited by 508 · see citing works
Self-citationLagkouvardos, I., Joseph, D., Kapfhammer, M., Giritli, S., Horn, M., Haller, D., & Clavel, T. (2016) · Scientific Reports · doi:10.1038/srep33721 · Cited by 498 · see citing works
Self-citationStructural resilience of the gut microbiota in adult mice under high-fat dietary perturbations
Zhang, C., Zhang, M. H., Pang, X., Zhao, Y., Wang, L., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2012.27 · Cited by 496 · see citing works
A biosynthetic pathway for a prominent class of microbiota-derived bile acids
Devlin, A. S., & Fischbach, M. A. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1864 · Cited by 448 · see citing works
Liebisch, G., Binder, M., Schifferer, R., Langmann, T., Schulz, B., & Schmitz, G. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.12.007 · Cited by 448 · see citing works
Self-citationHuman Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids
Haeusler, R. A., Astiarraga, B., Camastra, S., Accili, D., & Ferrannini, E. (2013) · Diabetes · doi:10.2337/db13-0639 · Cited by 444 · see citing works
Absence of intestinal microbiota does not protect mice from diet-induced obesity
Fleissner, C. K., Huebel, N., Abd El-Bary, M. M., Loh, G., Klaus, S., & Blaut, M. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510001303 · Cited by 436 · see citing works
Rhea: a transparent and modular R pipeline for microbial profiling based on 16S rRNA gene amplicons
Lagkouvardos, I., Fischer, S. E., Kumar, N., & Clavel, T. (2017) · PeerJ · doi:10.7717/peerj.2836 · Cited by 434 · see citing works
Self-citationde Wit, N., Derrien, M., Bosch-Vermeulen, H., Oosterink, E., Keshtkar, S., Duval, C., de Vogel-van den Bosch, J., Kleerebezem, M., Müller, M., & van der Meer, R. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2011 · Cited by 428 · see citing works
Shah, S. H., Crosslin, D. R., Haynes, C. S., Nelson, S. C., Turer, C. B., Stevens, R. D., Muehlbauer, M. J., Wenner, B. R., Bain, J. R., Laferrère, B., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2356-5 · Cited by 347 · see citing works
Liebisch, G., Lieser, B., Rathenberg, J., Drobnik, W., & Schmitz, G. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.09.003 · Cited by 336 · see citing works
Self-citationBile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice
Zheng, X., Huang, F., Zhao, A., Lei, S., Zhang, Y., Xie, G., Chen, T., Qu, C., Rajani, C., Dong, B., et al. (2017) · BMC Biology · doi:10.1186/s12915-017-0462-7 · Cited by 323 · see citing works
Liebisch, G., Drobnik, W., Reil, M., Trümbach, B., Arnecke, R., Olgemöller, B., Roscher, A., & Schmitz, G. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33398-8 · Cited by 296 · see citing works
Self-citationBerry, K. A. Z., & Murphy, R. C. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.07.009 · Cited by 279 · see citing works
Degradation of bile salts by human intestinal bacteria.
Hill, M. J., & Drašar, B. S. (1968) · Gut · doi:10.1136/gut.9.1.22 · Cited by 248 · see citing works
Lovejoy, J. C., Smith, S. R., Champagne, C. M., Most, M. M., LeFevre, M. L., DeLany, J. P., Denkins, Y. M., Rood, J. C., Veldhuis, J. D., & Bray, G. A. (2002) · Diabetes Care · doi:10.2337/diacare.25.8.1283 · Cited by 246 · see citing works
Clostridium ramosum Promotes High-Fat Diet-Induced Obesity in Gnotobiotic Mouse Models
Woting, A., Pfeiffer, N., Loh, G., Klaus, S., & Blaut, M. (2014) · mBio · doi:10.1128/mbio.01530-14 · Cited by 224 · see citing works
Martínez, I., Perdicaro, D. J., Brown, A. W., Hammons, S., Carden, T. J., Carr, T. P., Eskridge, K. M., & Walter, J. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.03046-12 · Cited by 215 · see citing works
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice
Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V. M., Schüppel, V. L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.001 · Cited by 211 · see citing works
Self-citationEcker, J., Scherer, M., Schmitz, G., & Liebisch, G. (2012) · Journal of Chromatography B · doi:10.1016/j.jchromb.2012.04.015 · Cited by 189 · see citing works
Self-citationDiagnosis and Assessment of NAFLD: Definitions and Histopathological Classification
Lackner, C., TINIAKOS, D. G., & Burt, A. D. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1562942 · Cited by 145 · see citing works
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology.
