Cited by 52Breast Cancer Treatment StudiesCancer Genomics and DiagnosticsBioinformatics and Genomic Networks

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Omics Technologies Improving Breast Cancer Research and Diagnostics

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Orsini, Arianna, Diquigiovanni, Chiara, Bonora, Elena·2023·International Journal of Molecular Sciences

DOI 10.3390/ijms241612690PMC PMC10454385

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Abstract

Breast cancer (BC) has yielded approximately 2.26 million new cases and has caused nearly 685,000 deaths worldwide in the last two years, making it the most common diagnosed cancer type in the world. BC is an intricate ecosystem formed by both the tumor microenvironment and malignant cells, and its heterogeneity impacts the response to treatment. Biomedical research has entered the era of massive omics data thanks to the high-throughput sequencing revolution, quick progress and widespread adoption. These technologies—liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, pharmaco-omics and artificial intelligence imaging—could help researchers and clinicians to better understand the formation and evolution of BC. This review focuses on the findings of recent multi-omics-based research that has been applied to BC research, with an introduction to every omics technique and their applications for the different BC phenotypes, biomarkers, target therapies, diagnosis, treatment and prognosis, to provide a comprehensive overview of the possibilities of BC research.

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Authors: Orsini, A., Diquigiovanni, C., & Bonora, E.
Affiliations: University of Bologna (IT)
Corresponding author: Diquigiovanni, Chiara
ORCID: Orsini, Arianna
Diquigiovanni, Chiara
Bonora, Elena
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2023-08-11
Volume: 24
Issue: 16
Pages: 12690
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms241612690
PMC: PMC10454385
OpenAlex: W4385769695
Cited by: 52
References: 201
Citations by year: 2026: 10 · 2025: 26 · 2024: 15 · 2023: 1
FWCI: 1.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: breast cancer, multi-omics, liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, tumor microenvironment, tumor heterogeneity, biomarkers, targeted therapy, prognosis, diagnosis
MeSH terms: Artificial Intelligence, Humans, Neoplasms, Research Personnel, Ecosystem, Biomedical Research, Epigenomics

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