The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Vitamin D Deficiency: Consequence or Cause of Obesity?
Open accessAbstract
Obesity is defined as an excess amount of body fat and represents a significant health problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well-documented finding, most probably due to volumetric dilution into the greater volumes of fat, serum, liver, and muscle, even though other mechanisms could not completely be excluded, as they may contribute concurrently. Low VD could not yet be excluded as a cause of obesity, due to its still incompletely explored effects through VD receptors found in adipose tissue (AT). VD deficiency in obese people does not seem to have consequences for bone tissue, but may affect other organs, even though studies have shown inconsistent results and VD supplementation has not yet been clearly shown to benefit the dysmetabolic state. Hence, more studies are needed to determine the actual role of VD deficiency in development of those disorders. Thus, targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. However, VD supplementation remains a treatment option in individuals with residual VD deficiency after weight loss.
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Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Lips, P. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.016 · Cited by 1,173
Pittas, A. G., Harris, S. S., Stark, P. C., & Dawson-Hughes, B. (2007) · Diabetes Care · doi:10.2337/dc06-1994 · Cited by 643
von Hurst, P. R., Stonehouse, W., & Coad, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992017 · Cited by 624
Effects of weight loss on serum vitamin D in postmenopausal women
Mason, C., Xiao, L., Imayama, I., Duggan, C. R., Bain, C., Foster-Schubert, K. E., Kong, A., Campbell, K. L., Wang, C.-Y., Neuhouser, M. L., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.015552 · Cited by 116
Cited by
Consensus statement on vitamin D status assessment and supplementation: Whys, whens, and hows
Giustina, A., Bilezikian, J. P., Adler, R. A., Banfi, G., Bikle, D. D., Binkley, N. C., Bollerslev, J., Bouillon, R., Brandi, M. L., Casanueva, F. F., et al. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae009 · Cited by 392
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89
Pellegrini, M., Rahimi, F., Boschetti, S., Devecchi, A., De Francesco, A., Mancino, M. V., Toppino, M., Morino, M., Fanni, G., Ponzo, V., et al. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01439-7 · Cited by 50
Metadata
- Authors
- Vranić, L., Mikolašević, I., & Milić, S.
- Venue
- Medicina
- Publisher
- MDPI AG
- Published
- 2019-08-28
- Volume
- 55
- Issue
- 9
- Pages
- 541
- ISSN
- 1010-660X (ISSN-L)
- 1648-9144
- OpenAlex
- W2955846833
- Cited by
- 321
- References
- 6
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- gold
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