Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus
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Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.
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After treatment with extracts, cells express apoptotic markers such as fragmentation of nucleus, shrinkage of cells, and release of apoptotic substances.
“After treatment with extracts, cells express apoptotic markers, such as fragmentation of nucleus, shrinkage of cells, and release of apoptotic substances [240].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [240]
Extracts of Synechocystis sp. and Synechococcus sp. drive HL-60 cells into apoptotic conditions.
“Extracts of Synechocystis sp. and Synechococcus sp. have been shown to drive HL-60 cells into apoptotic conditions.”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [240]
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Cites
Antibiotic Susceptibility Testing by a Standardized Single Disk Method
Bauer, A. W., Kirby, W. M. M., Sherris, J. C., & Turck, M. (1966) · American Journal of Clinical Pathology · doi:10.1093/ajcp/45.4_ts.493 · Cited by 18,523 · see citing works
Exocellular polysaccharides from cyanobacteria and their possible applications
Philippis, R. D., & Vincenzini, M. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00365.x · Cited by 661 · see citing works
Natural products in anticancer therapy
Ab, D. R. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00063-7 · Cited by 606 · see citing works
Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00085a006 · Cited by 365 · see citing works
Anti-HIV Activity of Extracts and Compounds from Algae and Cyanobacteria
Schaeffer, D. J., & Krylov, V. S. (2000) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1999.1862 · Cited by 326 · see citing works
Suikkanen, S., Fistarol, G. O., & Granéli, E. (2004) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2004.02.012 · Cited by 226 · see citing works
Deoxycylindrospermopsin, an analog of cylindrospermopsin fromCylindrospermopsis raciborskii
Norris, R. L. G., Eaglesham, G. K., Pierens, G., Shaw, G. R., Smith, M. J., Chiswell, R. K., Seawright, A. A., & Moore, M. R. (1999) · Environmental Toxicology · doi:10.1002/(sici)1522-7278(199902)14:1 · Cited by 188 · see citing works
Marine pharmacology in 2000: Antitumor and cytotoxic compounds
Mayer, A. M. S., & Gustafson, K. R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11080 · Cited by 168 · see citing works
The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
McDermott, C. M., Nho, C. W., Howard, W., & Holton, B. (1998) · Toxicon · doi:10.1016/s0041-0101(98)00128-7 · Cited by 164 · see citing works
Shimizu, Y. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00064-x · Cited by 157 · see citing works
Microalgae as a source of bioactive molecules – experience from cyanophyte research
Skulberg, O. M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008140403621 · Cited by 144 · see citing works
Ostensvik, Skulberg, Underdal, & Hormazabal (1998) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1998.00449.x · Cited by 134 · see citing works
Biochemical and pharmacological investigations of selected cyanobacteria
Mundt, S., Kreitlow, S., Nowotny, A., & Effmert, U. (2001) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00045 · Cited by 132 · see citing works
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes
Fladmark, K. E., Serres, M. H., Larsen, N. L., Yasumoto, T., Aune, T., & Døskeland, S. O. (1998) · Toxicon · doi:10.1016/s0041-0101(98)00083-x · Cited by 128 · see citing works
Evaluation ofNostocStrain ATCC 53789 as a Potential Source of Natural Pesticides
Biondi, N., Piccardi, R., Margheri, M. C., Rodolfi, L., Smith, G. D., & Tredici, M. R. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3313-3320.2004 · Cited by 122 · see citing works
