Omics Technologies Improving Breast Cancer Research and Diagnostics
Open accessAbstract
Breast cancer (BC) has yielded approximately 2.26 million new cases and has caused nearly 685,000 deaths worldwide in the last two years, making it the most common diagnosed cancer type in the world. BC is an intricate ecosystem formed by both the tumor microenvironment and malignant cells, and its heterogeneity impacts the response to treatment. Biomedical research has entered the era of massive omics data thanks to the high-throughput sequencing revolution, quick progress and widespread adoption. These technologies—liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, pharmaco-omics and artificial intelligence imaging—could help researchers and clinicians to better understand the formation and evolution of BC. This review focuses on the findings of recent multi-omics-based research that has been applied to BC research, with an introduction to every omics technique and their applications for the different BC phenotypes, biomarkers, target therapies, diagnosis, treatment and prognosis, to provide a comprehensive overview of the possibilities of BC research.
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BRCA1 and USP44 have been reported to be of great interest in breast cancer, since BRCA1 is a tumor suppressor and USP44 still has unknown oncogenic potential.
“For instance, BRCA1 and USP44 have been reported to be of great interest in breast cancer, since the first protein is a tumor suppressor, and the second one still has an unknown oncogenic potential.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [106]
Section 3.1 (page unavailable) discusses BRCA1 silencing in sporadic breast cancer, supporting BRCA1's relevance to the disease. It does not identify BRCA1 as a tumor suppressor, and searches for USP44 and its oncogenic potential found no passage addressing either point. (LLM, conf=0.82)
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Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
Bolyen, E., Rideout, J. R., Dillon, M. R., Bokulich, N. A., Abnet, C. C., Al-Ghalith, G. A., Alexander, H., Alm, E. J., Arumugam, M., Asnicar, F., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0209-9 · Cited by 23,742 · see citing works
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies
Whiting, P. F., Rutjes, A. W. S., Westwood, M. E., Mallett, S., Deeks, J. J., Reitsma, J. B., Leeflang, M. M. G., Sterne, J. A. C., Bossuyt, P. M. M., & the QUADAS-2 Group* (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-8-201110180-00009 · Cited by 14,199 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Lehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., & Pietenpol, J. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45014 · Cited by 5,592 · see citing works
Foulkes, W. D., Smith, I. E., & Reis-Filho, J. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmra1001389 · Cited by 4,719 · see citing works
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,122 · see citing works
Metabolomics: beyond biomarkers and towards mechanisms
Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.25 · Cited by 2,829 · see citing works
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., et al. (2018) · Science · doi:10.1126/science.aar3247 · Cited by 2,783 · see citing works
Alpelisib for <i>PIK3CA</i> -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
André, F., Ciruelos, E., Rubovszky, G., Campone, M., Loibl, S., Rugo, H. S., Iwata, H., Conte, P., Mayer, I. A., Kaufman, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813904 · Cited by 2,622 · see citing works
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Azizi, E., Carr, A. J., Plitas, G., Cornish, A. E., Konopacki, C., Prabhakaran, S., Nainys, J., Wu, K., Kiseliovas, V., Setty, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.060 · Cited by 1,976 · see citing works
Cristofanilli, M., Turner, N. C., Bondarenko, I., Ro, J., Im, S.-A., Masuda, N., Colleoni, M., DeMichele, A., Loi, S., Verma, S., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00613-0 · Cited by 1,827 · see citing works
A single-cell and spatially resolved atlas of human breast cancers
Wu, S. Z., Al-Eryani, G., Roden, D. L., Junankar, S., Harvey, K., Andersson, A., Thennavan, A., Wang, C., Torpy, J. R., Bartonicek, N., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00911-1 · Cited by 1,775 · see citing works
Huang, Y., Liang, C., He, L., Tian, J., Liang, C., Chen, X., Ma, Z., & Liu, Z. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.9128 · Cited by 1,745 · see citing works
Ten years of next-generation sequencing technology
van Dijk, E., Auger, H., Jaszczyszyn, Y., & Thermes, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.07.001 · Cited by 1,632 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence
Bleyer, A., & Welch, H. G. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1206809 · Cited by 1,371 · see citing works
Metabolomics for Investigating Physiological and Pathophysiological Processes
Wishart, D. S. (2019) · Physiological Reviews · doi:10.1152/physrev.00035.2018 · Cited by 1,247 · see citing works
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Kim, C. R., Gao, R., Sei, E., Brandt, R., Hartman, J., Hatschek, T., Crosetto, N., Foukakis, T., & Navin, N. E. (2018) · Cell · doi:10.1016/j.cell.2018.03.041 · Cited by 1,091 · see citing works
Hayes, D. F., Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Miller, M. C., Matera, J., Allard, W. J., Doyle, G. V., & Terstappen, L. W. M. M. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2821 · Cited by 1,032 · see citing works
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
Chung, W., Eum, H. H., Lee, H.-O., Lee, K.-M., Lee, H.-B., Kim, K.-T., Ryu, H. S., Kim, S., Lee, J. E., Park, Y. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15081 · Cited by 992 · cited 1× · see citing works
“To understand the complexity of the tumor immune microenvironment (TIME), specific studies have been conducted on tissue-resident memory T and B cells [73,74], allowing a better understanding of the general characteristics of immune cells in BC, revealing the vast diversity in the immune cells of both the adaptive and…”
BackgroundKathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Savas, P., Virassamy, B., Ye, C., Salim, A., Mintoff, C. P., Caramia, F., Salgado, R., Byrne, D. J., Teo, Z. L., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0078-7 · Cited by 992 · see citing works
Liquid Biopsy: From Discovery to Clinical Application
Alix‐Panabières, C., & Pantel, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1311 · Cited by 983 · see citing works
The single-cell pathology landscape of breast cancer
Jackson, H. W., Fischer, J. R., Zanotelli, V. R., Ali, H. R., Mechera, R., Soysal, S. D., Moch, H., Muenst, S. E., Varga, Z., Weber, W. P., et al. (2020) · Nature · doi:10.1038/s41586-019-1876-x · Cited by 891 · see citing works
Bidard, F., Peeters, D. J. E., Fehm, T. N., Nolè, F., Gisbert‐Criado, R., Mavroudis, D., Grisanti, S., Generali, D., García-Sáenz, J. Á., Stebbing, J., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70069-5 · Cited by 842 · see citing works
Ciatto, S., Houssami, N., Bernardi, D., Caumo, F., Pellegrini, M., Brunelli, S., Tuttobene, P., Bricolo, P., Fantò, C., Valentini, M., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70134-7 · Cited by 838 · see citing works
Bartoschek, M., Oskolkov, N., Bocci, M., Lövrot, J., Larsson, C., Sommarin, M., Madsen, C. D., Lindgren, D., Pekar, G., Karlsson, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07582-3 · Cited by 826 · see citing works
Metabolomics in cancer research and emerging applications in clinical oncology
Schmidt, D. R., Patel, R., Kirsch, D. G., Lewis, C. A., Heiden, M. G. V., & Locasale, J. W. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21670 · Cited by 652 · see citing works
Circulating Tumor Cells and Response to Chemotherapy in Metastatic Breast Cancer: SWOG S0500
Smerage, J. B., Barlow, W. E., Hortobágyi, G. N., Winer, E. P., Leyland-Jones, B. R., Srkalović, G., Tejwani, S., Schott, A. F., O’Rourke, M. A., Lew, D. L., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.2561 · Cited by 649 · see citing works
Li, S., Shen, D., Shao, J., Crowder, R. J., Liu, W., Prat, A., He, X., Liu, S., Hoog, J., Lu, C., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.022 · Cited by 623 · see citing works
Circulating Tumor Cells Predict Survival in Early Average-to-High Risk Breast Cancer Patients
Rack, B., Schindlbeck, C., Jückstock, J., Andergassen, U., Hepp, P., Zwingers, T., Friedl, T. W. P., Lorenz, R., Tesch, H., Fasching, P. A., et al. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju066 · Cited by 615 · see citing works
Metabolic barriers to cancer immunotherapy
DePeaux, K., & Delgoffe, G. M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00541-y · Cited by 614 · see citing works
A pan-cancer proteomic perspective on The Cancer Genome Atlas
Akbani, R., Ng, P. K. S., Werner, H. M. J., Shahmoradgoli, M., Zhang, F., Ju, Z., Liu, W., Yang, J.-Y., Yoshihara, K., Li, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4887 · Cited by 600 · see citing works
Applications of single-cell sequencing in cancer research: progress and perspectives
Lei, Y., Tang, R., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01105-2 · Cited by 597 · see citing works
Schiavon, G., Hrebien, S., García-Murillas, I., Cutts, R. J., Pearson, A., Tarazona, N., Fenwick, K., Kozarewa, I., López‐Knowles, E., Ribas, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7551 · Cited by 589 · see citing works
Hilvo, M., Denkert, C., Lehtinen, L., Müller, B. M., Brockmöller, S. F., Seppänen‐Laakso, T., Budczies, J., Bucher, E., Yetukuri, L., Castillo, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3894 · Cited by 532 · see citing works
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Krug, K., Jaehnig, E. J., Satpathy, S., Blumenberg, L. M., Karpova, A. Y., Anurag, M., Miles, G., Mertins, P., Geffen, Y., Tang, L. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.036 · Cited by 532 · see citing works
Circulating tumour cells in non-metastatic breast cancer: a prospective study
Lucci, A., Hall, C. S., Lodhi, A., Bhattacharyya, A., Anderson, A. E., Xiao, L., Bedrosian, I., Kuerer, H. M., & Krishnamurthy, S. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70209-7 · Cited by 507 · see citing works
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
He, X., Liu, X., Zuo, F., Shi, H., & Jing, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.009 · Cited by 474 · see citing works
MRI for breast cancer screening, diagnosis, and treatment
Morrow, M., Waters, J., & Morris, E. A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61350-0 · Cited by 450 · see citing works
Luminal B Breast Cancer: Molecular Characterization, Clinical Management, and Future Perspectives
Ades, F., Zardavas, D., Božović‐Spasojević, I., Pugliano, L., Fumagalli, D., de Azambuja, E., Viale, G., Sotiriou, C. P., & Piccart, M. J. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.1870 · Cited by 441 · see citing works
O’Leary, B., Hrebien, S., Morden, J. P., Beaney, M., Fribbens, C. V., Huang, X., Liu, Y., Bartlett, C. H., Koehler, M. T., Cristofanilli, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03215-x · Cited by 418 · see citing works
Andersson, A., Larsson, L., Stenbeck, L., Salmén, F., Ehinger, A., Wu, S. Z., Al-Eryani, G., Roden, D., Swarbrick, A., Borg, Å., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26271-2 · Cited by 404 · see citing works
Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer
Velazquez, E. R., Parmar, C., Liu, Y., Coroller, T. P., Cruz, G., Stringfield, O., Ye, Z., Makrigiorgos, M. G., Fennessy, F., Mak, R. H., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0122 · Cited by 391 · see citing works
Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer
Janni, W., Rack, B. K., Terstappen, L. W. M. M., Pierga, J., Taran, F., Fehm, T. N., Hall, C. S., de Groot, M. R., Bidard, F., Friedl, T. W. P., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1603 · Cited by 363 · see citing works
Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?
Gires, O., Pan, M., Schinke, H., Canis, M., & Baeuerle, P. A. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09898-3 · Cited by 355 · see citing works
Bao, Y., Wang, L., Shi, L., Yun, F., Liu, X., Chen, Y., Chen, C., Ren, Y., & Jia, Y. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0162-0 · Cited by 354 · see citing works
