Characteristics of intrinsic brain functional connectivity alterations in major depressive disorder patients with suicide behavior
Abstract
BACKGROUND: The intrinsic brain functional connectivity of suicide attempts in major depressive disorder (MDD) remains incompletely understood. PURPOSE: To investigate graph-theoretical based functional connectivity strength (FCS) alterations in MDD patients with suicidal behavior. STUDY TYPE: Prospective. SUBJECTS: Fifty medication-free MDD patients, with (suicide attempters, SA, N = 15) and without (non-attempters, nSA, N = 35) a history of a suicide attempt, and 37 healthy controls (HC). FIELD STRENGTH/SEQUENCE: Resting-state functional magnetic resonance imaging (fMRI) using a gradient-echo imaging sequence was acquired at 3.0 T. ASSESSMENT: For each individual, voxel-wise whole-brain functional network was constructed and graph-theoretical based FCS map was calculated. For each individual in two patient groups, the seed-based functional connectivity map was constructed. STATISTICAL TESTS: Non-parameter permutation tests, analysis of covariance, two-sample t-test, Chi-square test, and Pearson correlation analysis. A P value <0.05 was considered statistically significant. RESULTS: Relative to the HC group, two MDD patient groups showed significantly lower FCS in the left hippocampus, while nSA patients showed additionally lower FCS in more widespread regions (P < 0.05). Importantly, comparing to nSA patients, SA patients had significantly higher FCS in the right orbitofrontal cortex (OFC) and bilateral dorsomedial prefrontal cortex (dmPFC) (P < 0.05). Further seed-based functional connectivity analysis revealed that the right OFC exhibited significantly higher connectivity to right middle frontal gyrus and lower connectivity to the left anterior cingulate cortex and left calcarine sulcus, and the bilateral dmPFC had significantly higher connectivity to the left middle frontal gyrus and right inferior temporal gyrus in the SA patients than in the nSA patients (P < 0.05). DATA CONCLUSION: This study identified disconnections of the OFC and dmPFC which were putatively related to a higher risk of suicidal behavior in MDD patients, thus extended the understanding of suicidal behavior at a brain circuit level. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 3.
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Medial prefrontal cortex showing heterogeneous FCS alterations in our study was found to have both increased and decreased FCS in previous case-control studies.
“For example, the medial prefrontal cortex showing heterogenous FCS alterations in our study was found to have both increased and decreased FCS in previous case-control studies [47, 51-53].”
From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [53]
Recovery of increased DMN FCS has significant correlations with treatment response.
“Studies have found that the recovery of increased DMN FCS has significant correlations with the treatment response [53]”
From Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome (2023) · cites this paper as [53]
Cites
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · cited 1× · see citing works
“The DMN is a large-scale brain network of interacting brain regions which show lower levels of activity when people are engaged in a particular task like paying attention, but higher levels of activity when people are awake and not involved in any specific mental exercise.(30) Particularly, as an important part of DMN…”
BackgroundSpontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works
DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI
Yan (2010) · Frontiers in System Neuroscience · doi:10.3389/fnsys.2010.00013 · Cited by 3,475 · see citing works
(1997) · American Psychiatric Press eBooks · Cited by 3,056 · see citing works
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
Baumeister, R. F. (1990) · Psychological Review · doi:10.1037/0033-295x.97.1.90 · Cited by 1,919 · cited 1× · see citing works
“For instance, suicide has been posited to serve as an escape from awareness of self.(33) According to this model, outcomes that fall short of one’s standards and expectations for self are interpreted as personal inadequacies, which cause self-awareness to become painful and generate negative affect.”