Schlegel, I., Doan, N. T., de Chazal, N. M., & Smith, G. D. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008042619686 · Cited by 112 · see citing works
Cyanobacteria—a potential source of new biologically active substances
Kreitlow, S., Mundt, S., & Lindequist, U. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00058-9 · Cited by 109 · see citing works
The dolastatins, a family of promising antineoplastic agents
Poncet, J. (1999) · Current Pharmaceutical Design · doi:10.2174/1381612805666230109214008 · Cited by 104 · see citing works
Biodiversity and potentials of marine-derived microorganisms
Sponga, F., Cavaletti, L., Lazzarini, A., Borghi, A., Ciciliato, I., Losi, D., & Marinelli, F. (1999) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00059-0 · Cited by 103 · see citing works
Antibiotic production by the cyanobacteria Oscillatoria angustissima and Calothrix parietina
Issa, A. A. (1999) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(99)00027-7 · Cited by 80 · see citing works
Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes
Mankiewicz‐Boczek, J., Tarczyńska, M., Fladmark, K. E., Døskeland, S. O., Walter, Z., & Zalewski, M. (2001) · Environmental Toxicology · doi:10.1002/tox.1028 · Cited by 54 · see citing works
Toxicological analysis of the marine cyanobacterium Nodularia harveyana
Pushparaj, B., Pelosi, E., & Jüttner, F. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008080615337 · Cited by 48 · see citing works
DIXON, R. A., Al-Nazawi, M., & Alderson, G. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00910-8 · Cited by 38 · see citing works
Mellgren, G., Vintermyr, O. K., & Døskeland, S. O. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041630203 · Cited by 38 · see citing works
Antimicrobial activity of cyanobacteria
Rao, C. S. (1994) · Indian Journal of Marine Sciences · Cited by 25 · see citing works
Bironaitė, D., Siegel, D. M., Moran, J. L., Weksler, B. B., & Ross, D. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.06.004 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [28]28. Moore, R.E.; Patterson, G.M.L.; Carmichael, W.W. New pharmaceuticals from cultured blue-green algae. In Biomedical importance of marine organisms; Fautin, D.G., Ed.; Mem. Cal. Acad. Sci., 1988; Volume 13, pp. 143-150.
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
Biotechnological and industrial significance of cyanobacterial secondary metabolites.
Rastogi, R. P., & Sinha, R. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.04.009 · Cited by 349 · see citing works
Mini-review: Inhibition of biofouling by marine microorganisms
Dobretsov, S., Abed, R. M. M., & Teplitski, M. (2013) · Biofouling · doi:10.1080/08927014.2013.776042 · Cited by 283 · see citing works
Mayer, A. M. S., Rodrı́guez, A. D., Berlinck, R. G. S., & Fusetani, N. (2010) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2010.08.008 · Cited by 270 · see citing works
Kumar, B. R., Mathimani, T., Sudhakar, M. P., Rajendran, K., Nizami, A.-S., Brindhadevi, K., & Pugazhendhi, A. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2020.110649 · Cited by 208 · see citing works
Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology
Barzkar, N., Jahromi, S. T., Poorsaheli, H. B., & Vianello, F. (2019) · Marine Drugs · doi:10.3390/md17080464 · Cited by 177 · see citing works
Marine cyanobacteria compounds with anticancer properties: A review on the implication of apoptosis
Costa, M., Costa-Rodrigues, J., Fernandes, M. H., Barros, P., Vasconcelos, V., & Martins, R. (2012) · Marine Drugs · doi:10.3390/md10102181 · Cited by 147 · see citing works
Self-citationRajneesh, Singh, S. P., Pathak, J., & Sinha, R. P. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2016.11.110 · Cited by 120 · see citing works
