Cited by 52Breast Cancer Treatment StudiesCancer Genomics and DiagnosticsBioinformatics and Genomic Networks

Omics Technologies Improving Breast Cancer Research and Diagnostics

Open access
Orsini, Arianna, Diquigiovanni, Chiara, Bonora, Elena·2023·International Journal of Molecular Sciences

Abstract

Breast cancer (BC) has yielded approximately 2.26 million new cases and has caused nearly 685,000 deaths worldwide in the last two years, making it the most common diagnosed cancer type in the world. BC is an intricate ecosystem formed by both the tumor microenvironment and malignant cells, and its heterogeneity impacts the response to treatment. Biomedical research has entered the era of massive omics data thanks to the high-throughput sequencing revolution, quick progress and widespread adoption. These technologies—liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, pharmaco-omics and artificial intelligence imaging—could help researchers and clinicians to better understand the formation and evolution of BC. This review focuses on the findings of recent multi-omics-based research that has been applied to BC research, with an introduction to every omics technique and their applications for the different BC phenotypes, biomarkers, target therapies, diagnosis, treatment and prognosis, to provide a comprehensive overview of the possibilities of BC research.

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Crossref · 10.3390/ijms241612690

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  • BRCA1 and USP44 have been reported to be of great interest in breast cancer, since BRCA1 is a tumor suppressor and USP44 still has unknown oncogenic potential.

    “For instance, BRCA1 and USP44 have been reported to be of great interest in breast cancer, since the first protein is a tumor suppressor, and the second one still has an unknown oncogenic potential.”

    From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [106]

    Section 3.1 (page unavailable) discusses BRCA1 silencing in sporadic breast cancer, supporting BRCA1's relevance to the disease. It does not identify BRCA1 as a tumor suppressor, and searches for USP44 and its oncogenic potential found no passage addressing either point. (LLM, conf=0.82)

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Authors
Orsini, A., Diquigiovanni, C., & Bonora, E.
Affiliations
University of Bologna (IT)
Corresponding author
Diquigiovanni, Chiara
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-08-11
Volume
24
Issue
16
Pages
12690
ISSN
1422-0067 (ISSN-L)
OpenAlex
W4385769695
Cited by
52
References
201
Citations by year
2026: 10 · 2025: 26 · 2024: 15 · 2023: 1
FWCI
1.64
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
breast cancer, multi-omics, liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, tumor microenvironment, tumor heterogeneity, biomarkers, targeted therapy, prognosis, diagnosis
MeSH terms
Artificial Intelligence, Humans, Neoplasms, Research Personnel, Ecosystem, Biomedical Research, Epigenomics

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