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer
Xiao, Y., Ma, D., Yang, Y., Yang, F., Ding, J.-H., Gong, Y., Jiang, L., Ge, L., Wu, S., Yu, Q., et al. (2022) · Cell Research · doi:10.1038/s41422-022-00614-0 · Cited by 330 · see citing works
Lin, W., Noel, P., Borazanci, E. H., Lee, J., Amini, A., Han, I. W., Heo, J. S., Jameson, G., Fraser, C. R., Steinbach, M. A., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00776-9 · Cited by 328 · see citing works
Widschwendter, M., Siegmund, K. D., Müller, H. M., Fiegl, H., Marth, C., Müller‐Holzner, E., Jones, P. A., & Laird, P. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3852 · Cited by 322 · see citing works
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
Baldominos, P., Barbera-Mourelle, A., Barreiro, O., Huang, Y., Wight, A. E., Cho, J.-W., Zhao, X., Estivill, G., Adam, I., Sanchez, X., et al. (2022) · Cell · doi:10.1016/j.cell.2022.03.033 · Cited by 315 · see citing works
McDonald, B. R., Contente‐Cuomo, T., Sammut, S., Odenheimer-Bergman, A., Ernst, B. J., Perdigones, N., Chin, S., Farooq, M., Mejia, R., Cronin, P. A., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax7392 · Cited by 306 · see citing works
Transcriptome Profiling in Human Diseases: New Advances and Perspectives
Casamassimi, A., Federico, A., Rienzo, M., Esposito, S., & Ciccodicola, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081652 · Cited by 288 · see citing works
Tzeng, A., Sangwan, N., Jia, M. R., Liu, C.-C., Keslar, K. S., Downs-Kelly, E. P., Fairchild, R. L., Al‐Hilli, Z., Grobmyer, S. R., & Eng, C. (2021) · Genome Medicine · doi:10.1186/s13073-021-00874-2 · Cited by 279 · see citing works
Shen, Y., Shamout, F. E., Oliver, J. R., Witowski, J. S., Kannan, K., Park, J., Wu, N., Huddleston, C., Wolfson, S., Millet, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26023-2 · Cited by 278 · see citing works
Bernardi, D., Macaskill, P., Pellegrini, M., Valentini, M., Fantò, C., Ostillio, L., Tuttobene, P., Luparia, A., & Houssami, N. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30101-2 · Cited by 275 · see citing works
Integrative Methods and Practical Challenges for Single-Cell Multi-omics
Ma, A., McDermaid, A., Xu, J., Chang, Y., & Ma, Q. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.02.013 · Cited by 272 · see citing works
Fackler, M. J., McVeigh, M., Mehrotra, J., Blum, M. A., Lange, J. R., Lapides, A., Garrett, E., Argani, P., & Sukumar, S. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3341 · Cited by 270 · see citing works
Ding, S., Chen, X., & Shen, K. (2020) · 癌症:英文版 · doi:10.1002/cac2.12078 · Cited by 267 · see citing works
Ulz, P., Perakis, S. O., Zhou, Q. X., Moser, T., Belic, J., Lazzeri, I., Wölfler, A., Zebisch, A., Gerger, A., Pristauz, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12714-4 · Cited by 265 · see citing works
Ultrasound for Breast Cancer Detection Globally: A Systematic Review and Meta-Analysis
Sood, R., Rositch, A. F., Shakoor, D., Ambinder, E. B., Pool, K.-L., Pollack, E. B., Mollura, D. J., Mullen, L. A., & Harvey, S. C. (2019) · Journal of Global Oncology · doi:10.1200/jgo.19.00127 · Cited by 261 · see citing works
Marinovich, M. L., Hunter, K. E., Macaskill, P., & Houssami, N. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy121 · Cited by 250 · see citing works
Salemme, V., Centonze, G., Cavallo, F., Defilippi, P., & Conti, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.610303 · Cited by 249 · see citing works
Digital Breast Tomosynthesis: Concepts and Clinical Practice
Chong, A., Weinstein, S. P., McDonald, E. S., & Conant, E. F. (2019) · Radiology · doi:10.1148/radiol.2019180760 · Cited by 244 · see citing works
Insight into the heterogeneity of breast cancer through next-generation sequencing
Russnes, H. G., Navin, N. E., Hicks, J. B., & Børresen‐Dale, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57088 · Cited by 240 · see citing works
Jerevall, P.-L., Ma, X.-J., Li, H., Salunga, R. C., Kesty, N. C., Erlander, M. G., Sgroi, D. C., Holmlund, B., Skoog, L. K., Fornander, T., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.145 · Cited by 220 · see citing works
The Proteomic Landscape of Triple-Negative Breast Cancer
Lawrence, R., Perez, E. M., Hernández, D., Miller, C. P., Haas, K. M., Irie, H. Y., Lee, S., Blau, C. A., & Villén, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.050 · Cited by 219 · see citing works
Clinical and translational values of spatial transcriptomics
Zhang, L., Chen, D., Song, D., Liu, X., Zhang, Y., Xu, X., & Wang, X. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00960-w · Cited by 212 · see citing works
Hu, Q., Hong, Y., Qi, P., Lu, G., Mai, X., Xu, S., He, X., Guo, Y., Gao, L., Jing, Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22300-2 · Cited by 201 · see citing works
Zhao, S., Ma, D., Xiao, Y., Li, X., Ma, J., Zhang, H., Xu, X., Lv, H., Jiang, W., Yang, W.-T., et al. (2020) · The Oncologist · doi:10.1634/theoncologist.2019-0982 · Cited by 199 · see citing works
Metabolic crosstalk in the breast cancer microenvironment
Dias, A. S., Almeida, C. R., Helguero, L. A., & Duarte, I. F. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.09.002 · Cited by 198 · see citing works
Ma, C. X., Bose, R., Gao, F., Freedman, R. A., Telli, M. L., Kimmick, G., Winer, E., Naughton, M., Goetz, M. P., Russell, C., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0900 · Cited by 193 · see citing works
Furuya, M., Horiguchi, J., Nakajima, H., Kanai, Y., & Oyama, T. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02151.x · Cited by 189 · see citing works
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment
Lin, X., Xiao, Z., Chen, T., Liang, S. H., & Guo, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00317 · Cited by 176 · see citing works
Veeck, J., Ropero, S., Setién, F., González‐Suárez, E., Osório, A., Benitez, J. J., Herman, J. G., & Esteller, M. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.1010 · Cited by 173 · see citing works
Xu, K., Wang, R., Xie, H., Hu, L., Wang, C., Xu, J., Zhu, C., Liu, Y., Gao, F., Li, X., et al. (2021) · Oncogenesis · doi:10.1038/s41389-021-00355-6 · Cited by 166 · see citing works
