Resting-state functional connectivity of the amygdala in suicide attempters with major depressive disorder
Abstract
In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.
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Suicidal ideation relates to greater rs-fMRI activity in the vmPFC and greater resting functional connectivity between the OFC and amygdala and between the posterior cingulate cortex and middle temporal gyrus.
“Suicidal ideation relates to greater rs-fMRI activity in the vmPFC (88) and greater resting functional connectivity between the OFC and amygdala (89) and between the posterior cingulate cortex and middle temporal gyrus (90), perhaps related to negative self-reflection or rumination (91).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [89]
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- Authors
- Kang, S.-G., Na, K.-S., Choi, J.-W., Kim, J.-H., Son, Y.-D., & Lee, Y. J.
- Affiliations
- Gachon University (KR)
- Eulji University (KR)
- Korea University (KR)
- Seoul National University (KR)
- Corresponding author
- Son, Young-Don
- Lee, Yu Jin
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 77
- Pages
- 222-227
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2605816761
- Cited by
- 110
- References
- 48
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 1
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology
- National Research Foundation of Korea (2012R1A1A1043599)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- resting-state functional connectivity, amygdala, suicide attempters, major depressive disorder, suicidal ideation, insula, middle temporal cortex, parahippocampal cortex, depression pathophysiology
- MeSH terms
- Amygdala, Brain, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Neural Pathways, Rest, Suicide, Attempted, Case-Control Studies, Functional Neuroimaging
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