The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Microgravity-Induced Fluid Shift and Ophthalmic Changes
Open accessAbstract
Although changes to visual acuity in spaceflight have been observed in some astronauts since the early days of the space program, the impact to the crew was considered minor. Since that time, missions to the International Space Station have extended the typical duration of time spent in microgravity from a few days or weeks to many months. This has been accompanied by the emergence of a variety of ophthalmic pathologies in a significant proportion of long-duration crewmembers, including globe flattening, choroidal folding, optic disc edema, and optic nerve kinking, among others. The clinical findings of affected astronauts are reminiscent of terrestrial pathologies such as idiopathic intracranial hypertension that are characterized by high intracranial pressure. As a result, NASA has placed an emphasis on determining the relevant factors and their interactions that are responsible for detrimental ophthalmic response to space. This article will describe the Visual Impairment and Intracranial Pressure syndrome, link it to key factors in physiological adaptation to the microgravity environment, particularly a cephalad shifting of bodily fluids, and discuss the implications for ocular biomechanics and physiological function in long-duration spaceflight.
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Cited by
Human Pathophysiological Adaptations to the Space Environment
Demontis, G. C., Germani, M. M., Caiani, E. G., Barravecchia, I., Passino, C., & Angeloni, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00547 · Cited by 354
Effect of gravity and microgravity on intracranial pressure
Lawley, J. S., Petersen, L. G., Howden, E. J., Sarma, S., Cornwell, W. K., Zhang, R., Whitworth, L. A., Williams, M. A., & Levine, B. D. (2017) · The Journal of Physiology · doi:10.1113/jp273557 · Cited by 312
Brain ventricular volume changes induced by long-duration spaceflight
Van Ombergen, A., Jillings, S., Jeurissen, B., Tomilovskaya, E., Rumshiskaya, A., Litvinova, L., Nosikova, I., Pechenkova, E., Rukavishnikov, I., Manko, O., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820354116 · Cited by 148
Lee, J. K., Koppelmans, V., Riascos, R. F., Hasan, K. M., Pasternak, O., Mulavara, A. P., Bloomberg, J. J., & Seidler, R. D. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.4882 · Cited by 149
Metadata
- Authors
- Nelson, E., Mulugeta, L., & Myers, J.
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2014-11-07
- Volume
- 4
- Issue
- 4
- Pages
- 621-665
- ISSN
- 2075-1729 (ISSN-L)
- OpenAlex
- W2026424365
- Cited by
- 167
- References
- 10
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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