Metabolomics: Moving to the Clinic
Nordström, A., & Lewensohn, R. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9156-4 · Cited by 164 · see citing works
Correlation between CpG methylation profiles and hormone receptor status in breast cancers
Feng, W., Shen, L., Wen, S., Rosen, D. G., Jelı́nek, J., Hu, X., Huan, S., Huang, M. L., Liu, J., Şahin, A. A., et al. (2007) · Breast Cancer Research · doi:10.1186/bcr1762 · Cited by 154 · see citing works
Madic, J., Kiialainen, A., Bidard, F., Birzele, F., Ramey, G., Leroy, Q., Frio, T. R., Vaucher, I., Raynal, V., Bernard, V., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29265 · Cited by 147 · see citing works
Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade
Torrejon, D. Y., Abril-Rodriguez, G., Champhekar, A. S., Tsoi, J., Campbell, K. M., Kalbasi, A., Parisi, G., Zaretsky, J. M., Garcia-Diaz, A., Puig-Saus, C., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1409 · Cited by 146 · see citing works
Targeting HER2 heterogeneity in breast cancer
Hamilton, E. P., Shastry, M., Shiller, S. M., & Ren, R. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102286 · Cited by 136 · see citing works
Madden, S. F., Clarke, C., Gaule, P., Aherne, S. T., O’Donovan, N., CLYNES, M. M., Crown, J. P., & Gallagher, W. M. (2013) · Breast Cancer Research · doi:10.1186/bcr3444 · Cited by 133 · see citing works
Prospective analysis of circulating metabolites and breast cancer in EPIC
His, M., Viallon, V., Dossus, L., Gicquiau, A., Achaintre, D., Scalbert, A., Ferrari, P., Romieu, I., Onland‐Moret, N. C., Weiderpass, E., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1408-4 · Cited by 130 · see citing works
Multivariate Modeling and Prediction of Breast Cancer Prognostic Factors Using MR Metabolomics
Giskeødegård, G. F., Grinde, M. T., Sitter, B., Axelson, D. E., Lundgren, S., Fjøsne, H. E., Dahl, S., Gribbestad, I. S., & Bathen, T. F. (2009) · Journal of Proteome Research · doi:10.1021/pr9008783 · Cited by 128 · see citing works
Asleh, K., Negri, G. L., Miko, S. E. S., Colborne, S., Hughes, C. S., Wang, X. Q., Gao, D., Gilks, C. B., Chia, S., Nielsen, T. O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28524-0 · Cited by 127 · see citing works
Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes
Messier, T., Gordon, J. A. R., Boyd, J. R., Tye, C. E., Browne, G., Stein, J. L., Lian, J. B., & Stein, G. S. (2016) · Oncotarget · doi:10.18632/oncotarget.6922 · Cited by 125 · see citing works
Liquid Biopsy in Breast Cancer: A Focused Review
Tay, T. K. Y., & Tan, P. H. (2020) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2019-0559-ra · Cited by 119 · see citing works
Circulating cell-free DNA-based epigenetic assay can detect early breast cancer
Uehiro, N., Sato, F., Pu, F., Tanaka, S., Kawashima, M., Kawaguchi, K., Sugimoto, M., Saji, S., & Toi, M. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0788-z · Cited by 117 · see citing works
Bassiouni, R., Idowu, M. O., Gibbs, L. D., Robila, V., Grizzard, P. J., Webb, M. G., Song, J., Noriega, A., Craig, D. W., & Carpten, J. D. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-2682 · Cited by 114 · see citing works
Overview of Artificial Intelligence in Breast Cancer Medical Imaging
Zheng, D., He, X., & Jing, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020419 · Cited by 113 · see citing works
Aujero, M., Gavenonis, S. C., Benjamin, R., Zhang, Z., & Holt, J. (2017) · Radiology · doi:10.1148/radiol.2017162674 · Cited by 113 · see citing works
Quantification of Free Circulating Tumor DNA as a Diagnostic Marker for Breast Cancer
Catarino, R., Ferreira, M. M. F., Rodrigues, H., Coelho, A., Nogal, A. B. D. S., de Sousa, A., & Medeiros, R. (2008) · DNA and Cell Biology · doi:10.1089/dna.2008.0744 · Cited by 111 · see citing works
Sunami, E., Shinozaki, M., Sim, M., Nguyen, S. L., Vu, A., Giuliano, A. E., & Hoon, D. S. �. (2008) · Breast Cancer Research · doi:10.1186/bcr2098 · Cited by 111 · see citing works
Cancer metabolites: promising biomarkers for cancer liquid biopsy
Wang, W., Rong, Z., Wang, G., Hou, Y., Yang, F., & Qiu, M. (2023) · Biomarker Research · doi:10.1186/s40364-023-00507-3 · Cited by 108 · see citing works
Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery
Denkert, C., Bucher, E., Hilvo, M., Salek, R. M., Orešič, M., Griffin, J. L., Brockmöller, S. F., Klauschen, F., Loibl, S., Barupal, D. K., et al. (2012) · Genome Medicine · doi:10.1186/gm336 · Cited by 101 · see citing works
Fan, Y., Zhou, X. Y., Xia, T., Chen, Z., Li, J., Liu, Q., Alolga, R. N., Chen, Y., Lai, M., Li, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7155 · Cited by 101 · see citing works
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors
Bernhardt, S., Bayerlová, M., Vetter, M., Wachter, A., Mitra, D., Hanf, V., Lantzsch, T., Uleer, C., Peschel, S., John, J., et al. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0905-7 · Cited by 101 · see citing works
Radiogenomic analysis reveals tumor heterogeneity of triple-negative breast cancer
Jiang, L., You, C., Xiao, Y., Wang, H., Su, G.-H., Xia, B., Zheng, R., Zhang, D., Jiang, Y., Gu, Y., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100694 · Cited by 101 · see citing works
Adipocyte mesenchymal transition contributes to mammary tumor progression
Zhu, Q., Zhu, Y., Hepler, C., Zhang, Q., Park, J., Gliniak, C. M., Henry, G. H., Crewe, C., Bu, D., Zhang, Z., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111362 · Cited by 99 · see citing works
Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer
Liu, S., Gao, Z., Wu, J., Zheng, H., Li, B., Sun, S., Meng, X., & Wu, Q. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01236-0 · Cited by 98 · see citing works
The Molecular Pathology of Hereditary Breast Cancer
Palacios, J., Robles‐Frías, M. J., Castilla, M. Á., López‐García, M. Á., & Benitez, J. J. (2008) · Pathobiology · doi:10.1159/000123846 · Cited by 95 · see citing works
Leithner, D., Mayerhoefer, M. E., Martinez, D. F., Jochelson, M. S., Morris, E. A., Thakur, S. B., & Pinker, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061853 · Cited by 95 · see citing works
Defining a metabolic landscape of tumours: genome meets metabolism