Perino, A., & Schoonjans, K. (2015) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 141 · see citing works
Huang, E. Y., Leone, V. A., Devkota, S., Wang, Y., Brady, M. J., & Chang, E. B. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486931 · Cited by 133 · see citing works
Wewalka, M., Patti, M., Barbato, C., Houten, S. M., & Goldfine, A. B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3367 · Cited by 130 · see citing works
Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism
Zhang, L., Xie, C., Nichols, R. G., Chan, S. H. J., Jiang, C., Hao, R., Smith, P. B. W., Cai, J., Simons, M., Hatzakis, E., et al. (2016) · mSystems · doi:10.1128/msystems.00070-16 · Cited by 126 · see citing works
Gonzales, E. M., Gerhardt, M. F., Fabrè, M., Setchell, K. D. R., Spraul, A., Vincent, I., Heubi, J. E., Bernard, O., & Jacquemin, E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.043 · Cited by 126 · see citing works
Lagkouvardos, I., Kläring, K., Heinzmann, S. S., Platz, S., Scholz, B., Engel, K., Schmitt‐Kopplin, P., Haller, D., Rohn, S., Skurk, T., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500125 · Cited by 122 · see citing works
Self-citationWegner, K., Just, S., Gau, L., Henrike, M., Gérard, P., Lepage, P., Clavel, T., & Rohn, S. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0048-1 · Cited by 119 · see citing works
Self-citationPfeiffer, N., Desmarchelier, C., Blaut, M., Daniel, H., Haller, D., & Clavel, T. (2012) · Archives of Microbiology · doi:10.1007/s00203-012-0822-1 · Cited by 105 · see citing works
Self-citationInteraction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism
Caesar, R., Nygrén, H., Orešič, M., & Bäckhed, F. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065847 · Cited by 93 · see citing works
Eisinger, K., Krautbauer, S., Hebel, T., Schmitz, G., Aslanidis, C., Liebisch, G., & Buechler, C. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.05.002 · Cited by 83 · see citing works
Self-citationZhang, L., Bahl, M. I., Roager, H. M., Fonvig, C. E., Hellgren, L. I., Frandsen, H. L., Pedersen, O. B., Holm, J., Hansen, T. F., & Licht, T. R. (2016) · The ISME Journal · doi:10.1038/ismej.2016.151 · Cited by 82 · see citing works
The mouse gut microbiome revisited: From complex diversity to model ecosystems
Clavel, T., Lagkouvardos, I., Blaut, M., & Stecher, B. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.03.002 · Cited by 77 · see citing works
Self-citationGilat, T., Leikin-Frenkel, A. I., Goldiner, I., Juhel, C., Lafont, H., Gobbi, D., & Konikoff, F. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50348 · Cited by 61 · see citing works
Gut barrier impairment by high-fat diet in mice depends on housing conditions.
