Cited by 395Algal biology and biofuel productionLipid metabolism and biosynthesisMicrobial Metabolic Engineering and Bioproduction

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Lipid Production from Nannochloropsis

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Ma, Xiao-Nian, Chen, Tian-Peng, Yang, Bo, Liu, Jin, Chen, Feng·2016·Marine Drugs

DOI 10.3390/md14040061PMC PMC4849066

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Abstract

Microalgae are sunlight-driven green cell factories for the production of potential bioactive products and biofuels. Nannochloropsis represents a genus of marine microalgae with high photosynthetic efficiency and can convert carbon dioxide to storage lipids mainly in the form of triacylglycerols and to the ω-3 long-chain polyunsaturated fatty acid eicosapentaenoic acid (EPA). Recently, Nannochloropsis has received ever-increasing interests of both research and public communities. This review aims to provide an overview of biology and biotechnological potential of Nannochloropsis, with the emphasis on lipid production. The path forward for the further exploration of Nannochloropsis for lipid production with respect to both challenges and opportunities is also discussed.

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Figure 1 Micrographs of typical N. oculata representing (a) the morphology; and (b) different organelles. LD, lipid droplet; N, nucleus; ST, stacks of thylakoids; V, vacuoles. Bars = 2 μm for (a) and 0.5 μm for (b).CC BY · PubMed Central

Figure 2 Schematic diagrams of the replication cycle of N. oculata. The order of the nuclear (N) and plastid (P) division is not strictly fixed. Nuclear division precedes the plastid division (upper); or vice versa (lower) [18].CC BY · PubMed Central

Figure 3 Publications on Nannochloropsis in the past 20 years (1995–2014) (from Web of knowledge).CC BY · PubMed Central

Figure 4 The lipid biosynthesis pathway in Nannochloropsis. (a) The carbon metabolic pathways related to lipid synthesis; (b) The proposed PUFA biosynthesis pathway. PDHC, pyruvate dehydrogenase complex; ACCase, acetyl-CoA carboxylase; FAS, fatty acid synthase; ME, malic enzyme; LPAT, lysophosphatidate acyltransferase; PAP, phosphatidic acid phosphatase; DGAT, diacylglycerol acyltransferase; PUFA, polyunsaturated fatty acid; TCA cycle, tricarboxylic acid cycle; PPP, pentose phosphate pathway.CC BY · PubMed Central

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Authors: Ma, X.-N., Chen, T.-P., Yang, B., Liu, J., & Chen, F.
Affiliations: Institute for Food and Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China
Peking University (CN)
Corresponding author: Liu, Jin
Chen, Feng
ORCID: Ma, Xiao-Nian
Yang, Bo
Liu, Jin
Chen, Feng
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2016-03-25
Volume: 14
Issue: 4
Pages: 61
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md14040061
PMC: PMC4849066
OpenAlex: W2309000102
Cited by: 394
References: 104
Citations by year: 2026: 48 · 2025: 52 · 2024: 37 · 2023: 44 · 2022: 33 · 2021: 43 · 2020: 46 · 2019: 38 · 2018: 31 · 2017: 17 · 2016: 3
FWCI: 1.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31471717, 31571807)
Peking University
Ocean Public Welfare Scientific Research Project (201505032)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: Nannochloropsis, microalgae, lipid production, triglycerides, eicosapentaenoic acid, omega-3 fatty acids, biofuels, photosynthetic efficiency, CO2 conversion, microalgal biotechnology
MeSH terms: Animals, Biotechnology, Humans, Lipids, Triglycerides, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Stramenopiles, Microalgae

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