Nanda, C. S., Venkateswaran, S. V., Patani, N., & Yuneva, M. O. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0663-7 · Cited by 94 · see citing works
Irinotecan-induced mucositis is associated with changes in intestinal mucins
Stringer, A. M., Gibson, R. J., Logan, R. M., Bowen, J. M., Yeoh, A. S. J., Laurence, J., & Keefe, D. M. K. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0855-y · Cited by 92 · see citing works
Žúbor, P., Kubatka, P., Kajo, K., Daňková, Z., Poláček, H., Bielik, T., Kúdela, E., Samec, M., Líšková, A., Vlcakova, D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122878 · Cited by 91 · see citing works
Personalized medicine in breast cancer: pharmacogenomics approaches
Jeibouei, S., Akbari, M. E., Kalbasi, A., Aref, A. R., Ajoudanian, M., Rezvani, A., & Zali, H. (2019) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s167886 · Cited by 89 · see citing works
Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer
Giró‐Perafita, A., Palomeras, S., Lum, D. H., Blancafort, A., Viñas, G., Oliveras, G., Pérez-Bueno, F., Sarrats, A., Welm, A. L., & Puig, T. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3133 · Cited by 88 · see citing works
Ma, F., Guan, Y., Yi, Z., Chang, L., Li, Q., Chen, S., Zhu, W., Guan, X., Li, C., Qian, H., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32536 · Cited by 88 · see citing works
Sinicropi, D. V., Qu, K., Collin, F., Crager, M., Liu, M., Pelham, R. J., Pho, M., Rossi, A. D., Jeong, J., Scott, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040092 · Cited by 82 · see citing works
Giskeødegård, G. F., Lundgren, S., Sitter, B., Fjøsne, H. E., Postma, G., Buydens, L. M. C., Gribbestad, I. S., & Bathen, T. F. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2798 · Cited by 81 · see citing works
Omics-Based Investigations of Breast Cancer
Neagu, A.-N., Whitham, D., Bruno, P. S., Morrissiey, H., Darie, C. A., & Darie, C. C. (2023) · Molecules · doi:10.3390/molecules28124768 · Cited by 79 · see citing works
CST6 promoter methylation in circulating cell-free DNA of breast cancer patients
Chimonidou, M., Tzitzira, A., Strati, A. D., Sotiropoulou, G., Sfikas, C., Malamos, N., Georgoulias, V., & Lianidou, E. S. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.09.015 · Cited by 78 · see citing works
Brockmöller, S. F., Bucher, E., Müller, B. M., Budczies, J., Hilvo, M., Griffin, J. L., Orešič, M., Kallioniemi, O., Iljin, K., Loibl, S., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200685r · Cited by 77 · see citing works
Woodard, G. A., Ray, K. M., Joe, B. N., & Price, E. R. (2017) · Radiology · doi:10.1148/radiol.2017162333 · Cited by 77 · see citing works
Zhou, S., Huang, Y., Liu, H., Zhou, X., Yuan, M., Hou, F., Wang, L., & Jiang, W. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.12.018 · Cited by 77 · see citing works
Zhong, L., Cheng, F., Lu, X., Duan, Y., & Wang, X. (2016) · Talanta · doi:10.1016/j.talanta.2016.04.049 · Cited by 76 · see citing works
Yamashita, Y., Nishiumi, S., Kono, S., Takao, S., Azuma, T., & Yoshida, M. (2017) · BMC Cancer · doi:10.1186/s12885-017-3554-4 · Cited by 75 · see citing works
Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease
Schwarzenbach, H., Müller, V., Milde‐Langosch, K., Steinbach, B., & Pantel, K. (2011) · Molecular BioSystems · doi:10.1039/c1mb05197k · Cited by 75 · see citing works
Oncotype DX Breast Recurrence Score®: A Review of its Use in Early-Stage Breast Cancer
Syed, Y. Y. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00482-7 · Cited by 75 · see citing works
Elevated level of cell-free plasma DNA is associated with breast cancer
Zhong, X. Y., Ladewig, A., Schmid, S. M., Wight, E., Hahn, S., & Holzgreve, W. (2007) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-007-0345-1 · Cited by 72 · see citing works
Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling
Yeh, A. C., Li, H., Zhu, Y., Zhang, J., Khramtsova, G. F., Drukker, K., Edwards, A. V., McGregor, S. M., Yoshimatsu, T. F., Zheng, Y., et al. (2019) · Cancer Imaging · doi:10.1186/s40644-019-0233-5 · Cited by 72 · see citing works
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
Myhre, S., Lingjærde, O. C., Hennessy, B. T., Aure, M. R. R., Carey, M. S., Alsner, J., Tramm, T., Overgaard, J., Mills, G. B., Børresen‐Dale, A., et al. (2013) · Molecular Oncology · doi:10.1016/j.molonc.2013.02.018 · Cited by 71 · see citing works
Epigenetic Regulation in Breast Cancer: Insights on Epidrugs
Kim, A., Mo, K., Kwon, H., Choe, S., Park, M., Kwak, W., & Yoon, H. (2023) · Epigenomes · doi:10.3390/epigenomes7010006 · Cited by 70 · see citing works
Szczepanek, J., Skorupa, M., Jarkiewicz‐Tretyn, J., Cybulski, C., & Tretyn, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087235 · Cited by 70 · see citing works
Baslan, T., Kendall, J., Volyanskyy, K. Y., McNamara, K. L., Cox, H., D'Italia, S., Ambrosio, F. J., Riggs, M. G., Rodgers, L., Leotta, A., et al. (2020) · eLife · doi:10.7554/elife.51480 · Cited by 67 · see citing works
Proteomic patterns associated with response to breast cancer neoadjuvant treatment
Shenoy, A., Nataraj, N. B., Perry, G., Loayza‐Puch, F., Nagel, R., Marin, I., Balint, N., Moshe, N. B. B., Pavlovski, A., Barshack, I., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209443 · Cited by 66 · see citing works
de Kruijf, E. M., Bastiaannet, E., Rubertà, F., de Craen, A. J. M., Kuppen, P. J. K., Smit, V. T. H. B. M., van de Velde, C. J. �., & Liefers, G. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.03.022 · Cited by 65 · see citing works
Circulating tumor cells before and during follow-up after breast cancer surgery
van Dalum, G., STAM, G. J. V. D., Tibbe, A. G. J., Franken, B., MASTBOOM, W. J. B., VERMES, I., de Groot, M. R., & Terstappen, L. W. M. M. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2694 · Cited by 65 · see citing works
MammaPrint guides treatment decisions in breast Cancer: results of the IMPACt trial
Soliman, H., Shah, V., Srkalovic, G., Mahtani, R., Levine, E., Mavromatis, B., Srinivasiah, J., Kassar, M., Gabordi, R., Qamar, R., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-6534-z · Cited by 65 · see citing works
Deciphering metabolic rewiring in breast cancer subtypes