Wright, R. M., Kenkel, C. D., Dunn, C. E., Shilling, E. N., Bay, L. K., & Matz, M. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-02685-1 · Cited by 108 · see citing works
Wang, L., Zi, J., Xu, R., Hilt, S., Hou, X., & Chang, X. (2016) · Harmful Algae · doi:10.1016/j.hal.2016.11.010 · Cited by 102 · see citing works
Bouyahya, A., Bakrim, S., Chamkhi, I., Taha, D., Omari, N. E., Mneyiy, N. E., Hachlafi, N. E., El‐Shazly, M., Khalid, A., Abdalla, A. N., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115989 · Cited by 96 · see citing works
Diversity, Ecology, and Prevalence of Antimicrobials in Nature
Mullis, M. M., Rambo, I. M., Baker, B. J., & Reese, B. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02518 · Cited by 87 · see citing works
Frazão, B., Martins, R. F., & Vasconcelos, V. M. (2010) · Marine Drugs · doi:10.3390/md8061908 · Cited by 80 · see citing works
Self-citationAnticancer, Antiviral, Antibacterial, and Antifungal Properties in Microalgae
Dewi, I. C., Falaise, C., Hellio, C., Bourgougnon, N., & Mouget, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811405-6.00012-8 · Cited by 80 · see citing works
Costa, M., Garcia, M. P., Costa‐Rodrigues, J., Costa, M., Ribeiro, M., Fernandes, M. H., Barros, P., Barreiro, A., Vasconcelos, V. M., & Martins, R. F. (2013) · Marine Drugs · doi:10.3390/md12010098 · Cited by 77 · see citing works
Self-citationAnti-infective Natural Products from Cyanobacteria
Niedermeyer, T. H. J. (2015) · Planta Medica · doi:10.1055/s-0035-1546055 · Cited by 70 · see citing works
Allelopathic and Bloom-Forming Picocyanobacteria in a Changing World
Śliwińska‐Wilczewska, S., Maculewicz, J., Barreiro, A., & Latała, A. (2018) · Toxins · doi:10.3390/toxins10010048 · Cited by 69 · see citing works
Nainangu, P., Antonyraj, A. P. M., Subramanian, K., Kaliyaperumal, S., Suresh, G., Renuga, P. S., & Wilson Aruni, A. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101772 · Cited by 66 · see citing works
Alghazeer, R. O., Whida, F., Abduelrhman, E., Gammoudi, F., & Azwai, S. M. (2013) · Natural Science · doi:10.4236/ns.2013.51002 · Cited by 66 · see citing works
Baltic cyanobacteria – a source of biologically active compounds
Mazur‐Marzec, H., Błaszczyk, A., Felczykowska, A., Hohlfeld, N., Kobos, J., Toruńska-Sitarz, A., Devi, P., Montalvão, S. I. G. H. M., D’Souza, L., Tammela, P., et al. (2015) · European Journal of Phycology · doi:10.1080/09670262.2015.1062563 · Cited by 64 · see citing works
Oftedal, L., Selheim, F., Wahlsten, M., Sivonen, K., Døskeland, S. O., & Herfindal, L. (2010) · Marine Drugs · doi:10.3390/md8102659 · Cited by 62 · see citing works
Self-citationSurendhiran, D., Li, C., Cui, H., & Lin, L. (2021) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2021.109416 · Cited by 59 · see citing works
Paz-Yepes, J., Brahamsha, B., & Palenik, B. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306260110 · Cited by 58 · see citing works
Tripathi, V. C., Satish, S., Horam, S., Raj, S., lal, A., Arockiaraj, J., Pasupuleti, M., & Dikshit, D. K. (2018) · Polar Science · doi:10.1016/j.polar.2018.04.006 · Cited by 54 · see citing works
Śliwińska‐Wilczewska, S., Wiśniewska, K. A., Konarzewska, Z., Cieszyńska, A., Barreiro, A., Lewandowska, A. U., & Latała, A. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145681 · Cited by 54 · see citing works
Antitumor activity of C-phycocyanin from Arthronema africanum (Cyanophyceae)
Gardeva, E. G., Toshkova, R. A., Yossifova, L., Minkova, K., Ivanova, N., & Gigova, L. G. (2014) · Brazilian Archives of Biology and Technology · doi:10.1590/s1516-89132014005000018 · Cited by 52 · see citing works
Patra, J. K., Patra, A. P., Mahapatra, N., Thatoi, H., Das, S. K., Sahu, R. K., & Swain, G. C. (2009) · Malaysian Journal of Microbiology · doi:10.21161/mjm.15409 · Cited by 50 · see citing works
Cyanotherapeutics: An emerging field for future drug discovery
