Cited by 110Functional Brain Connectivity StudiesSuicide and Self-Harm StudiesTreatment of Major Depression

Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder

Kang, Seung-Gul, Na, Kyoung-Sae, Choi, Jae-Won, Kim, Jeong-Hee, Son, Young-Don, Lee, Yu Jin·2017·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2017.04.029

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Suicidal ideation relates to greater rs-fMRI activity in the vmPFC and greater resting functional connectivity between the OFC and amygdala and between the posterior cingulate cortex and middle temporal gyrus.

    “Suicidal ideation relates to greater rs-fMRI activity in the vmPFC (88) and greater resting functional connectivity between the OFC and amygdala (89) and between the posterior cingulate cortex and middle temporal gyrus (90), perhaps related to negative self-reflection or rumination (91).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [89]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kang, S.-G., Na, K.-S., Choi, J.-W., Kim, J.-H., Son, Y.-D., & Lee, Y. J.
Affiliations
  • Gachon University (KR)
  • Eulji University (KR)
  • Korea University (KR)
  • Seoul National University (KR)
Corresponding author
  • Son, Young-Don
  • Lee, Yu Jin
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2017-07
Volume
77
Pages
222-227
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2605816761
Cited by
110
References
48
Citations by year
2026: 7 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 1
FWCI
6.91
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Science and Technology
  • National Research Foundation of Korea (2012R1A1A1043599)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
resting-state functional connectivity, amygdala, suicide attempters, major depressive disorder, suicidal ideation, insula, middle temporal cortex, parahippocampal cortex, depression pathophysiology
MeSH terms
Amygdala, Brain, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Neural Pathways, Rest, Suicide, Attempted, Case-Control Studies, Functional Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review