Investigating Prebiotic Protocells for a Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective
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Protocells are supramolecular systems commonly used for numerous applications, such as the formation of self-evolvable systems, in systems chemistry and synthetic biology. Certain types of protocells imitate plausible prebiotic compartments, such as giant vesicles, that are formed with the hydration of thin films of amphiphiles. These constructs can be studied to address the emergence of life from a non-living chemical network. They are useful tools since they offer the possibility to understand the mechanisms underlying any living cellular system: Its formation, its metabolism, its replication and its evolution. Protocells allow the investigation of the synergies occurring in a web of chemical compounds. This cooperation can explain the transition between chemical (inanimate) and biological systems (living) due to the discoveries of emerging properties. The aim of this review is to provide an overview of relevant concept in prebiotic protocell research.
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Spontaneous homochiral symmetry breaking happened in a heterogeneous rather than a homogeneous environment such as space interstellar clouds, deep sea smokers or hydrothermal pools, where organic and inorganic compounds could have interacted due to external forces like radiation, heat or both.
“To our understanding, spontaneous homochiral symmetry breaking happened in a heterogeneous rather than a homogeneous environment such as space interstellar clouds, deep sea smokers or hydrothermal pools, where organic (carbon-based compounds) and inorganic (essentially minerals) compounds could have interacted due to external forces like radiation, heat or both.”
From The Origin and Early Evolution of Life: Homochirality Emergence in Prebiotic Environments (2023) · cites this paper as Lopez and Fiore, 2019
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- Authors
- Lopez, A., & Fiore, M.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Fiore, Michele
- ORCID
- Fiore, Michele
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2019-06-07
- Volume
- 9
- Issue
- 2
- Pages
- 49
- ISSN
- 2075-1729 (ISSN-L)
- PMC
- PMC6616946
- OpenAlex
- W2948675573
- Cited by
- 89
- References
- 124
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 23 · 2021: 16 · 2020: 11 · 2019: 3 · 2018: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Life (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- origin of life, giant vesicles, self-evolving systems, synthetic biology, supramolecular systems, chemical reaction networks, lipid vesicles
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