Tiwari, A. K., & Tiwari, B. S. (2020) · Applied Phycology · doi:10.1080/26388081.2020.1744480 · Cited by 49 · see citing works
Guttroff, C., Baykal, A., Wang, H., Popella, P., Kraus, F., Biber, N., Krauss, S., Götz, F., & Plietker, B. J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707069 · Cited by 48 · see citing works
Antibacterial products of marine organisms
Ng, T. B., Cheung, R. C. F., Wong, J. H., Bekhit, A. A., & Bekhit, A. E. A. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6553-x · Cited by 44 · see citing works
Sagar, S., Esau, L. E., Hikmawan, T., Antunes, A., Holtermann, K., Stingl, U., Bajić, V. B., & Kaur, M. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-29 · Cited by 43 · see citing works
Anticancer compounds from cyanobacterium Lyngbya species: a review
Swain, S. S., Padhy, R. N., & Singh, P. K. (2015) · Antonie van Leeuwenhoek · doi:10.1007/s10482-015-0487-2 · Cited by 42 · see citing works
Gkelis, S., Panou, M., Konstantinou, D., Apostolidis, P., Kasampali, A., Papadimitriou, S. A., Kati, D., Lorenzo, G. D., Ioakeim, S., Zervou, S., et al. (2019) · Toxins · doi:10.3390/toxins11080436 · Cited by 40 · see citing works
Current perspectives on the dynamics of antibiotic resistance in different reservoirs
Caniça, M., Manageiro, V., Jones‐Dias, D., Clemente, L., Gomes-Neves, E., Poeta, P. A. C. Q. D., Dias, E. M., & Ferreira, E. (2015) · Research in Microbiology · doi:10.1016/j.resmic.2015.07.009 · Cited by 38 · see citing works
Freitas, S., Martins, R., Costa, M., Leão, P., Vitorino, R., Vasconcelos, V., & Urbatzka, R. (2016) · Marine Drugs · doi:10.3390/md14090158 · Cited by 37 · see citing works
Self-citationGantar, M., Kaczmarsky, L. T., Stanić, D., Miller, A. W., & Richardson, L. L. (2011) · Marine Drugs · doi:10.3390/md9102089 · Cited by 37 · see citing works
Bioprospecting microalgae and cyanobacteria for biopharmaceutical applications
Saeed, M. U., Hussain, N., Shahbaz, A., Hameed, T., Iqbal, H. M. N., & Bilal, M. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100445 · Cited by 38 · see citing works
Unravelling unknown cyanobacteria diversity linked with HCN production
Panou, M., & Gkelis, S. (2021) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2021.107322 · Cited by 37 · see citing works
Pramanik, A., Sundararaman, M., Das, S., Ghosh, U., & Mukherjee, J. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.01017.x · Cited by 35 · see citing works
Biodegradation of nodularin and effects of the toxin on bacterial isolates from the Gulf of Gdańsk
Mazur‐Marzec, H., Toruńska-Sitarz, A., Błońska, M. J., Moskot, M., Pliński, M., Jakóbkiewicz‐Banecka, J., & Węgrzyn, G. (2009) · Water Research · doi:10.1016/j.watres.2009.03.042 · Cited by 35 · see citing works
Bioprospecting Sponge-Associated Marine Cyanobacteria to Produce Bioactive Compounds
Konstantinou, D., Mavrogonatou, E., Zervou, S., Giannogonas, P., & Gkelis, S. (2020) · Toxins · doi:10.3390/toxins12020073 · Cited by 32 · see citing works
Engineering versatile nano-bacteria hybrids for efficient tumor therapy
Wang, W., Yu, W., Li, G., Huang, H., Song, X., Chen, Y., & Chen, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215178 · Cited by 33 · see citing works
Jasser, I., & Callieri, C. (2016) · doi:10.1002/9781119068761.ch3 · Cited by 32 · see citing works
Almeida, J. R., Freitas, M., Cruz, S., Leão, P. N., Vasconcelos, V. M., & Cunha, I. (2015) · Toxins · doi:10.3390/toxins7082739 · Cited by 31 · see citing works
Self-citationCosta, M., Costa, M., Ramos, V., Leão, P. N., Barreiro, A., Vasconcelos, V. M., & Martins, R. F. (2015) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2014.991466 · Cited by 30 · see citing works
Self-citationJaseera, K. V., Kaladharan, P., Vijayan, K. K., Sandhya, S. V., Antony, M. L., & Pradeep, M. A. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1627-7 · Cited by 29 · see citing works