Ogrodzinski, M. P., Bernard, J. J., & Lunt, S. Y. (2017) · Translational research · doi:10.1016/j.trsl.2017.07.004 · Cited by 64 · see citing works
Jansen, R. W., van Amstel, P., Martens, R. M., Kooi, I. E., Wesseling, P., de Langen, A. J., Menke-Van der Houven van Oordt, C. W., Jansen, B. H. E., Moll, A. C., Dorsman, J. C., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24893 · Cited by 63 · see citing works
Urban, J. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338857 · Cited by 63 · see citing works
Pineda, B., Díaz‐Lagares, Á., Fidalgo, J. A. P., Burgués, O., González‐Barrallo, I., Crujeiras, A. B., Sandoval, J., Esteller, M., Lluch, A. M., & Eroles, P. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0626-0 · Cited by 60 · see citing works
Free Circulating Tumor DNA as a Diagnostic Marker for Breast Cancer
Hashad, D. I., Sorour, A., Ghazal, A. A. E. R., & Talaat, I. M. (2012) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21548 · Cited by 59 · see citing works
Ultrasound-Based Radiomics Analysis for Predicting Disease-Free Survival of Invasive Breast Cancer
Xiong, L., Chen, H., Tang, X., Chen, B., Jiang, X., Liu, L., Feng, Y., Liu, L., & Li, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.621993 · Cited by 57 · see citing works
Metabolomics of Breast Cancer: A Review
Subramani, R., Poudel, S., Smith, K. D., Estrada, A., & Lakshmanaswamy, R. (2022) · Metabolites · doi:10.3390/metabo12070643 · Cited by 56 · see citing works
Campone, M., Valo, I., Jézéquel, P., Moreau, M., Boissard, A., Campion, L., Loussouarn, D., Verrièle, V., Coqueret, O., & Guette, C. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.048967 · Cited by 56 · see citing works
The role of the bacterial microbiome in the treatment of cancer
Yu, Z., Xie, R., You, R., Liu, Y., Chen, X.-Y., Chen, M., & Huang, P.-Y. (2021) · BMC Cancer · doi:10.1186/s12885-021-08664-0 · Cited by 56 · see citing works
Davey, M. G., Davey, M. S., Boland, M. R., Ryan, É. J., Lowery, A., & Kerin, M. J. (2021) · European Journal of Radiology · doi:10.1016/j.ejrad.2021.109996 · Cited by 56 · see citing works
Suman, S., Sharma, R. K., Kumar, V., Sinha, N., & Shukla, Y. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.07.024 · Cited by 53 · see citing works
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
Yang, T., Yang, Y., & Wang, Y. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01098-2 · Cited by 53 · see citing works
The role of clonal communication and heterogeneity in breast cancer
Martín-Pardillos, A., Valls‐Chiva, A., Vargas, G. B., Hurtado, P., Piñeiro, R., Guijarro-Carrillo, P. J., Hümmer, S., Serrano, E., Rodríguez‐Casanova, A., Díaz‐Lagares, Á., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5883-y · Cited by 52 · see citing works
Mapping Breast Cancer Microenvironment Through Single-Cell Omics
Tan, Z., Chen, K., Sun, M., Yang, F., Wong, M., Wang, S., & Zheng, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.868813 · Cited by 52 · see citing works
Risk factors for anthracycline-associated cardiotoxicity
Reinbolt, R. E., Patel, R., Pan, X. J., Timmers, C. D., Pilarski, R., Shapiro, C. L., & Lustberg, M. B. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-3008-y · Cited by 50 · see citing works
Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma
Fornecker, L., Muller, L., Bertrand, F., Paul, N., Pichot, A., Herbrecht, R., Chenard, M., Mauvieux, L., Vallat, L. D., Bahram, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37273-4 · Cited by 48 · see citing works
Estrogen Receptor Mutations in Breast Cancer—New Focus on an Old Target
Segal, C. V., & Dowsett, M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0067 · Cited by 48 · see citing works
Tanabe, Y., Shimizu, C., Hamada, A., Hashimoto, K., Ikeda, K., Nishizawa, D., Hasegawa, J., Shimomura, A., Ozaki, Y., Tamura, N., et al. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3314-9 · Cited by 48 · see citing works
Dittrich, J., Becker, S., Hecht, M., & Ceglarek, U. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400121 · Cited by 47 · see citing works
Integrated Transcriptome and Pathway Analyses Revealed Multiple Activated Pathways in Breast Cancer
Vishnubalaji, R., Nair, V. S., Ouararhni, K., Elkord, E., & Alajez, N. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00910 · Cited by 46 · see citing works
Hertz, D. L., Roy, S., Jack, J., Motsinger‐Reif, A. A., Drobish, A. A., Clark, L. S., Carey, L., Dees, E. C., & McLeod, H. L. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2910-1 · Cited by 44 · see citing works
The Epigenomic Revolution in Breast Cancer
Dávalos, V., Martínez‐Cardús, A., & Esteller, M. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.07.002 · Cited by 43 · see citing works
Tumor-related Microbiome in the Breast Microenvironment and Breast Cancer
Wang, N., Sun, T., & Xu, J. (2021) · Journal of Cancer · doi:10.7150/jca.58986 · Cited by 42 · see citing works
Transient commensal clonal interactions can drive tumor metastasis
Amara, S. N.-A., Kuiken, H. J., Selfors, L. M., Butler, T. M., Leung, M. L., Leung, C. T., Kuhn, E. P., Kolarova, T. R., Hage, C., Ganesh, K. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19584-1 · Cited by 40 · see citing works
Fan, S., Shahid, M., Jin, P., Asher, A., & Kim, J. (2020) · Metabolites · doi:10.3390/metabo10040170 · Cited by 40 · see citing works
Digital breast tomosynthesis: Image acquisition principles and artifacts
Sujlana, P., Mahesh, M., Vedantham, S., Harvey, S. C., Mullen, L. A., & Woods, R. W. (2018) · Clinical Imaging · doi:10.1016/j.clinimag.2018.07.013 · Cited by 39 · see citing works
Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates
Bouyahya, A., Hachlafi, N. E., Aanniz, T., Bourais, I., Mechchate, H., Benali, T., Shariati, M. A., Burkov, P., Lorenzo, J. M., Wilairatana, P., et al. (2022) · Molecules · doi:10.3390/molecules27082568 · Cited by 38 · see citing works
Tokura, M., Nakayama, J., Prieto‐Vila, M., Shiino, S., Yoshida, M., Yamamoto, T., Watanabe, N., Takayama, S., Suzuki, Y., Okamoto, K., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0090 · Cited by 38 · see citing works
Personalized medicine in breast cancer: pharmacogenomics approaches
