The DOI matches its Crossref record; 187 of the 191 references it cites were found in a registry or an index.
Antitumor Compounds from Marine Actinomycetes
Open accessAbstract
Chemotherapy is one of the main treatments used to combat cancer. A great number of antitumor compounds are natural products or their derivatives, mainly produced by microorganisms. In particular, actinomycetes are the producers of a large number of natural products with different biological activities, including antitumor properties. These antitumor compounds belong to several structural classes such as anthracyclines, enediynes, indolocarbazoles, isoprenoides, macrolides, non-ribosomal peptides and others, and they exert antitumor activity by inducing apoptosis through DNA cleavage mediated by topoisomerase I or II inhibition, mitochondria permeabilization, inhibition of key enzymes involved in signal transduction like proteases, or cellular metabolism and in some cases by inhibiting tumor-induced angiogenesis. Marine organisms have attracted special attention in the last years for their ability to produce interesting pharmacological lead compounds.
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“Of these actinomycete-derived compounds, 75% were derived from Streptomyce whereas 25% were derived from rare actinomycetes [125,126].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [125]
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“Actinomycete-isolated secondary metabolites account for ca. 45% (~10,000 compounds) of the total known anti-microbial metabolites.”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [125]
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Citations
Cites
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4 of the 191 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
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Marine Sponge-Associated Microbes
Kim, S., Dewapriya, P., & Li, Y.-X. (2012) · CRC Press eBooks · doi:10.1201/b13868-20
Pinto, A. C. D. G. R. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.59.2022.tde-05092022-074116
Coastal Sediments of La Paz Bay BCS: Bacteria Reserve with Biotechnological Potential
Montano-Lopez, F., González‐Acosta, B., Cardona-Félix, C. S., Muñoz‐Ochoa, M., & Sánchez-Burgos, J. A. (2023) · Springer eBooks · doi:10.1007/978-981-19-4336-2_11
Marhamati, Z., Marhamatizadeh, M. H., & Mohebbi, G. H. (2021) · Iranian South Medical Journal · doi:10.52547/ismj.24.1.27
Exploring the Bioactivity of Soil Streptomyces sp. BACSAS14: An In Vitro and In Silico Approach
Agarwal, S., Vivekanandan, S., Mooventhan, H., Vaithilingam, M., & Chandrasekaran, S. D. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230502111736
Shoukath, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4586911
Advanced approaches in cancer therapy via administration of polymer-based particles
Xiao, X., & Li, W. (2023) · Advances in chemical engineering · doi:10.1016/bs.ache.2023.09.001
Saengkhae, C. (2018) · Chulalongkorn Medical Journal · doi:10.58837/chula.cmj.62.2.2
Olukunle, O. F., Abe, A. S., Fajoyegbe, E. S., Akinde, S. B., Kolawole, A. O., & Falese, B. A. (2024) · European journal of applied sciences · doi:10.14738/aivp.123.17066
Akhter, S., Manzoor, M. M., Mir, S. A., Khaliq, T., Sultan, P., & Hassan, Q. P. (2024) · Medicinal Plant Biology · doi:10.48130/mpb-0024-0021
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Tackling MDR bacterial pathogens through marine microbial prospecting
Jeyaraj, J. W., Naveena, K., Ponmanickam, P., Deepalakshmi, U., & Sivakumar, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26771-0.00020-5
Bioactive Compounds from Streptomycetes for Applications in Diverse Fields
Garima, Kaur, J., Thakur, R., & Kaur, S. (2026) · Springer eBooks · doi:10.1007/978-981-95-5803-2_3
Kollerov, V., Pavshintsev, V. V., Kazantsev, A. V., Шутов, А. А., Vatlin, A. A., Mitkin, N. A., Fadeeva, O. V., Lovat, M. L., Morgun, E. O., & Donova, M. V. (2026) · Biomolecules · doi:10.3390/biom16020196
Zhang, Y., Zhang, T., Gao, J., Han, D., Li, X., Zhang, Y., Tu, F., Yi, Y., & Lu, X. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108695
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Hamed, A. A., Awady, M. E. E., Yassin, M. H., Elnagar, D. M. M., & Hassan, M. G. (2026) · BMC Microbiology · doi:10.1186/s12866-026-04962-4
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Gharbi, M., & Abbassi, M. S. (2026) · Letters in Applied Microbiology · doi:10.1093/lambio/ovag050
Unique therapeutic potential of bacterial metabolites for cancer chemotherapy
DEBNATH, A., Imamura, D., Kawase, T., MAITY, A., & Koley, H. (2026) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2026.06.001
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Bioactive Compounds from Marine Actinobacteria
Dubey, D., Rout, D., Mehta, A. R., Mandal, S., Jain, R., Kumari, P., Suresh, K. N., & Devi, C. S. (2026) · Springer eBooks · doi:10.1007/978-981-95-9849-6_5
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BindingDB Entry 50046048: Natural Product Primary Sulfonamides and Primary Sulfamates.
BindingDB (2016) · UC San Diego · doi:10.7270/q2cf9rv7
Metadata
- Authors
- Olano, C., Méndez, C., & Salas, J. A.
- Affiliations
- Universidad de Oviedo (ES)
- Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain
- Corresponding author
- Salas, José A.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2009-06-11
- Volume
- 7
- Issue
- 2
- Pages
- 210-248
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC2707044
- OpenAlex
- W1985089556
- Cited by
- 330
- References
- 191
- Citations by year
- 2026: 15 · 2025: 10 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 19 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 10 · 2016: 21 · 2015: 27 · 2014: 21 · 2013: 32 · 2012: 24
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- anticancer agents, marine actinomycetes, natural products, anthracyclines, enediynes, indolocarbazole, macrolides, nonribosomal peptides, topoisomerase inhibition, apoptosis, angiogenesis inhibition, cancer chemotherapy
- MeSH terms
- Animals, Antineoplastic Agents, Carbazoles, Glycosides, Humans, Marine Biology, Peptides, Terpenes, Actinobacteria
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