Lopes, V. R., Schmidtke, M., Fernandes, M. H., Martins, R. F., & Vasconcelos, V. M. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.03.003 · Cited by 29 · see citing works
Self-citationSrivastava, A., Tiwari, R., Srivastava, V. K., Singh, T. B., & Asthana, R. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136838 · Cited by 27 · see citing works
Barboza, G. F. D. O., Gorlach‐Lira, K., Sassi, C. F. D. C., & Sassi, R. (2017) · Revista de Biología Tropical · doi:10.15517/rbt.v65i3.29437 · Cited by 21 · see citing works
do Amaral, S. C., Santos, A. V., Schneider, M. P. C., da Silva, J. K. R., & Xavier, L. P. (2020) · Molecules · doi:10.3390/molecules25204744 · Cited by 21 · see citing works
Antitumor and antimicrobial activity of fatty acids from green microalga Coelastrella sp. BGV
Toshkova-Yotova, T., Georgieva, A. K., Iliev, I., Alexandrov, S., Ivanova, A. P., Pilarski, P. S., & Toshkova, R. A. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.04.003 · Cited by 21 · see citing works
Moghaddam, F. D., Hamedi, S., & Dezfulian, M. (2016) · Comparative Clinical Pathology · doi:10.1007/s00580-016-2285-2 · Cited by 20 · see citing works
Bubak, I., Śliwińska‐Wilczewska, S., Głowacka, P., Szczerba, A., & Możdżeń, K. (2020) · Toxins · doi:10.3390/toxins12040259 · Cited by 20 · see citing works
Bioactive Potential of Two Marine Picocyanobacteria Belonging to Cyanobium and Synechococcus Genera
Pagliara, P., Benedetto, G. E. D., Francavilla, M., Barca, A., & Caroppo, C. (2021) · Microorganisms · doi:10.3390/microorganisms9102048 · Cited by 19 · see citing works
Qiao, L., Chang, Z., Li, J., Chen, Z., Yang, L., & Luo, Q. (2019) · Aquaculture Research · doi:10.1111/are.14213 · Cited by 18 · see citing works
Chen, Z., Chang, Z., Wang, J., Liu, Y., Chen, S., & Li, J. (2021) · Aquaculture Research · doi:10.1111/are.15535 · Cited by 18 · see citing works
Anticancer activity of Cyanothece sp. strain extracts from Egypt: First record
Semary, N. A. H. E., & Fouda, M. S. (2015) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2015.09.004 · Cited by 18 · see citing works
Synergistic effect of elevated temperature, pCO2 and nutrients on marine biofilm
Baragi, L. V., & Anil, A. C. (2016) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2016.02.049 · Cited by 18 · see citing works
Microalgae Biorefineries for Energy and Coproduct Production
Gorry, P., Sánchez, L., & Morales, M. (2018) · Green energy and technology · doi:10.1007/978-3-319-69093-3_5 · Cited by 18 · see citing works
Anticancer potential and cytotoxic effect of some freshwater cyanobacteria
Karan, T., & Aydın, A. O. (2019) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v17i11.11 · Cited by 17 · see citing works
Barreiro, A., Śliwińska‐Wilczewska, S., Klin, M., Konarzewska, Z., & Vasconcelos, V. M. (2019) · Hydrobiologia · doi:10.1007/s10750-019-3933-8 · Cited by 17 · see citing works
Self-citationAntiviral effect of edaphic cyanophytes on rabies and herpes-1 viruses
Mansour, H. A., Shoman, S. A. H., & Kdodier, M. (2011) · Acta Biologica Hungarica · doi:10.1556/abiol.62.2011.2.9 · Cited by 15 · see citing works
Regueiras, A., Pereira, S., Costa, M., & Vasconcelos, V. M. (2018) · Toxins · doi:10.3390/toxins10070297 · Cited by 16 · see citing works
Self-citationCaires, T. A., da Silva, A. M. S., Vasconcelos, V. M., Affe, H. M. D. J., Neta, L. C. D. S., Boness, H. V. M., Sant’Anna, C. L., & Nunes, J. M. C. (2018) · Algal Research · doi:10.1016/j.algal.2018.10.001 · Cited by 17 · see citing works
Self-citationCyanobacterial interactions and symbiosis
Manoharan, D., Ramachandran, T., Sivakumar, N., & Rajaram, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13231-5.00004-0 · Cited by 15 · see citing works
