The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution?
Open accessAbstract
Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility. Although a number of positive findings have emerged from human clinical trials, there remain many conflicting results, which may partially be attributed to the dosing protocols used. A number of theoretical solutions have been developed to improve the bioavailability of resveratrol, including consumption with various foods, micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. While laboratory models indicate these approaches all have potential to improve bioavailability of resveratrol and optimize its clinical utility, there is surprisingly very little data regarding the bioavailability of resveratrol in humans. If bioavailability is indeed a limitation in the clinical utility of resveratrol, there is a need to further explore methods to optimize bioavailability in humans. This review summarizes the current bioavailability data, focusing on data from humans, and provides suggested directions for future research in this realm.
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Cites
Resveratrol improves health and survival of mice on a high-calorie diet
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“Alternatively, the absorption of native quercetin is poor, and may not reach the liver in a concentration that will inhibit SULT in vivo [66].”
BackgroundSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
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BackgroundErroneous analyses of interactions in neuroscience: A problem of significance
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Resveratrol and health—A comprehensive review of human clinical trials
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Self-citationHigh-Dose Resveratrol Supplementation in Obese Men
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Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
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Cited by
Melanoma Chemoprevention: Current Status and Future Prospects
Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., & Ahmad, N. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12749 · Cited by 51
Posey, K. L. (2024) · Biomolecules · doi:10.3390/biom14020154 · Cited by 20
Metadata
- Authors
- Smoliga, J., & Blanchard, O.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-10-24
- Volume
- 19
- Issue
- 11
- Pages
- 17154-17172
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2004171945
- Cited by
- 229
- References
- 12
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Smoliga, J., & Blanchard, O. (2014). Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution? Molecules. https://doi.org/10.3390/molecules191117154
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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