Antitumor Compounds from Marine Actinomycetes

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Metabolites from symbiotic bacteria

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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

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Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

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Telomerase and cancer

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Renaissance in antibacterial discovery from actinomycetes

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Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

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Marine actinobacteria: new opportunities for natural product search and discovery

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Actinomycetes for marine drug discovery isolated from mangrove soils and plants in China

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Phylogenetic Diversity of Gram-Positive Bacteria Cultured from Marine Sediments

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Actinomycetes as agents of biodegradation in the environment — a review

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Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora

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Metabolites from symbiotic bacteriaThis review is dedicated to Professor Axel Zeeck on the occasion of his 65th birthday.

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Abyssomicins, Inhibitors of the para-Aminobenzoic Acid Pathway Produced by the Marine Verrucosispora Strain AB-18-032

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Marinomycins A−D, Antitumor-Antibiotics of a New Structure Class from a Marine Actinomycete of the Recently Discovered Genus “ Marinispora ”

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Diversity of actinomycetes isolated from Challenger Deep sediment (10,898 m) from the Mariana Trench

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Marine actinomycetes as a source of novel secondary metabolites

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Identification of Ras farnesyltransferase inhibitors by microbial screening.

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

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Taxonomy, Fermentation, Isolation and Biological Activities.

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Marine actinobacteria: perspectives, challenges, future directions

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The prodigiosins, proapoptotic drugs with anticancer properties

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Panning for chemical gold: marine bacteria as a source of new therapeutics

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Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities.

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NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

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Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity

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The Ammosamides: Structures of Cell Cycle Modulators from a Marine‐Derived Streptomyces Species

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Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

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Deciphering the Biosynthesis Pathway of the Antitumor Thiocoraline from a Marine Actinomycete and Its Expression in Two Streptomyces Species

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Diversity and biogeography of marine actinobacteria

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Optimization and production of novel antimicrobial agents from sponge associated marine actinomycetes Nocardiopsis dassonvillei MAD08

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New Cytotoxic Salinosporamides from the Marine Actinomycete Salinispora tropica

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Cyanosporasides A and B, Chloro- and Cyano-cyclopenta[ a ]indene Glycosides from the Marine Actinomycete “ Salinispora pacifica ”

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Microbial technologies for the discovery of novel bioactive metabolites

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Marine pharmacology in 2003–4: Marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action

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Antibiotic Terpenoid Chloro-Dihydroquinones from a New Marine Actinomycete

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A Gene Cluster from a Marine Streptomyces Encoding the Biosynthesis of the Aromatic Spiroketal Polyketide Griseorhodin A

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Proximicin A, B and C, Novel Aminofuran Antibiotic and Anticancer Compounds Isolated from Marine Strains of the Actinomycete Verrucosispora†

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Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry

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Inhibition of Human Telomerase by Rubromycins: Implication of Spiroketal System of the Compounds as an Active Moiety

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Lynamicins A−E, Chlorinated Bisindole Pyrrole Antibiotics from a Novel Marine Actinomycete

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Sporolides A and B: Structurally Unprecedented Halogenated Macrolides from the Marine Actinomycete Salinispora t ropica

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Chandrananimycins A-C: Production of Novel Anticancer Antibiotics from a Marine Actinomadura sp. Isolate M048 by Variation of Medium Composition and Growth Conditions

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Biosynthetic Studies of Daunorubicin and Tetracenomycin C

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Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

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Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251

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Thiocoraline, a Novel Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora. II. Physico-chemical Properties and Structure Determination.

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Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces nodosus

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Cloning of the Staurosporine Biosynthetic Gene Cluster from Streptomyces sp. TP-A0274 and Its Heterologous Expression in Streptomyces lividans.

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Estimating and comparing the diversity of marine actinobacteria

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Recognition and degradation of chitin by streptomycetes

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Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.

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Piperazimycins: Cytotoxic Hexadepsipeptides from a Marine-Derived Bacterium of the Genus Streptomyces

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Deciphering the late steps in the biosynthesis of the anti‐tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

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Lucentamycins A−D, Cytotoxic Peptides from the Marine-Derived Actinomycete Nocardiopsis lucentensis

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Chinikomycins A and B: Isolation, Structure Elucidation, and Biological Activity of Novel Antibiotics from a Marine Streptomyces sp. Isolate M045,1

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Arenamides A−C, Cytotoxic NFκB Inhibitors from the Marine Actinomycete Salinispora arenicola

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Marineosins A and B, Cytotoxic Spiroaminals from a Marine-Derived Actinomycete

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Saliniketals A and B, Bicyclic Polyketides from the Marine Actinomycete Salinispora arenicola

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Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait, China

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Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

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Studies on marine microorganisms. IV. A new antibiotic SS-228 Y produced by Chainia isolated from shallow sea mud.

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Marinone and debromomarinone: Antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium

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Aureoverticillactam, a Novel 22-Atom Macrocyclic Lactam from the Marine Actinomycete Streptomyces aureoverticillatus

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Himalomycin A and B: Isolation and Structure Elucidation of New Fridamycin Type Antibiotics from a Marine Streptomyces Isolate

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Host-microbe interaction: bacteria

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Mode of action of thiocoraline, a natural marine compound with anti-tumour activity

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Arenicolides A−C, 26-Membered Ring Macrolides from the Marine Actinomycete Salinispora arenicola

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Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)

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Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies

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Actinobacterial diversity from marine sediments collected in Mexico

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NF-κB as a target for cancer therapy

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Salinipyrones and Pacificanones, Mixed-Precursor Polyketides from the Marine Actinomycete Salinispora pacifica

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The manumycin-group metabolites

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Biosynthesis of the Antitumor Agent Chartreusin Involves the Oxidative Rearrangement of an Anthracyclic Polyketide

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Proximicins A, B, and C—Antitumor Furan Analogues of Netropsin from the Marine Actinomycete Verrucosispora Induce Upregulation of p53 and the Cyclin Kinase Inhibitor p21

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