Bahman, M., Jalili, H., Etesam, M., & Amrane, A. (2022) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2022.102820 · Cited by 15 · see citing works
Gacheva, G. V., Gigova, L. G., Ivanova, N., Iliev, I., Toshkova, R. A., Gardeva, E. G., Kussovski, V. K., & Najdenski, H. M. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9852-y · Cited by 15 · see citing works
Synechocystis salina: potential bioactivity and combined extraction of added-value metabolites
Assunção, J., Amaro, H. M., Lopes, G., Tavares, T. G., Malcata, F. X., & Guedes, A. C. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02558-1 · Cited by 14 · see citing works
Insight to biotechnological utility of phycochemicals from cyanobacterium Anabaena sp.: An overview
Mandhata, C. P., Bishoyi, A. K., Sahoo, C. R., Maharana, S., & Padhy, R. N. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105594 · Cited by 13 · see citing works
Razack, S. A., Surendhiran, D., Kozani, P. S., Kozani, P. S., Hamidi, M., Cabrera‐Barjas, G., & Delattre, C. (2021) · Algal Research · doi:10.1016/j.algal.2021.102556 · Cited by 14 · see citing works
Ouhsassi, M., Khay, E. O., Bouyahya, A., Ouahrani, A. E., Harsal, A. E., & Abrini, J. (2020) · Applied Water Science · doi:10.1007/s13201-020-01270-8 · Cited by 13 · see citing works
Suphan, S., Limrujiwat, K., Kula, K., Maneeruttanarungroj, C., Raksajit, W., & Khetkorn, W. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102826 · Cited by 11 · see citing works
Xie, R., Chen, F., Ma, Y., Hu, W., Zheng, Q., Cao, J., & Wu, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249632 · Cited by 11 · see citing works
Wang, F., Zhang, H., Liang, J., Feng, D., Tang, Q., Yu, K., & Shang, Z. (2016) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2016.09.141 · Cited by 11 · see citing works
Dash, S., Pradhan, S., Sahoo, B., Parida, S., & Rath, B. (2023) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-023-00186-z · Cited by 11 · see citing works
Antimicrobial Activity of Marine Microalgae
Ognistaya, A. V., Маркина, Ж. В., & Orlova, T. Y. (2022) · Russian Journal of Marine Biology · doi:10.1134/s1063074022040071 · Cited by 10 · see citing works
Kanellopoulos, C., Lamprinou, V., Politi, A., Voudouris, P. C., Iliopoulos, I., Kokkaliari, M., Moforis, L., & Economou‐Amilli, A. (2022) · Minerals · doi:10.3390/min12111408 · Cited by 10 · see citing works
Synthetic approaches toward the marine alkaloid prenostodione
Badenock, J. C., Jordan, J. A., & Gribble, G. W. (2013) · Tetrahedron Letters · doi:10.1016/j.tetlet.2013.02.116 · Cited by 10 · see citing works
Fatima, N., Ahmad, I. Z., & Chaudhry, H. (2015) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2015.10.014 · Cited by 10 · see citing works
Cyanobacteria: a potential source of anticancer drugs
Mehta, A., Soni, V. K., Shukla, D., & Vishvakarma, N. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819311-2.00024-3 · Cited by 9 · see citing works
A Novel Application of Laser in Biocontrol of Plant Pathogenic Bacteria
Semary, N. A. H. E., Naim, H. M. A., & Aldayel, M. F. (2022) · Applied Sciences · doi:10.3390/app12104933 · Cited by 9 · see citing works
Marine Cyanobacteria Compounds with Anticancer Properties: Implication of Apoptosis
Martins, M. D. R., & Costa, M. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_29 · Cited by 9 · see citing works
Algal engineering for bioremediation, bioenergy production, and biomedical applications
Ahmad, A., BANAT, F. A., & Taher, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90476-6.00015-7 · Cited by 8 · see citing works
Wijesekara, W. A. M. A., & Manage, P. M. (2017) · Journal of Tropical Forestry and Environment · doi:10.31357/jtfe.v7i2.3310 · Cited by 8 · see citing works
Azmy, L., Ibraheem, I., Alsalamah, S. A., Alghonaim, M. I., Zayed, A., El‐Aleam, R. H. A., Mohamad, S. A., Abdelmohsen, U. R., & Elsayed, K. N. M. (2024) · Biology · doi:10.3390/biology13080581 · Cited by 7 · see citing works