BackgroundCastelli, F., Happe, F. G. E., Uta Frith, A., & Frith, C. (2000) · NeuroImage · doi:10.1006/nimg.2000.0612 · Cited by 1,299 · see citing works
Network Centrality in the Human Functional Connectome
Zuo, X., Ehmke, R. C., Mennes, M., Imperati, D., Castellanos, F. X., Sporns, O., & Milham, M. P. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr269 · Cited by 1,169 · see citing works
Nock, M. K., Hwang, I., Sampson, N. A., & Kessler, R. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.29 · Cited by 1,125 · see citing works
Elliott, R. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.308 · Cited by 887 · see citing works
Oquendo, M. A., Galfalvy, H., Russo, S., Ellis, S. P., Grunebaum, M. F., Burke, A., & Mann, J. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1433 · Cited by 605 · see citing works
Depression, Neuroimaging and Connectomics: A Selective Overview
Gong, Q., & Yong He, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.009 · Cited by 496 · see citing works
Self-citationResting-state functional connectivity in treatment-resistant depression
Lui, S., Wu, Q., Qiu, L., Yang, X., Kuang, W., Chan, R. C. K., Huang, X., Kemp, G. J., Mechelli, A., & Gong, Q. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10101419 · Cited by 336 · see citing works
Self-citationRichard-Devantoy, S., Berlim, M. T., & Jollant, F. (2014) · Psychological Medicine · doi:10.1017/s0033291713002304 · Cited by 324 · see citing works
Monkul, E. S., Hatch, J. P., Nicoletti, M. A., Spence, S., Brambilla, P., Lacerda, A. L. T., Sassi, R. B., Mallinger, A. G., Keshavan, M. S., & Soares, J. C. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001919 · Cited by 321 · see citing works
Saleem, K. S., Kondo, H., & Price, J. L. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21577 · Cited by 315 · see citing works
Oquendo, M. A., Placidi, G. P. A., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L. S., Cooper, T. B., Parsey, R. V., Van Heertum, R. L., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.14 · Cited by 313 · see citing works
Jollant, F., Lawrence, N. S., Olie, E., O'Daly, O., Malafosse, A., Courtet, P., & Phillips, M. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.027 · Cited by 312 · see citing works
Orbitofrontal cortex response to angry faces in men with histories of suicide attempts
Jollant, F., Lawrence, N. S., Giampietro, V., Brammer, M. J., Fullana, M. A., Drapier, D., Courtet, P., & Phillips, M. L. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081239 · Cited by 262 · see citing works
A systematic review of the relationship between rumination and suicidality
Morrison, R., & O'Connor, R. C. (2008) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.2008.38.5.523 · Cited by 231 · see citing works
Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Okada, G., Kunisato, Y., Yoshino, A., Ueda, K., Suzuki, S.-I., & Yamawaki, S. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst009 · Cited by 229 · see citing works
A review of resting-state fMRI and its use to examine psychiatric disorders
Canario, E., Chen, D. Y., & Biswal, B. B. (2021) · Psychoradiology · doi:10.1093/psyrad/kkab003 · Cited by 222 · see citing works
Dunn, R. T., Kimbrell, T. A., Ketter, T. A., Frye, M. A., Willis, M. W., Luckenbaugh, D. A., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01244-6 · Cited by 184 · see citing works
Pan, L. A., Hassel, S., Segreti, A. M., Nau, S. A., Brent, D. A., & Phillips, M. L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002966 · Cited by 183 · see citing works
Wang, L., Xia, M., Li, K., Zeng, Y., Su, Y., Dai, W., Zhang, Q., Jin, Z., Mitchell, P. B., Yu, X., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22663 · Cited by 166 · see citing works
Self-citationHigh-Field Magnetic Resonance Imaging of Suicidality in Patients With Major Depressive Disorder
Jia, Z., Huang, X., Wu, Q., Zhang, T., Lui, S., Zhang, J., Amatya, N., Kuang, W., Chan, R. C. K., Kemp, G. J., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101513 · Cited by 158 · see citing works
Self-citationCao, J., Chen, X., Chen, J., Ai, M., Gan, Y., Wang, W., Lv, Z., Zhang, S., Zhang, S., Wang, S., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.07.002 · Cited by 140 · see citing works
Jia, Z., Wang, Y., Huang, X., Kuang, W., Wu, Q., Lui, S., Sweeney, J., & Gong, Q. (2014) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.130023 · Cited by 132 · see citing works
Self-citationDu, L., Zeng, J., Liu, H., Tang, D., Meng, H., Li, Y., & Fu, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.027 · Cited by 129 · see citing works
