Cited by 331Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsMicrobial Metabolism and Applications

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Antitumor Compounds from Marine Actinomycetes

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Olano, Carlos, Méndez, Carmen, Salas, José A.·2009·Marine Drugs

DOI 10.3390/md7020210PMC PMC2707044

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Abstract

Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.

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Authors: Olano, C., Méndez, C., & Salas, J. A.
Affiliations: Universidad de Oviedo (ES)
Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain
Corresponding author: Salas, José A.
ORCID: Olano, Carlos
Salas, José A.
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2009-06-11
Volume: 7
Issue: 2
Pages: 210-248
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md7020210
PMC: PMC2707044
OpenAlex: W1985089556
Cited by: 330
References: 191
Citations by year: 2026: 15 · 2025: 10 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 10 · 2016: 21 · 2015: 27 · 2014: 21 · 2013: 32 · 2012: 24
FWCI: 2.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords: anticancer agents, marine actinomycetes, natural products, anthracyclines, enediynes, indolocarbazole, macrolides, nonribosomal peptides, topoisomerase inhibition, apoptosis, angiogenesis inhibition, cancer chemotherapy
MeSH terms: Animals, Antineoplastic Agents, Carbazoles, Glycosides, Humans, Marine Biology, Peptides, Terpenes, Actinobacteria

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