Jeibouei, S., Akbari, M. E., Kalbasi, A., Aref, A. R., Ajoudanian, M., Rezvani, A., & Zali, H. (2019) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 35 · see citing works
Personalized medicine in breast cancer: pharmacogenomics approaches
Jeibouei, S., Akbari, M. E., Kalbasi, A., Aref, A. R., Ajoudanian, M., Rezvani, A., & Zali, H. (2019) · Dove Medical Press (Taylor and Francis Group) · Cited by 35 · see citing works
Kim, N., Chung, W., Eum, H. H., Lee, H., & Park, W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217196 · Cited by 34 · see citing works
He, X., Gu, J., Zou, D., Yang, H., Zhang, Y., Ding, Y., & Teng, L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.708052 · Cited by 34 · see citing works
Fischer, S., Tahoun, M., Klaan, B., Thierfelder, K. M., Weber, M. D., Krause, B. J., Hakenberg, O. W., Fuellen, G., & Hamed, M. (2019) · Cancers · doi:10.3390/cancers11091293 · Cited by 33 · see citing works
Li, Y., Kong, X., Wang, Z., & Xuan, L. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17124 · Cited by 32 · see citing works
Mijnes, J., Tiedemann, J., Eschenbruch, J., Gasthaus, J., Bringezu, S., Bauerschlag, D., Maass, N., Arnold, N., Weimer, J. P., Anzeneder, T., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.27303 · Cited by 32 · see citing works
The 3′UTR signature defines a highly metastatic subgroup of triple-negative breast cancer
Wang, L., Hu, X., Wang, P., & Shao, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.10975 · Cited by 31 · see citing works
Barrón-Gallardo, C. A., García‐Chagollán, M., Morán-Mendoza, A. J., Delgadillo-Cristerna, R., Martínez-Silva, M. G., Aguilar‐Lemarroy, A., & Jave‐Suárez, L. F. (2022) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211068965 · Cited by 30 · see citing works
Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells
Tong, M., Deng, Z., Yang, M., Xu, C., Zhang, X., Zhang, Q., Liao, Y., Deng, X., Lv, D., Zhang, X., et al. (2018) · 癌症:英文版 · doi:10.1186/s40880-018-0326-8 · Cited by 25 · see citing works
Lee, H. W., Cho, H.-H., Joung, J., Jeon, H. G., Jeong, B. C., Jeon, S. S., Lee, H. M., Nam, D., Park, W., Kim, C. K., et al. (2020) · Cancers · doi:10.3390/cancers12040866 · Cited by 25 · see citing works
Minić, Z., Hüttmann, N., Poolsup, S., Li, Y., Susevski, V., Zaripov, E. A., & Berezovski, M. V. (2022) · Biomedicines · doi:10.3390/biomedicines10020408 · Cited by 25 · see citing works
Neagu, A.-N., Whitham, D., Seymour, L., Haaker, N., Pelkey, I., & Darie, C. C. (2023) · Proteomes · doi:10.3390/proteomes11020013 · Cited by 25 · see citing works
Multianalyte liquid biopsy to aid the diagnostic workup of breast cancer
Setayesh, S. M., Hart, O., Naghdloo, A., Higa, N., Nieva, J. J., Lu, J. M., Hwang, S. E., Wilkinson, K., Kidd, M., Anderson, A. K. L., et al. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00480-4 · Cited by 24 · see citing works
Epigenetic study of early breast cancer (EBC) based on DNA methylation and gene integration analysis
Zhang, W., Wang, H., Qi, Y., Li, S., & Geng, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-05486-3 · Cited by 24 · see citing works
Maria, R. M., Altei, W. F., Andricopulo, A. D., Becceneri, A. B., Cominetti, M. R., Venâncio, T., & Colnago, L. A. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.07.015 · Cited by 23 · see citing works
‘Breast Cancer Resistance Likelihood and Personalized Treatment Through Integrated Multiomics’
Mehmood, S., Faheem, M. Q., Ismail, H., Farhat, S. M., Ali, M., Younis, S., & Asghar, M. N. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.783494 · Cited by 22 · see citing works
Zhang, Y., Li, G., Bian, W., Bai, Y., He, S., Liu, Y., Liu, H., & Liu, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5986 · Cited by 22 · see citing works
Integration of multi-omics data reveals a novel hybrid breast cancer subtype and its biomarkers
Wang, Z., Li, X., Wen, X.-L., Wang, N., Guo, Y., Xu, Z., Fu, S.-H., Xiong, F.-F., Bai, J., Gao, X., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1130092 · Cited by 21 · see citing works
Role of MRI in screening, diagnosis and management of breast cancer
Swayampakula, A. K., Dillis, C., & Abraham, J. (2008) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.5.811 · Cited by 20 · see citing works
Integrated analysis of differentially expressed genes and pathways in triple-negative breast cancer
Peng, C., Ma, W., Xia, W., & Zheng, W. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6101 · Cited by 20 · see citing works
NSD3: Advances in cancer therapeutic potential and inhibitors research
Xiu, S., Chi, X., Jia, Z., Cheng, S., Zhang, X., Li, Q., Gao, T., Zhang, L., & Liu, Z. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115440 · Cited by 18 · see citing works
Huang, K. T., Mikeska, T., Li, J., Takano, E. A., Millar, E. K. A., Graham, P., Boyle, S. E., Campbell, I., Speed, T. P., Dobrovic, A., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1676-0 · Cited by 17 · see citing works
Semaan, S. M., Wang, X., Stewart, P. A., Marshall, A. G., & Sang, Q. A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.057 · Cited by 17 · see citing works
Mamtimin, B., Hizbulla, M., Kurbantay, N., You, L., Xinghai, Y., & Upur, H. (2014) · 中医杂志:英文版 · doi:10.1016/s0254-6272(14)60073-x · Cited by 17 · see citing works
Drug Metabolism for the Identification of Clinical Biomarkers in Breast Cancer
Costa, B., & Vale, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063181 · Cited by 16 · see citing works
Rodríguez‐Casanova, A., Costa‐Fraga, N., Carballeira, C. C., González-Conde, M., Abuín, C., Bao‐Caamano, A., García‐Caballero, T., Brozos-Vázquez, E., Rodríguez-López, C., Cebey-López, V., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1016955 · Cited by 15 · see citing works
Mouron, S. A., Bueno, M. J., Lluch, A. M., Manso, L., Calvo, I., Cortés, J., García-Sáenz, J. Á., Gil‐Gil, M., Martínez-Jáñez, N., Apala, J. V., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35065-z · Cited by 14 · see citing works
Effects of sulforaphane on breast cancer based on metabolome and microbiome
Cao, S., Hu, S., Jiang, P., Zhang, Z., Li, L., & Wu, Q. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3168 · Cited by 14 · see citing works
Are Estrogen Receptor Genomic Aberrations Predictive of Hormone Therapy Response in Breast Cancer?
