The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity
Open accessAbstract
Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades, several studies dealt with the potential effects of natural products as new safe and effective tools for body weight control. Saponins are naturally-occurring surface-active glycosides, mainly produced by plants, whose structure consists of a sugar moiety linked to a hydrophobic aglycone (a steroid or a triterpene). Many pharmacological properties have been reported for these compounds, such as anti-inflammatory, immunostimulant, hypocholesterolemic, hypoglycemic, antifungal and cytotoxic activities. The aim of this review is to provide an overview of recent studies about the anti-obesity therapeutic potential of saponins isolated from medicinal plants. Results on the in vitro and in vivo activity of this class of phytochemicals are here presented and discussed. The most interesting findings about their possible mechanism of action and their potential health benefits in the treatment of obesity are reported, as well.
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Cites
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Cited by
Marrelli, M. (2021) · Plants · doi:10.3390/plants10071355 · Cited by 91
Self-citationAnti-Adipogenic Activity of Rhaponticum carthamoides and Its Secondary Metabolites
Todorova, V., Savova, M. S., Ivanova, S., Ivanov, K., & Georgiev, M. I. (2023) · Nutrients · doi:10.3390/nu15133061 · Cited by 12
Kaur, S., Ghosh, A., J, S., Kaur, G., Singh, G., Pandey, P., Kumar, A., Seem, K., Bhardwaj, R., & Riar, A. (2025) · Food Chemistry Advances · doi:10.1016/j.focha.2025.101066 · Cited by 7
Metadata
- Authors
- Marrelli, M., Conforti, F., Araniti, F., & Statti, G.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-10-20
- Volume
- 21
- Issue
- 10
- Pages
- 1404
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2532850922
- Cited by
- 283
- References
- 87
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Marrelli, M., Conforti, F., Araniti, F., & Statti, G. (2016). Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules. https://doi.org/10.3390/molecules21101404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
