Connectome analysis of brain functional network alterations in depressive patients with suicidal attempt
Open accessAbstract
Our study aimed to clarify the neuroimaging correlates of suicide attempt by comparing differences in functional magnetic resonance imaging (fMRI) among depressed suicide attempters, depressed patients without suicide attempt history, and healthy controls through comprehensive and novel fMRI analyses and methods in the same study population. The association between depression severity and aspects of the brain imaging was also discussed. Our study recruited 109 participants who were assigned to three groups: 33 depressed patients with suicide attempt (SA), 32 depressed patients without suicide attempt (NS), and 44 healthy controls (HC). All participants were scanned using a 3 T MRI imaging system to obtain resting-state functional images. In seed-based correlation analysis, we found altered functional connectivity in some brain regions of the SA compared with the NS or HC, especially in the hippocampus and thalamus. In the voxel-based analysis, our results showed differential activation and regional homogeneity of the temporal lobe and several brain regions in the SA compared with the NS and HC. We also found that some brain areas correlated with the Hamilton Depression Rating Scale (HAM-D), anxiety, and depression scores, especially in the frontal and temporal lobes. Graph theoretical analysis (GTA) and network-based statistical (NBS) analyses revealed different topological organization as well as slightly better global integration and worse local segregation of the brain network (i.e., more like a random network) in depressed participants compared with healthy participants. We concluded that the brain function of major depressive disorders with and without suicide attempts changed compared with healthy participants.
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Altered seed-based connectivity has been found in the hippocampus, thalamus, and temporal lobe as well as the inferior frontal, orbital, and parietal lobes.
“In addition, altered seed-based connectivity has been found in the hippocampus, thalamus, and temporal lobe (69) as well as the inferior frontal, orbital, and parietal lobes (75).”
From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [69]
These studies have mostly assessed suicide risk in larger clinical samples of participants diagnosed with mood disorders and other psychiatric conditions with which suicide is a comorbid phenotype, but rarely have they investigated suicide transdiagnostically.
“Finally, these studies have mostly assessed suicide risk in larger clinical samples of participants diagnosed with mood disorders (64–75) and other psychiatric conditions (76–79) with which suicide is a comorbid phenotype, but rarely have they investigated suicide transdiagnostically.”
From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [69]
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- Authors
- Weng, J.-C., Chou, Y.-S., Tsai, Y.-H., Lee, C.-T., Hsieh, M.-H., & Chen, V.
- Affiliations
- Chang Gung University (TW)
- Chung Shan Medical University (TW)
- Chung Shan Medical University Hospital (TW)
- Corresponding author
- Chen, Vincent
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2019-11-14
- Volume
- 8
- Issue
- 11
- Pages
- 1966
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC6912611
- OpenAlex
- W2989282846
- Cited by
- 33
- References
- 38
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 6 · 2021: 11 · 2020: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (NSC102-2314-B-182-068-MY3, MOST105-2314-B-182-028, and MOST106-2314-B-182-040-MY3)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- suicide attempts, major depressive disorder, functional connectivity, brain network topology, hippocampus, thalamus, regional homogeneity, temporal lobe activation, graph-theoretical analysis, depression severity, anxiety
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