Guttroff, C., Baykal, A., Wang, H., Popella, P., Kraus, F., Biber, N., Krauss, S., Götz, F., & Plietker, B. J. (2017) · Angewandte Chemie · doi:10.1002/ange.201707069 · Cited by 7 · see citing works
Landscape of natural product diversity in land-plants as source for anticancer molecules
Srivastava, A., & Raghuwanshi, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821710-8.00010-2 · Cited by 6 · see citing works
Algae biotechnology for nutritional and pharmaceutical applications
Narayanan, M., Kandasamy, S., He, Z., Hemaiswarya, S., Raja, R., & Carvalho, I. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89837-9.00015-2 · Cited by 6 · see citing works
Heisnam, R., Keithellakpam, O. S., Kshetrimayum, V., Mukherjee, P. K., & Sharma, N. (2022) · Algal Research · doi:10.1016/j.algal.2022.102852 · Cited by 6 · see citing works
A novel antioxidant and antimicrobial compound produced by Bacillus firmicutes
Ahmed, Y. M., & Jambi, I. J. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.33-17-3300 · Cited by 6 · see citing works
Wietz, M., Månsson, M., Vynne, N. G., & Gram, L. (2013) · Wiley eBooks · doi:10.1002/9783527665259.ch08 · Cited by 6 · see citing works
DASH, S., Parida, S., Sahoo, B., & Rath, B. (2022) · Research Square · doi:10.21203/rs.3.rs-1272821/v1 · Cited by 6 · see citing works
Shawer, E. E., El-Gamal, A., Sabae, S., & Elsaied, H. E. (2022) · Egyptian journal of phycology · doi:10.21608/egyjs.2022.143340.1013 · Cited by 5 · see citing works
Bioactive molecules from microalgae and constraints in commercialization
Singh, U., Laxmi, L., Singh, A. K., & Asthana, R. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820655-3.00007-0 · Cited by 5 · see citing works
Natural Compounds from Algae and Spirulina platensis & its Antimicrobial Activity
Kumar, V., SaranTirumalai, P., Singh, A., Bhatnagar, A. K., & Shrivastava, J. N. (2013) · Indo Global Journal of Pharmaceutical Sciences · doi:10.35652/igjps.2013.26 · Cited by 5 · see citing works
Teneva, I. I., Batsalova, T., Moten, D., Petkova, Z. Y., Teneva, O. T., Angelova‐Romova, M., Antova, G., & Dzhambazov, B. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115086 · Cited by 4 · see citing works
Heisnam, R. (2024) · American Journal of Cancer Research · doi:10.62347/jtnq4812 · Cited by 4 · see citing works
Screening of Lipid-Reducing Activity and Cytotoxicity of the Exometabolome from Cyanobacteria
Luz, R., Cordeiro, R., Gonçalves, V., Vasconcelos, V. M., & Urbatzka, R. (2024) · Marine Drugs · doi:10.3390/md22090412 · Cited by 4 · see citing works
Self-citationAnticancer Drug Development from Cyanobacteria
Mandal, S., & Rath, J. (2014) · SpringerBriefs in pharmaceutical science & drug development · doi:10.1007/978-3-319-12009-6_4 · Cited by 4 · see citing works
Mukherjee, A. G., & Kamla Nehru Mahavidyalaya, N.-2. (2020) · International Journal of Engineering Research and · doi:10.17577/ijertv9is070578 · Cited by 4 · see citing works
- Authors
- Martins, R., Ramos, M., Herfindal, L., Sousa, J., Skærven, K., & Vasconcelos, V.
- Affiliations
- Universidade do Porto (PT)
- University of Bergen (NO)
- Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
- Corresponding author
- Vasconcelos, Vitor
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2008-01-22
- Volume
- 6
- Issue
- 1
- Pages
- 1-11
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W4297835311
- Cited by
- 117
- References
- 26
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine cyanobacteria, Synechocystis, Synechococcus, antimicrobial activity, cytotoxicity, apoptosis, HL-60 cells, rat hepatocytes, Cellulomonas uda, Candida albicans, Gram-positive bacteria, organic solvent extracts, aqueous extract, natural products
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