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Cited by 248Marine Sponges and Natural ProductsSeaweed-derived Bioactive CompoundsAnalytical chemistry methods development

The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

Open access
Grosso, Clara, Valentão, Patrícia, Ferreres, Federico, Andrade, Paula·2015·Marine Drugs
DOI 10.3390/md13053182PMC PMC4446625
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Abstract

Marine ecosystems cover more than 70% of the globe's surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered.

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Research works printed but not linked: 2

  1. Hickey, A.J., and Ganderton, D. (2009). Pharmaceutical Process Engineering, CRC Press; Taylor and Francis Group. [2nd ed.].
  2. Rocha-Santos, T., and Duarte, A.C. (2014). Analysis of Marine Samples in Search of Bioactive Compounds, Elsevier.

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Metadata

Authors
Grosso, C., Valentão, P., Ferreres, F., & Andrade, P.
Affiliations
  • Universidade do Porto (PT)
  • REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal
  • Centro de Edafología y Biología Aplicada del Segura (ES)
Corresponding author
Andrade, Paula
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2015-05-21
Volume
13
Issue
5
Pages
3182-3230
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md13053182
PMC
PMC4446625
OpenAlex
W1506732456
Cited by
248
References
211
Citations by year
2026: 17 · 2025: 38 · 2024: 29 · 2023: 18 · 2022: 27 · 2021: 29 · 2020: 26 · 2019: 15 · 2018: 17 · 2017: 23 · 2016: 8 · 2015: 1
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Strong
  • European Commission (Pest-C/EQB/LA0006/2013, NORTE-07-0124 FEDER-000069)
  • CYTED Ciencia y Tecnología para el Desarrollo (112RT0460)
  • Fundação para a Ciência e a Tecnologia (COMPETE, NORTE-07-0124-FEDER-000069, PEst-C/EQB/LA0006/2013, IF/01332/2014)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
Keywords
marine natural products, extraction methods, supercritical fluid extraction, accelerated solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, enzymatic extraction, switchable solvents, ionic liquids, marine metabolites, bioactive compounds
MeSH terms
Animals, Biological Products, Humans, Marine Biology, Microwaves, Solvents, Chromatography, Supercritical Fluid, Aquatic Organisms

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