Müller, V. M., Zietek, T., Rohm, F., Fiamoncini, J., Lagkouvardos, I., Haller, D., Clavel, T., & Daniel, H. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500775 · Cited by 57 · see citing works
Self-citationRolland, V., Dugail, I., Lièpvre, X. L., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1102 · Cited by 55 · see citing works
Aranias, T., Grosfeld, A., Poitou, C., Omar, A. A., Gall, M. L., Miquel, S., Garbin, K., Ribeiro, A., Bouillot, J., Bado, A., et al. (2015) · Journal of Nutritional Science · doi:10.1017/jns.2015.11 · Cited by 48 · see citing works
van der Wielen, P. W. J. J., Rovers, G. M. L. L., Scheepens, J. M. A., et al. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-3-921 · Cited by 47 · see citing works
Intestinal nutrient sensing and blood glucose control
Zietek, T., & Daniel, H. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000187 · Cited by 42 · see citing works
Bartram, J., Mountjoy, E., Brooks, T., Hancock, J., Williamson, H., Wright, G., Moppett, J., Goulden, N., & Hubank, M. (2016) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2016.02.008 · Cited by 37 · see citing works
Dugail, I., Quignard‐Boulangé, A., Bazin, R., et al. (1988) · Biochemical Journal · doi:10.1042/bj2540483 · Cited by 37 · see citing works
Ecker, J., Liebisch, G., Scherer, M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007906 · Cited by 28 · see citing works
Self-citationHypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice
Leikin-Frenkel, A. I., Parini, P., Konikoff, F. M., Benthin, L., Leikin-Gobbi, D., Goldiner, I., Einarsson, C., & Gilat, T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.12.005 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [5]Clavel T Desmarchelier C Haller D Gérard P Rohn S Lepage P Daniel H Intestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance Gut Microbes 2014 5 544 551 10.4161/gmic.29331 25003516 · DOI
- [81]Ridlon JM Alves JM Hylemon PB Bajaj JS Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship Gut Microbes 2013 4 382 387 10.4161/gmic.25723 23851335 PMC3839982 · DOI · Paper page
Cited by
Sorted by citations
Dietary lipids, gut microbiota and lipid metabolism
Schoeler, M., & Caesar, R. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09512-0 · Cited by 1,163 · see citing works
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481 · see citing works
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Han, H., Yi, B., Zhong, R., Wang, M., Zhang, S., Ma, J., Yin, Y., Yin, J., Chen, L., & Zhang, H. (2021) · Microbiome · doi:10.1186/s40168-021-01093-y · Cited by 292 · see citing works
Metabolic Messengers: bile acids
Perino, A., & Schoonjans, K. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00559-z · Cited by 223 · see citing works
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works
The Gut Microbiome and Individual-Specific Responses to Diet
Leshem, A., Segal, E., & Elinav, E. (2020) · mSystems · doi:10.1128/msystems.00665-20 · Cited by 109 · see citing works
Bile acids: Key players in inflammatory bowel diseases?
Kriaa, A., Mariaule, V., Jablaoui, A., Rhimi, S., Mkaouar, H., Hernandez, J., Korkmaz, B., Lesner, A., Maguin, E., Aghdassi, A., et al. (2022) · Cells · doi:10.3390/cells11050901 · Cited by 53 · see citing works
The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder
Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works
- Authors
- Just, S., Mondot, S., Ecker, J., Wegner, K., Rath, E., Gau, L., Streidl, T., Hery-Arnaud, G., Schmidt, S., Lesker, T. R., Bieth, V., Dunkel, A., Strowig, T., Hofmann, T., Haller, D., Liebisch, G., Gérard, P., Rohn, S., Lepage, P., & Clavel, T.
- Affiliations
- Technical University of Munich (DE)
- AgroParisTech (FR)
- Universität Hamburg (DE)
- Universitätsklinikum Aachen (DE)
- Helmholtz Centre for Infection Research (DE)
- University of Regensburg (DE)
- Corresponding author
- Clavel, Thomas
- ORCID
- Venue
- Microbiome
- Published
- 2018-08-02
- Volume
- 6
- Issue
- 1
- Pages
- 134-134
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC6091023
- OpenAlex
- W2887314767
- Cited by
- 269
- References
- 94
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 35 · 2023: 39 · 2022: 44 · 2021: 49 · 2020: 42 · 2019: 24 · 2018: 3
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion, other-oa)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen)
- Funders
- Deutsche Forschungsgemeinschaft (CL481/1-1, RO3477/9-1)
- Agence Nationale de la Recherche (ANR-13-ISV3-0008-04)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, primary bile acids, dietary fat source, lard, palm oil, diet-induced obesity, fat mass accumulation, glucose tolerance, insulin resistance, enteroendocrine cells, hepatic steatosis, hepatic lipid metabolism, Lachnospiraceae, Desulfovibrionaceae, microbial colonization, germ-free mice, cecal microbiota, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Palm Oil, Amino Acids, Animals, Bacteria, Bile Acids and Salts, Dietary Fats, DNA, Bacterial, DNA, Ribosomal, Male, Mice, Inbred C57BL, Obesity, Phylogeny, RNA, Ribosomal, 16S, Gene Expression Profiling, Lipid Metabolism, Mice, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