Tabarestani, S., Motallebi, M., & Akbari, M. E. (2016) · Iranian Journal of Cancer Prevention · doi:10.17795/ijcp-6565 · Cited by 13 · see citing works
Tang, L., Li, T., Xie, J., Huo, Y., & Ye, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1158027 · Cited by 13 · see citing works
Response to W.C. Taylor, and C. Fiala and E.P. Diamandis
Liu, M., Oxnard, G. R., Klein, E. A., Swanton, C., & Seiden, M. V. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.06.008 · Cited by 13 · see citing works
Spatially Annotated Single Cell Sequencing for Unraveling Intratumor Heterogeneity
Smit, M. M., Feller, K. J., You, L., Storteboom, J., Begce, Y., Beerens, C. E. M. T., & Chien, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.829509 · Cited by 12 · see citing works
Ma, Y., Shan, D.-D., Wei, J., & Chen, A. (2021) · PubMed Central · Cited by 11 · see citing works
Aguilar, B. H., Abdilleh, K., & Acquaah-Mensah, G. K. (2022) · Cancer Genetics · doi:10.1016/j.cancergen.2022.11.001 · Cited by 10 · see citing works
Combination strategies to target metabolic flexibility in cancer
Krstić, J., Schindlmaier, K., & Prokesch, A. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.03.001 · Cited by 9 · see citing works
Lyon, D., Yao, Y., Garrett, T. J., Kelly, D. L., Cousin, L., & Archer, K. J. (2023) · BMC Women s Health · doi:10.1186/s12905-023-02355-7 · Cited by 8 · see citing works
Tesfaigzi, Y., & Süßmuth, R. (1989) · Journal of Dairy Research · doi:10.1017/s0022029900026327 · Cited by 3 · see citing works
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Srinivasan, D., Balakrishnan, R., Chauhan, A., Kumar, J., Girija, D. M., Shrestha, R., Shrestha, R., & Subbarayan, R. (2025) · MedComm · doi:10.1002/mco2.70333 · Cited by 38 · see citing works
Editorial: Heterogeneity in breast cancer: clinical and therapeutic implications
Carlino, F., Solinas, C., Orditura, M., Bisceglia, M. D., Pellegrino, B., & Diana, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1321654 · Cited by 24 · see citing works
Omran, M. M., Emam, M., Gamaleldin, M., Abushady, A. M., Elattar, M., & El-Hadidi, M. S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06662-5 · Cited by 22 · see citing works
Opee, S. A., Eva, A. A., Noor, A., Hasan, S. M., & Mridha, M. F. (2025) · Healthcare Technology Letters · doi:10.1049/htl2.12122 · Cited by 20 · see citing works
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Meza-Menchaca, T., Albores-Medina, A., Heredia-Mendez, A. J., Ruíz-May, E., Ricaño-Rodríguez, J., Gallegos-García, V., Esquivel, A., Vettoretti-Maldonado, G., & Campos-Parra, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147927 · Cited by 15 · see citing works
Jiang, B., Wu, Y., Chen, X., Jian, C., & Wang, W. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105160 · Cited by 13 · see citing works
Emerging Breast Cancer Subpopulations: Functional Heterogeneity Beyond the Classical Subtypes
Kotsifaki, A., Kalouda, G., Karalexis, E., Stathaki, M., Μεταξάς, Γ., & Armakolas, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311599 · Cited by 12 · see citing works
Yashaswini, C., Kiran, N. S., & Chatterjee, A. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01539-8 · Cited by 12 · see citing works
Naghib, S. M., Khorasani, M. A., Sharifianjazi, F., & Tavamaishvili, K. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118412 · Cited by 11 · see citing works
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Vellan, C. J., Islam, T., Silva, S. D., Taib, N. A. M., Prasanna, G., & Jayapalan, J. J. (2024) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2024.110776 · Cited by 11 · see citing works
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Velmurugan, S., Wankhar, D., Paramasivan, V., & Subbaraj, G. K. (2025) · Biocell · doi:10.32604/biocell.2025.065891 · Cited by 10 · see citing works
Mechanisms of traditional Chinese medicine overcoming of radiotherapy resistance in breast cancer
Zhao, X., Luo, T., Qiu, Y., Yang, Z., Wang, D., Wang, Z., Zeng, J., & Bi, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1388750 · Cited by 9 · see citing works
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Navarro, S. L., Williamson, B. D., Huang, Y., Gowda, G. A. N., Raftery, D., Tinker, L. F., Zheng, C., Beresford, S. A. A., Purcell, H. J., Djukovic, D., et al. (2024) · Metabolites · doi:10.3390/metabo14080463 · Cited by 8 · see citing works
Sirek, T., Król-Jatręga, K., Borawski, P., Zmarzły, N., Boroń, D., Ossowski, P., Nowotny-Czupryna, O., Boroń, K., Janiszewska-Bil, D., Mitka-Krysiak, E., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1515387 · Cited by 8 · see citing works
González, A. R., Acuña-Merchán, L. A., Alexander, J. A. A., Kaen, D., López-Correa, C., Martin, C. M., Attwill, A., Marinetti, T., Rocha, J. V., & Barrios, C. H. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22081220 · Cited by 8 · see citing works
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Vellan, C. J., Natesan, V., & Jayapalan, J. J. (2025) · Clinical Breast Cancer · doi:10.1016/j.clbc.2025.05.005 · Cited by 6 · see citing works
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Taki, . G., Shareef, A., Baldaniya, L., Oweis, R. J., Jyothi, S. R., Singh, U., Sahoo, S., Chauhan, A. S., Khazratov, A., Sameer, H. N., et al. (2025) · Journal of Investigative Medicine · doi:10.1177/10815589251366905 · Cited by 5 · see citing works
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Khalili‐Tanha, G., & Shoari, A. (2025) · BioTech · doi:10.3390/biotech14030075 · Cited by 4 · see citing works
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Mu, N., Yang, H., & Chen, Z. (2025) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2025.109179 · Cited by 4 · see citing works
Yan, Y., Li, Y.-B., Liang, H., Chen, D., Li, B., & Murshed, A. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010332329241119104430 · Cited by 4 · see citing works
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Shah, S., Samah, A. A., Madni, S. H. H., Hashim, S. Z. M., & Faheem, M. (2026) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2026.114237 · Cited by 3 · see citing works
Qin, S., Wei, T., Mo, J., Lu, L., Chai, X., Huang, Q.-Y., Qi, S., & Tan, G. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134393 · Cited by 3 · see citing works
RetractedYang, X. (2024) · American Journal of Translational Research · doi:10.62347/kjgs9928 · Cited by 2 · see citing works
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Prabhu, N., Vijayan, V., & Mythili, N. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07919-w · Cited by 2 · see citing works
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Manickavasagam, G., Mahendran, T. R., & Lim, V. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_223 · Cited by 2 · see citing works
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Umer, M. F., & Arshed, M. (2025) · Springer eBooks · doi:10.1007/978-981-97-9827-8_20 · Cited by 1 · see citing works
Abdullah, M., & Wah, Y. B. (2024) · Lecture notes on data engineering and communications technologies · doi:10.1007/978-981-97-0293-0_40 · Cited by 1 · see citing works
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Umer, M. F., & Arshed, M. (2025) · Springer eBooks · doi:10.1007/978-981-97-9827-8_19
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- Authors
- Orsini, A., Diquigiovanni, C., & Bonora, E.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Diquigiovanni, Chiara
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-08-11
- Volume
- 24
- Issue
- 16
- Pages
- 12690
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10454385
- OpenAlex
- W4385769695
- Cited by
- 52
- References
- 201
- Citations by year
- 2026: 10 · 2025: 26 · 2024: 15 · 2023: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- breast cancer, multi-omics, liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, tumor microenvironment, tumor heterogeneity, biomarkers, targeted therapy, prognosis, diagnosis
- MeSH terms
- Artificial Intelligence, Humans, Neoplasms, Research Personnel, Ecosystem, Biomedical Research, Epigenomics
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