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Cited by 31Diabetes Treatment and ManagementDiabetes Management and ResearchNatural Antidiabetic Agents Studies

Novel therapeutic agents for management of diabetes mellitus: A hope for drug designing against diabetes mellitus

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Elkhalifa, Ahmed M. E., Nazar, Mehak, Ali, Sofi Imtiyaz, Khursheed, Ibraq, Taifa, Syed, Ahmad Mir, Muzafar, Shah, Iqra Hussain, Malik, Masood +12 more·2024·Life
DOI 10.3390/life14010099PMC PMC10821096
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Abstract

Diabetes mellitus (DM) is characterized by an absolute decline in insulin secretion and peripheral resistance and is the most prevalent metabolic and endocrine disorder. However, the pathogenesis of DM also includes adipocyte insulin resistance, increased glucagon secretion, increased renal glomerular glucose absorption, and neurotransmitter dysfunction. Although there is a wide spectrum of therapeutics available for glycemic control, owing to the identification of various pathogenic determinants of DM, management of DM remains challenging and complex. Current therapeutic interventions against DM focus mostly on glycemic control without considering the other pathological determinants that eventually lead to treatment failure and the progression of DM. Furthermore, long-term use of these conventionally available anti-diabetic drugs leads to various side effects, henceforth development of novel drugs against DM remains an unending search strategy for researchers. Various studies conducted in various parts of the world have proposed that these novel therapeutic interventions target multiple and alternate pathogenic hotspots involved in DM. The current review article discusses novel therapeutic options that hold particular promise to support their safety and discuss the side effects resulting from their use so that these novel candidate drugs can be effectively fabricated into potential drugs for the treatment of DM.

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  • Early pharmacologic therapy in type 2 diabetes mellitus is linked to improving glucose control and lowering long-term consequences.

    “Improving glucose control and lowering long-term consequences in T2DM are linked to early pharmacologic therapy beginning.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [52]

    The Introduction (section 1; page unavailable) describes drugs used to manage hyperglycemia, and the Conclusions (section 4; page unavailable) say newer drugs help maintain blood glucose within the desired range. Neither passage links early initiation of pharmacologic therapy in T2DM to improved control or fewer long-term consequences. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Elkhalifa, A. M. E., Nazar, M., Ali, S. I., Khursheed, I., Taifa, S., Ahmad Mir, M., Shah, I. H., Malik, M., Ramzan, Z., Ahad, S., Bashir, N., Elamin, E., Bazie, E. A., Ahmed, E. M., Alruwaili, M. M., Baltoyour, A. W., Alarfaj, A. S., Ali Al Bataj, I., Arabe, A. M. A., & Nabi, S. U.
Affiliations
  • Saudi Electronic University (SA)
  • Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (IN)
  • Department of Zoology, Central University of Kashmir, Nunar, Ganderbal 191201, India
  • Preclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar 190006, India
  • University of El Imam El Mahdi (SD)
  • Jouf University (SA)
  • Ministry of Health (SA)
  • Dr. Suliman Al-Habib Hospital, Riyadh 11372, Saudi Arabia
  • Najran General Hospital, Ministry of Health, Najran 66277, Saudi Arabia
Corresponding author
Nabi, Showkat Ul
ORCID
Venue
Life
Publisher
MDPI AG
Published
2024-01-08
Volume
14
Issue
1
Pages
99
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life14010099
PMC
PMC10821096
OpenAlex
W4390745176
Cited by
31
References
6
Citations by year
2026: 4 · 2025: 20 · 2024: 7
FWCI
1.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Department of Public Health, College of Health Sciences, Saudi Electronic University Public Health Saudi Arabia
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
diabetes mellitus, novel therapeutic agents, insulin resistance, insulin secretion, glucagon secretion, renal glucose reabsorption, neurotransmitter dysfunction, glycemic control, adverse drug reactions

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