Pan, L. A., Batezati-Alves, S. C., Almeida, J. R. C., Segreti, A., Akkal, D., Hassel, S., Lakdawala, S., Brent, D. A., & Phillips, M. L. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.03.018 · Cited by 127 · see citing works
Kang, S.-G., Na, K.-S., Choi, J.-W., Kim, J.-H., Son, Y.-D., & Lee, Y. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.029 · Cited by 110 · see citing works
A diffusion tensor imaging study of suicide attempters
Olvet, D. M., Peruzzo, D., Thapa-Chhetry, B., Sublette, M. E., Sullivan, G. M., Oquendo, M. A., Mann, J. J., & Parsey, R. V. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.002 · Cited by 97 · see citing works
Peng, H., Wu, K., Li, J., Qi, H., Guo, S., Chi, M., Wu, X.-M., Guo, Y., Yang, Y., & Ning, Y. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.046 · Cited by 89 · see citing works
Lee, Y. J., Kim, S., Gwak, A. R., Kim, S. J., Kang, S., Na, K., Son, Y., & Park, J. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.02.013 · Cited by 84 · see citing works
Zhang, H., Chen, Z., Jia, Z., & Gong, Q. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.002 · Cited by 72 · see citing works
Self-citationMagnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder
Chen, Z., Zhang, H., Jia, Z., Zhong, J., Huang, X., Du, M., Chen, L., Kuang, W., Sweeney, J. A., & Gong, Q. (2015) · Scientific Reports · doi:10.1038/srep09670 · Cited by 41 · see citing works
Self-citationMinzenberg, M. J., Lesh, T. A., Niendam, T. A., Cheng, Y., & Carter, C. S. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15120422 · Cited by 28 · see citing works
Clinical impact of a 2-week psychotropic medication washout in unipolar depressed inpatients
Grunebaum, M. F., Oquendo, M. A., Burke, A. K., Ellis, S. P., Echavarria, G., Brodsky, B. S., Malone, K. M., & Mann, J. J. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00168-4 · Cited by 25 · see citing works
Marchand, W. R. (2011) · Depression Research and Treatment · doi:10.1155/2012/246725 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sun, X., Sun, J., Lu, X., Dong, Q., Zhang, L., Wang, W., Liu, J., Ma, Q., Wang, X., Wei, D., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.05.021 · Cited by 129 · see citing works
Self-citationНиколаевна, П. Е., Maximenko, V. A., Kurkin, S., Sergeev, A., Stoyanov, D., Paunova, R., Kandilarova, S., Simeonova, D., & Hramov, A. E. (2023) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2022.113041 · Cited by 105 · see citing works
Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode
Stoyanov, D., Khorev, V. S., Paunova, R., Kandilarova, S., Simeonova, D., Badarin, A., Kurkin, S., & Hramov, A. E. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114045 · Cited by 62 · see citing works
Yang, Z., Jian, L., Qiu, H., Zhang, C., Cheng, S., Ji, J., Li, T., Wang, Y., Li, J., & Li, K. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01646-7 · Cited by 57 · see citing works
McAvoy, M. B., Calvachi, P., Kaczmarzyk, J., Fernández, I. S., McNulty, J. J., Smith, T. R., Yu, K., Gormley, W. B., & Arnaout, O. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-94733-0 · Cited by 47 · see citing works
Xu, M., Zhang, X., Li, Y., Chen, S., Zhang, Y., Zhou, Z., Lin, S., Dong, T., Hou, G., & Qiu, Y. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02147-x · Cited by 46 · see citing works
Aberrant brain dynamics in major depressive disorder with suicidal ideation
Yang, J., Liu, Z., Tao, H., Cheng, Y., Fan, Z., Sun, F., Ouyang, X., & Yang, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.07.043 · Cited by 34 · see citing works
Vieira, R., Faria, A. R., Ribeiro, D., Picó‐Pérez, M., & Bessa, J. M. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110799 · Cited by 34 · see citing works
Wáng, Q., He, C., Wang, Z., Fan, D., Zhang, Z., Xie, C., Yan, C., Chen, X., Li, L., Castellanos, F. X., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02655-4 · Cited by 26 · see citing works
Self-citationXie, H., Cao, Y., Li, J., Lyu, Y., Roberts, N., & Jia, Z. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.082 · Cited by 26 · see citing works
Self-citationGroup independent components underpin responses to items from a depression scale
Stoyanov, D., Khorev, V. S., Paunova, R., Kandilarova, S., Kurkin, S., & Calhoun, V. D. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.22 · Cited by 13 · see citing works
Wen, X., Zhang, J.-H., Wei, G., Wu, M.-L., Zhang, Y., Zhang, Q., & Hou, G.-Q. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.10.009 · Cited by 10 · see citing works
Chi, S., Mok, Y. E., Lee, J., Suh, S., Han, C., & Lee, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.09.027 · Cited by 10 · see citing works
Disrupted olfactory functional connectivity in patients with late-life depression
