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Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases
Open accessAbstract
Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.
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“Since polyunsaturated fatty acids (Figure 5) show biological properties, like cardiovascular protection, antiproliferative, and anti-inflammatory activity, their presence in macroalgae makes them very important for human health [6].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [6]
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“Due to the presence of biocompounds in macroalgae, they possess a wide range of bioactivities, such as anti-aging, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, antidiabetic, and neuroprotective activity [5,6,7].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [6]
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Metadata
- Authors
- Barbosa, M., Valentão, P., & Andrade, P.
- Affiliations
- Universidade do Porto (PT)
- REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
- Corresponding author
- Andrade, Paula
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2014-09-25
- Volume
- 12
- Issue
- 9
- Pages
- 4934-4972
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4178484
- OpenAlex
- W1975237170
- Cited by
- 181
- References
- 177
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 23 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 21 · 2019: 19 · 2018: 23 · 2017: 6 · 2016: 11 · 2015: 4 · 2014: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission (Pest-C/EQB/LA0006/2013)
- Fundação para a Ciência e a Tecnologia (COMPETE, C/EQB/LA0006/2013, PEst-C/EQB/LA0006/2013, SFRH/BD/95861/2013)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- seaweed, bioactive compounds, neuroprotection, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, marine natural products, nutraceuticals, pharmaceuticals, dementia
- MeSH terms
- Animals, Antioxidants, Humans, Seaweed, Water Microbiology, Neuroprotective Agents, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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