Cited by 248Marine Sponges and Natural ProductsSeaweed-derived Bioactive CompoundsAnalytical chemistry methods development

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Alternative and Efficient Extraction Methods for Marine-Derived Compounds

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Grosso, Clara, Valentão, Patrícia, Ferreres, Federico, Andrade, Paula·2015·Marine Drugs

DOI 10.3390/md13053182PMC PMC4446625

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Abstract

Marine ecosystems cover more than 70% of the globe's surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered.

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Authors: Grosso, C., Valentão, P., Ferreres, F., & Andrade, P.
Affiliations: Universidade do Porto (PT)
REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal
Centro de Edafología y Biología Aplicada del Segura (ES)
Corresponding author: Andrade, Paula
ORCID: Grosso, Clara
Valentão, Patrícia
Ferreres, Federico
Andrade, Paula
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2015-05-21
Volume: 13
Issue: 5
Pages: 3182-3230
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md13053182
PMC: PMC4446625
OpenAlex: W1506732456
Cited by: 248
References: 211
Citations by year: 2026: 17 · 2025: 38 · 2024: 29 · 2023: 18 · 2022: 27 · 2021: 29 · 2020: 26 · 2019: 15 · 2018: 17 · 2017: 23 · 2016: 8 · 2015: 1
FWCI: 1.87
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Strong
European Commission (Pest-C/EQB/LA0006/2013, NORTE-07-0124 FEDER-000069)
CYTED Ciencia y Tecnología para el Desarrollo (112RT0460)
Fundação para a Ciência e a Tecnologia (COMPETE, NORTE-07-0124-FEDER-000069, PEst-C/EQB/LA0006/2013, IF/01332/2014)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
Keywords: marine natural products, extraction methods, supercritical fluid extraction, accelerated solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, enzymatic extraction, switchable solvents, ionic liquids, marine metabolites, bioactive compounds
MeSH terms: Animals, Biological Products, Humans, Marine Biology, Microwaves, Solvents, Chromatography, Supercritical Fluid, Aquatic Organisms

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Alternative and Efficient Extraction Methods for Marine-Derived Compounds

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