Yang, M., Chen, B., Zhong, X., Zhou, H., Mai, N., Zhang, M., Wu, Z., Peng, Q., Wang, Q., Liu, M., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.014 · Cited by 10 · see citing works
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Shen, Y., Zhu, J., & Yu, Y. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.10.035 · Cited by 7 · see citing works
Diao, Y., Huang, Y., Guo, M., Li, W., Wang, W., Li, Z., Zhang, H., Zhou, J., Li, X., Wu, F., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03965-z · Cited by 7 · see citing works
Xiao, X., Sun, J., Tian, J., Sun, X., Yang, C., Ying, H., Zhao, Y., Yu, X., Li, M., Li, S., et al. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111906 · Cited by 6 · see citing works
Self-citationZhang, J., Zhou, N., Song, K., Zou, B.-W., Xu, L., Fu, Y., Geng, X., Wang, Z., Li, X., Potenza, M. N., et al. (2022) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2022.101186 · Cited by 6 · see citing works
Association of resting-state EEG with suicidality in depressed patients: a systematic review
Shamsi, F., Azadinia, F., & Vafaee, F. (2025) · BMC Psychiatry · doi:10.1186/s12888-024-06464-x · Cited by 5 · see citing works
Meda, N., Miola, A., Cattarinussi, G., & Sambataro, F. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.10.003 · Cited by 6 · see citing works
Jing, Y., Zhang, M., Liu, Y., Gao, Y., Zhang, B., Chen, C., Xuekelaiti, Z., Zhou, Y., Zhang, C., Li, M., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07483-y · Cited by 4 · see citing works
Tian, M., Lin, L., Liu, Y., Qiu, S., Yang, Y., & Xu, Z. (2024) · Current Psychology · doi:10.1007/s12144-024-06574-5 · Cited by 6 · see citing works
Chen, G., Sun, X., Chen, P., Bu, X., Qi, Z., Zhang, S., Chen, C., Guo, Z., Tang, X., Chen, R., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03457-y · Cited by 2 · see citing works
Self-citationChen, S., Zhang, X., Lin, S., Zhang, Y., Xu, Z., Li, Y., Xu, M., Hou, G., & Qiu, Y. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00826-x · Cited by 1 · see citing works
Fattahi, M., Esmaeil-Zadeh, M., Hamid Soltanian-zadeh, A., Rostami, R., Mansouri, J., & Hossein‐Zadeh, G. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1427532 · Cited by 1 · see citing works
Jing, W., Yang, L., Guo, Y., Chen, D., Che, K., Dong, F., Li, C., Shi, Y., Xie, H., Zhao, F., et al. (2025) · Academic Radiology · doi:10.1016/j.acra.2025.07.047 · Cited by 1 · see citing works
Zhang, X., Wang, R., Chen, Y., Fang, S., Wu, Y., Lin, P., & Wang, X. (2025) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-025-02052-6 · Cited by 1 · see citing works
Cheng, S.-C., Wang, Y.-M., Li, Y., Yao, Q.-N., Huang, X.-L., Ji, J., Zhang, X.-B., & Sun, H.-Y. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i1.113230 · Cited by 1 · see citing works
Luo, Q. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27834
Othman, E. A. (2022) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28536
Sun, Y., Mao, X., & Hou, P. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149522
Kim, W.-S., Odkhuu, S., Setiani, A., Li, L., So, J.-Y., Nazir, S., & Chung, Y. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.112117
Li, T., Wang, Y., Li, F., Chen, X., Lu, B., Wang, Y., Li, X., Wang, Z., Li, H., Liao, Y., et al. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121200
Self-citationWei, H., Li, H., Hao, Z., Chen, Y., Chen, J., & Fu, Y. (2026) · Brain Imaging and Behavior · doi:10.1007/s11682-026-01126-w
Zhang, Q., Bao, C., Chen, W., Hua, L., Yan, R., Zou, H., Yao, Z., & Lu, Q. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.04.036
Qin, K., Ran, J., Pan, N., Shao, Y., Roberts, N., & Jia, Z. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.08.007
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- Authors
- Chen, Z., Xia, M., Zhao, Y., Kuang, W., Jia, Z., & Gong, Q.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Normal University (CN)
- Sichuan University (CN)
- Corresponding author
- Jia, Zhiyun
- Gong, Qiyong
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2021-06-16
- Volume
- 54
- Issue
- 6
- Pages
- 1867-1875
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W3170117414
- Cited by
- 38
- References
- 39
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 3
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81621003, 81971595, 81801681, 81671767, 81820108018)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, suicide attempts, seed-based functional connectivity, orbitofrontal cortex, dorsomedial prefrontal cortex, hippocampus, resting-state networks, suicide risk, brain circuits
- MeSH terms
- Brain, Brain Mapping, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Prospective Studies, Suicidal Ideation
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